Characteristics of magnetic probes for identifying sentinel lymph nodes

Ookubo, Tetsu; Inoue, Yusuke; Kim, Dongmin; Ohsaki, Hiroyuki; Mashiko, Yusuke; Kusakabe, Moriaki; Sekino, Masaki

doi:10.1109/embc.2013.6610791

Cited by 9 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To enable intraoperative detection of the SLN, handheld magnetometer probes are required in place of gamma probes. A number of magnetometer probe technologies have been proposed using a range of sensing technologies – from Hall effect sensors 8 9 10 and SQUID sensors 11 , to the current embodiment of a commercially available instrument, the SentiMag probe, which uses precisely constructed induction coil sensors 12 . The SentiMag probe provides a notable example of the application of magnetic tracers and magnetometer detection of sentinel nodes and has been demonstrated in a large clinical breast cancer trial 6 and recently, in a clinical prostate cancer trial 7 .…”

mentioning

confidence: 99%

Novel Handheld Magnetometer Probe Based on Magnetic Tunnelling Junction Sensors for Intraoperative Sentinel Lymph Node Identification

Cousins

Balalis

Thompson

et al. 2015

Sci Rep

View full text Add to dashboard Cite

Using magnetic tunnelling junction sensors, a novel magnetometer probe for the identification of the sentinel lymph node using magnetic tracers was developed. Probe performance was characterised in vitro and validated in a preclinical swine model. Compared to conventional gamma probes, the magnetometer probe showed excellent spatial resolution of 4.0 mm, and the potential to detect as few as 5 μg of magnetic tracer. Due to the high sensitivity of the magnetometer, all first-tier nodes were identified in the preclinical experiments, and there were no instances of false positive or false negative detection. Furthermore, these preliminary data encourage the application of the magnetometer probe for use in more complex lymphatic environments, such as in gastrointestinal cancers, where the sentinel node is often in close proximity to other non-sentinel nodes, and high spatial resolution detection is required.

show abstract

mentioning

confidence: 99%

Novel Handheld Magnetometer Probe Based on Magnetic Tunnelling Junction Sensors for Intraoperative Sentinel Lymph Node Identification

Cousins

Balalis

Thompson

et al. 2015

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The structure of existing magnetic probes developed for breast cancer patients, such as DC-probe (developed by us) [26][27][28][29] , Sentimag ® magnetometer 5,30-32 , DiffMag magnetometer 33,34 , fluxgate magnetometer 35 , and a magnetometer based on magnetic tunneling junction sensors 36 , is not applicable for SLN detection in laparoscopic surgery because the typical surgical instruments of laparoscopic surgery are inserted inside the patient's body through a port (a trocar) with an inner diameter of 12 mm; currently, the outer diameter of all probes is larger than 12 mm. Furthermore, eliminating the combined influences from other medical instruments, such as forceps and a laparoscopic camera, is required to more precisely detect SLNs in the limited intra-abdominal space.…”

Section: Development Of Magnetic Probe For Sentinel Lymph Node Detectmentioning

confidence: 99%

Development of Magnetic Probe for Sentinel Lymph Node Detection in Laparoscopic Navigation for Gastric Cancer Patients

Kuwahata

Tanaka

Matsuda

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

New laparoscopic sentinel lymph node navigation using a dedicated magnetic probe and magnetic nanoparticle tracer for gastric cancer patients allows minimally invasive surgeries. By identifying the sentinel lymph nodes containing magnetic nanoparticles, patients can avoid excessive lymph node extraction without nuclear facilities and radiation exposure. This paper describes the development of the laparoscopic magnetic probe, ACDC-probe, for laparoscopic sentinel lymph node identification utilizing the nonlinear response of the magnetic nanoparticles magnetized by an alternating magnetic field with a static magnetic field. For highly sensitive detection, the ratio of static to alternating magnetic fields was optimized to approximately 5. The longitudinal detection length was approximately 10 mm for 140 μg of iron, and the detectable amount of iron was approximately 280 ng at a distance of 1 mm. To demonstrate the feasibility of laparoscopic detection using the ACDC-probe and magnetic tracers, an experiment was performed on a wild swine. The gastric sentinel lymph node was clearly identified during laparoscopic navigation. These results suggest that the newly developed ACDC-probe is useful for laparoscopic sentinel lymph node detection and this magnetic technique appears to be a promising method for future sentinel lymph node navigation of gastric cancer patients.

show abstract

“…The handheld magnetometer used for the detection of the markers was developed by the University of Tokyo (Tokyo, Japan) and consists of a Hall effect sensor inside a permanent magnet. (16) The magnetic flux density measured by the magnetometer is displayed with a scale ranging from 0 to 999 magnetic counts; where a higher count is displayed when the magnetometer is in close proximity of a material with a strong magnetic field. An earlier prototype of this magnetometer was previously validated in a trial evaluating the magnetic technique of SLNB against blue dye as a standard.…”

Section: Magnetometermentioning

confidence: 99%