Characteristics of metastasis and survival between male and female breast cancer with different molecular subtypes: A population‐based observational study

Fang, Wentong; Huang, Yue; Han, Xu; Peng, Jinghui; Zheng, Mingzhe

doi:10.1002/cam4.4469

Cited by 9 publications

(7 citation statements)

References 51 publications

(83 reference statements)

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“…Their research may help doctors accurately predict the prognoses of patients and develop precise medical treatment plans, further improving prognoses. Studies applying statistical analysis methods to BC found that men with different molecular subtypes with MBCB had very different onset patterns and prognoses [92] . This information facilitates the development of precise treatment plans for patients of all molecular subtypes.…”

Section: Discussionmentioning

confidence: 99%

How has the field of metastatic breast cancer in bones evolved over the past 22 years?

Chen¹,

Guo²,

He³

et al. 2023

Journal of Bone Oncology

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Section: Discussionmentioning

confidence: 99%

How has the field of metastatic breast cancer in bones evolved over the past 22 years?

Chen¹,

Guo²,

He³

et al. 2023

Journal of Bone Oncology

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“…An observational retrospective study of 53 MBCs by Herrero et al observed that 77% of the patients were former smokers and 17% had history of alcoholism [4]. A SEER-based analysis of 1704 MBCs and 225,417 FBCs from 2010 to 2016 by Fang et al observed that MBCs had older age and a higher rate of Black race [8].…”

Section: Methodsmentioning

confidence: 99%

“…MBCs also had higher incidence of distant metastases at the time of diagnosis (5.93% vs. 4.12% in FBCs), with bone being the most common metastatic site (85.29%). Hormone-/HER2-had the highest distant metastatic rate in MBC (21.26%) [8]. Elimimian et al, in their analysis of MBCs and FBCs in National Cancer Database (NCDB), observed that male patients presented with later clinical staging and exhibit worse disease grade and worse comorbidity scores.…”

mentioning

confidence: 99%

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Male Breast Cancer: An Updated Review of Patient Characteristics, Genetics, and Outcome

Khare,

Huda,

Misra

et al. 2024

International Journal of Breast Cancer

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Male breast cancer (MBC) is a rare entity, underrepresented in population studies and clinical trials, resulting in management of MBC to be informed by current research on female breast cancer (FBC). A literature review was conducted by accessing relevant articles on 2 databases, by searching keywords “male breast cancer”. A total of 29 articles from year 2011 to 2022 were selected for this review. The authors found that male breast cancer generally occurs later in life with higher stage, higher grade, and more estrogen receptor (ER) positive tumours. Most of the studies noted the mean age for MBCs at the time of presentation as >60 years. Risk factors for male breast cancer include family history, obesity, lower physical activity, and syndromes like the Klinefelter syndrome. Positive family history is much higher in MBC compared to FBC (30.9 vs. 18.4%). BRCA 2 cancers constitute a higher proportion compared to FBCs. A lot of genetic mutations have been observed. Some show promise to assess disease-specific survival and proliferative rate like TWIST1 and RUNX3, among others. MBCs usually present with a palpable lump in central region, with a bigger size and chance of nodal involvement and metastasis compared to FBCs. They are mostly infiltrating ductal type and hormone receptor positive, with worse histological grade. Treatment usually follows the same principles as FBCs (systemic therapy, surgical excision, and radiotherapy), with poorer prognosis to same treatment approach, possibly owing to its advanced stage at presentation. This is a rare entity which requires further research to ascertain need for different management approach than FBCs.

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“…Chen et al [ 10 ] investigated the influence of age at diagnosis on metastatic BC and patients’ prognosis, and found that elder BC patients were more likely to have lung metastasis, and they had the worst both overall survival and breast cancer-specific survival comparing to younger patients. A population-based observational study also showed that BC patients with different molecular subtypes had different metastasis patterns and survivorship [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Metastasis, characteristic, and treatment of breast cancer in young women and older women: A study from the Surveillance, Epidemiology, and End Results registration database

Gao,

Zhang,

Zhou

et al. 2023

PLoS ONE

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Background Younger age is an independent risk factor for breast cancer (BC) prognosis, and BC in young women is often considered more aggressive. BC patients with different age and molecular subtypes have different metastasis patterns and survival. Herein, we aim to explore the metastasis patterns, characteristics and treatment methods of young patients with BC, and to compare them with older patients. Methods Data of young patients (aged ≤40 years old) and older patients (aged >40 years old) with BC were extracted from the Surveillance, Epidemiology, and End Results (SEER) registration database in 2010–2019 in this retrospective cohort study. Univariate and multivariate competing risk models and proportional hazard models were used to explore the association between different metastasis patterns and treatments and BC prognoses in young and older patients. Kaplan-Meier (KM) curves were drawn to reflect the survival probability of patients with BC who have different metastasis patterns. Also, we performed subgroup analysis of different metastasis patterns to explore the association between different treatments and overall survival (OS)/cancer specific survival (CSS) in patients with BC. The evaluation index was hazard ratios (HRs) with 95% confidence intervals (CIs). Results Totally, 5,984 patients died, and 92.56% of them died from BC. There were respectively 1,089 young patients and 9,105 older patients, and we found some differences of characteristics and metastasis patterns between them. After adjusting for covariates, young patients who had brain metastasis and multiple sites metastasis seemed to have high risk of both lower OS and CSS. Among older patients with BC, brain metastasis, liver metastasis, and multiple sites metastasis were all positively associated with both lower OS and CSS. In young and older patients, those who not receive radiotherapy or surgery, or received non-surgery combined with radiotherapy seemed to have high risk of both lower OS and CSS. Breast-conserving surgery (BCS) and surgery combined with radiotherapy were associated with higher OS and CSS in young patients, while only older patients received surgery combined with radiotherapy had higher OS and CSS. Results of subgroup analysis indicated that for patients with different metastasis patterns, developing a personalized treatment plan is necessary. Conclusions Characteristics of BC between young patients and older patients were different. Clinicians should focus on different metastasis sites and choose appropriate treatments in patients with different ages, which may improve the prognoses.

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Characteristics of metastasis and survival between male and female breast cancer with different molecular subtypes: A population‐based observational study

Cited by 9 publications

References 51 publications

How has the field of metastatic breast cancer in bones evolved over the past 22 years?

How has the field of metastatic breast cancer in bones evolved over the past 22 years?

Male Breast Cancer: An Updated Review of Patient Characteristics, Genetics, and Outcome

Metastasis, characteristic, and treatment of breast cancer in young women and older women: A study from the Surveillance, Epidemiology, and End Results registration database

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