Characteristics of lipid spectrum and functional liver tests in patients with nonalcoholic liver steatosis depending on degree of obesity during menopause

Abstract

Objective. To study the blood lipid spectrum and functional liver tests in women with nonalcoholic liver steatosis (NALS) depending on the degree of obesity during menopause.
 Materials and methods. Seventy patients with NALS and obesity (NALS-O-M) in menopause with the mean age of 49,9 1,1 years including 24 with increased body mass index (BMI), 20 with the degree 1 obesity, 18 the degree 2 obesity and 8 the degree 3 obesity were examined. The control group involved 30 practically healthy women in menopause without obesity. Blood serum cytolysis, cholestasis and lipid spectrum indicators were studied in both groups.
 Results. According to the results of biochemical investigation, in the group of patients with NALS-O-M syndrome no cytolysis was observed. In case of marked obesity, cholestasis syndrome by the blood alkaline phosphatase level was identified. Lipid spectrum in patients with NALS-O-M statistically significantly differed from the control: hypercholesterinemia, hypertriglyceridemia, increase in the low- and very low-density lipoproteins as well as calculated index of atherogeneity with decrease in the high-density lipoproteins fraction was registered.
 Conclusions. A pronounced obesity causes the cholestasis syndrome with an increase in the blood alkaline phosphatase level. Dyslipidemia of different degree of manifestation is registered in all patients with steatosis and obesity during menopause, being more marked in patients with the degree 23 obesity.