Characteristics of legacy and novel brominated flame retardants in water and sediment surrounding two e-waste dismantling regions in Taizhou, eastern China

Ling, Siyuan; Lü, Cong; Peng, Cheng; Zhang, Wei; Lin, Kuangfei; Zhou, Bingsheng

doi:10.1016/j.scitotenv.2021.148744

Cited by 42 publications

(16 citation statements)

References 64 publications

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“…Decabromodiphenyl ethane (DBDPE), as an alternative to decabromodiphenyl ether (BDE-209), has become one of the most widely applied brominated flame retardants (BFRs). , The large-scale use of DBDPE has rapidly increased the general contamination of environmental media, including air, soil, and water, and relatively high levels of DBDPE have been detected in surface water (107 ng/L) and sediments (218 ng/g dry weight) from Xiaoqing River Basin of China . Notably, in recent studies, DBDPE showed higher persistence in the environment and higher bioavailability in some organisms than its traditional counterpart, BDE-209. , Consequently, it has been generally detected in biological samples from aquatic organisms to mammals, including human breast milk and serum. , With the widespread and continuous use of DBDPE, it would pose increasing exposure to wildlife and humans .…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane-Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae

Yang,

Zhu,

Zhou

et al. 2023

Environ. Sci. Technol.

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Decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, is becoming increasingly prevalent in environmental and biota samples. While DBDPE has been shown to cause various biological adverse effects, the molecular mechanism behind these effects is still unclear. In this research, zebrafish embryos were exposed to DBDPE (50–400 μg/L) until 120 h post fertilization (hpf). The results confirmed the neurotoxicity by increased average swimming speed, interfered neurotransmitter contents, and transcription of neurodevelopment-related genes in zebrafish larvae. Metabolomics analysis revealed changes of metabolites primarily involved in glycolipid metabolism, oxidative phosphorylation, and oxidative stress, which were validated through the alterations of multiple biomarkers at various levels. We further evaluated the mitochondrial performance upon DBDPE exposure and found inhibited mitochondrial oxidative respiration accompanied by decreased mitochondrial respiratory chain complex activities, mitochondrial membrane potential, and ATP contents. However, addition of nicotinamide riboside could effectively restore DBDPE-induced mitochondrial impairments and resultant neurotoxicity, oxidative stress as well as glycolipid metabolism in zebrafish larvae. Taken together, our data suggest that mitochondrial dysfunction was involved in DBDPE-induced toxicity, providing novel insight into the toxic mechanisms of DBDPE as well as other emerging pollutants.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane-Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae

Yang,

Zhu,

Zhou

et al. 2023

Environ. Sci. Technol.

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“…However, in most of the cases evaluated, the FR intake doses were estimated to be substantially below the reference values. In a recent study carried out by Ling et al [ 56 ], the contamination of water and sediments by legacy and novel BFRs was evaluated at two of the world’s largest e-waste dismantling sites located in the Chinese city of Taizhou. According to the results it was found that the concentration of BFRs and NBFRs in the water of both sites were comparable and at the upper end of the global range, while in the sediments there were differences with high concentrations at one site and relatively low concentrations at the other.…”

Section: Weee Recycling As a Source Of Exposure To Bfrs: Health And Environmental Hazardsmentioning

confidence: 99%

Recycling Plastics from WEEE: A Review of the Environmental and Human Health Challenges Associated with Brominated Flame Retardants

Chaine

Hursthouse

McLean³

et al. 2022

IJERPH

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Waste electrical and electronic equipment (WEEE) presents the dual characteristic of containing both hazardous substances and valuable recoverable materials. Mainly found in WEEE plastics, brominated flame retardants (BFRs) are a component of particular interest. Several actions have been taken worldwide to regulate their use and disposal, however, in countries where no regulation is in place, the recovery of highly valuable materials has promoted the development of informal treatment facilities, with serious consequences for the environment and the health of the workers and communities involved. Hence, in this review we examine a wide spectrum of aspects related to WEEE plastic management. A search of legislation and the literature was made to determine the current legal framework by region/country. Additionally, we focused on identifying the most relevant methods of existing industrial processes for determining BFRs and their challenges. BFR occurrence and substitution by novel BFRs (NBFRs) was reviewed. An emphasis was given to review the health and environmental impacts associated with BFR/NBFR presence in waste, consumer products, and WEEE recycling facilities. Knowledge and research gaps of this topic were highlighted. Finally, the discussion on current trends and proposals to attend to this relevant issue were outlined.

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“…Additionally, the concentrations of Cu, Pb, and Cd in scalp hair samples collected at an e‐waste recycling area were found to be higher compared to that in hair samples from Ningbo and Shaoxing, two cities engaged in general industrial activities in China (T. Wang et al., 2009). In this study, we measured concentrations of six heavy metals in human milk samples collected 4 weeks after delivery in Luqiao District, Taizhou City, Zhejiang Province, one of the two largest e‐waste recycling areas in China (Ling et al., 2021), to estimate the associations between prenatal heavy metal exposure and infant birth outcomes.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Heavy Metals and Adverse Birth Outcomes: Evidence From an E‐Waste Area in China

Chen,

Ma,

et al. 2023

GeoHealth

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Electronic waste that has not been properly treated can lead to environmental contamination including of heavy metals, which can pose risks to human health. Infants, a sensitive group, are highly susceptible to heavy metals exposure. The aim of this study was to investigate the association between prenatal heavy metal exposure and infant birth outcomes in an e‐waste recycling area in China. We analyzed cadmium (Cd), chromium (Cr), manganese (Mn), lead (Pb), copper (Cu), and arsenic (As) concentrations in 102 human milk samples collected 4 weeks after delivery. The results showed that 34.3% of participants for Cr, which exceeds the World Health Organization (WHO) guidelines, as well as the mean exposure of Cr exceeded the WHO guidelines. We collected data on the birth weight (BW) and length of infants and analyzed the association between metal concentration in human milk and birth outcomes using multivariable linear regression. We observed a significant negative association between the Cd concentration in maternal milk and BW in female infants (β = −162.72, 95% CI = −303.16, −22.25). In contrast, heavy metals did not associate with birth outcomes in male infants. In this study, we found that 34.3% of participants in an e‐waste recycling area had a Cr concentration that exceeded WHO guidelines, and there was a significant negative association between prenatal exposure to the Cd and infant BW in females. These results suggest that prenatal exposure to heavy metals in e‐waste recycling areas may lead to adverse birth outcomes, especially for female infants.

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Characteristics of legacy and novel brominated flame retardants in water and sediment surrounding two e-waste dismantling regions in Taizhou, eastern China

Cited by 42 publications

References 64 publications

Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane-Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae

Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane-Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae

Recycling Plastics from WEEE: A Review of the Environmental and Human Health Challenges Associated with Brominated Flame Retardants

Prenatal Exposure to Heavy Metals and Adverse Birth Outcomes: Evidence From an E‐Waste Area in China

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