Characteristics of methicillin-resistant Staphylococcus aureus in patients on admission to a teaching hospital in Rio de Janeiro, Brazil

Cavalcante, Fátima Gonçalves; Pinheiro, Marcos Vinicius; Ferreira, Dennis Carvalho; Alvarenga, Celina Vieira da Cunha Guedes; Guimarães, Ana Carolina Fonseca; Nouér, Simone Aranha; Santos, Kátia Regina Netto dos

doi:10.1016/j.ajic.2017.06.003

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…Moreover, the prevalence of MRSA in our study was even higher when compared to the ones found in non‐EB populations in Brazil 24–26 and also worldwide 27–29 . We believe these findings are alarming once MRSA is more associated with life‐threatening complications and poorer outcomes than other strains 24,27,29–34 . In addition, this reinforces the possibility that the wide and indiscriminate use of antibiotics by EB patients might be the origin of these increased rates of resistance, which can contribute to difficulties in the management of complications.…”

Section: Discussionsupporting

confidence: 50%

“…aureus than patients with atopic dermatitis but presented the highest colonization rates by MRSA 22 . Moreover, the prevalence of MRSA in our study was even higher when compared to the ones found in non‐EB populations in Brazil 24–26 and also worldwide 27–29 . We believe these findings are alarming once MRSA is more associated with life‐threatening complications and poorer outcomes than other strains 24,27,29–34 .…”

Section: Discussioncontrasting

confidence: 47%

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Prevalence and antimicrobial resistance profile of Staphylococcus aureus in inherited epidermolysis bullosa: a cross‐sectional multicenter study in Brazil

et al. 2021

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Background Infection is an important complication of epidermolysis bullosa (EB), and Staphylococcus aureus has been pointed out as the most common pathogen among this population. The objective of this study was to investigate the prevalence and antimicrobial resistance profile of S. aureus colonizing EB patients in Brazil. Methods This cross‐sectional multicenter study was conducted between December 2015 and December 2017. We included a total of 89 individuals with EB from medical centers across Brazil. Data were obtained through clinical and bacteriological investigation. S. aureus were identified by biochemical tests. The nuc and mecA genes were confirmed by PCR assay. Antimicrobial susceptibility was investigated by disk diffusion method. Results The overall prevalence of S. aureus was 51.7% (46/89). Methicillin‐resistant S. aureus (MRSA) was detected in 24.7% (19/77) of all S. aureus isolates, colonizing 15.7% (14/89) of all patients. Community‐associated (CA)‐MRSA strains were resistant against sulfamethoxazole/trimethoprim and levofloxacin (P < 0.05%). S. aureus colonization of the nares and belly button represented a 3.4 times higher risk of simultaneous skin lesion colonization (P < 0.05%). Conclusions The high frequency of MRSA colonizing patients with EB is alarming considering its association with life‐threatening complications and poorer outcomes. EB patients are at increased risk of colonization and infection by Staphylococcus aureus and CA‐MRSA. Getting to know S. aureus carriage sites and its antimicrobial susceptibility profile is key when planning new individualized and more effective prophylactic and therapeutic measures.

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Section: Discussionsupporting

confidence: 50%

Section: Discussioncontrasting

confidence: 47%

Prevalence and antimicrobial resistance profile of Staphylococcus aureus in inherited epidermolysis bullosa: a cross‐sectional multicenter study in Brazil

et al. 2021

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“…13 There are limited data on prevalence, molecular epidemiology and risk factors for MRSA colonization upon admission, discriminated by genotypes for both CA-MRSA and HA-MRSA (CA-MRSA G and HA-MRSA G , respectively), in Latin America-(LA). 25 On the other hand, the relationship between HAHO or hospital-acquired infections by CA-MRSA G and the carriage statu upon admission remains unclear.…”

Section: Introductionmentioning

confidence: 99%

MRSA dynamic circulation between the community and the hospital setting: New insights from a cohort study

Barcudi

Sosa

Lamberghini

et al. 2020

Journal of Infection

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“…In the 2010s, MRSA remained being increasingly reported in Brazil, as shown in Figure 4 . The most common clones in the hospital environment continued to be those carrying the SCC mec types II, III, and IV [ 14 , 65 , 73 , 102 , 103 ]. However, SCC mec type II, in contrast to the last decade, was reported as one of the most prevalent clone [ 103 – 109 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most common clones in the hospital environment continued to be those carrying the SCC mec types II, III, and IV [ 14 , 65 , 73 , 102 , 103 ]. However, SCC mec type II, in contrast to the last decade, was reported as one of the most prevalent clone [ 103 – 109 ]. Relevantly, the New York/Japan clone, which carries SCC mec type II, was shown to become resistant to daptomycin, tigecycline, and vancomycin [ 67 , 110 ].…”

Section: Introductionmentioning

confidence: 99%

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

Andrade

Luiz

Souza

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Since the emergence of MRSA in the 1960s, a gradual increase in infections by resistant bacteria has been observed. Clinical manifestations may vary from brand to critical condition due to host risk factors, as well as pathogen virulence and resistance. The high adaptability and pathogenic profile of MRSA clones contributed to its spread in hospital and community settings. In Brazil, the first MRSA isolates were reported in the late 1980s, and since then different genetic profiles, such as the Brazilian epidemic clone (BEC) and other clones considered a pandemic, became endemic in the Brazilian population. Additionally, Brazil’s MRSA clones were shown to be able to transfer genes involved in multidrug resistance and enhanced pathogenic properties. These events contributed to the rise of highly resistant and pathogenic MRSA. In this review, we present the main events which compose the history of MRSA in Brazil, including numbers and locations of isolation, as well as types of staphylococcal cassette chromosome mec (SCCmec) found in the Brazilian territory.

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Characteristics of methicillin-resistant Staphylococcus aureus in patients on admission to a teaching hospital in Rio de Janeiro, Brazil

Cited by 10 publications

References 25 publications

Prevalence and antimicrobial resistance profile of Staphylococcus aureus in inherited epidermolysis bullosa: a cross‐sectional multicenter study in Brazil

Prevalence and antimicrobial resistance profile of Staphylococcus aureus in inherited epidermolysis bullosa: a cross‐sectional multicenter study in Brazil

MRSA dynamic circulation between the community and the hospital setting: New insights from a cohort study

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

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