Characteristics of Killer Toxin of the Yeast &amp;lt;i&amp;gt;Cryptococcus pinus&amp;lt;/i&amp;gt;

Kulakovskaya, Ekaterina; Zvonarev, Anton; Farofonova, Vasilina

doi:10.4236/jbm.2019.74008

Cited by 2 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Killer toxin is a toxic protein secreted by yeast that can kill other yeasts but has no killing effect on itself [39]. Lysostaphin can specifically hydrolyze the pentaglycine crosslinks of S. aureus peptidoglycan, resulting in lysis of S. aureus, and has the same bacteriostatic effect on drug-resistant S. aureus [40].…”

Section: Killer Toxin and Lysostaphin Encoding Genesmentioning

confidence: 99%

Whole-Genome Analysis of Starmerella bacillaris CC-PT4 against MRSA, a Non-Saccharomyces Yeast Isolated from Grape

Shen

Bai

Zhou

et al. 2022

JoF

View full text Add to dashboard Cite

Starmerella bacillaris is often isolated from environments associated with grape and winemaking. S. bacillaris has many beneficial properties, including the ability to improve the flavor of wine, the production of beneficial metabolites, and the ability to biocontrol. S. bacillaris CC-PT4 (CGMCC No. 23573) was isolated from grape and can inhibit methicillin-resistant Staphylococcus aureus and adaptability to harsh environments. In this paper, the whole genome of S. bacillaris CC-PT4 was sequenced and bioinformatics analyses were performed. The S. bacillaris CC-PT4 genome was finally assembled into five scaffolds with a genome size of 9.45 Mb and a GC content of 39.5%. It was predicted that the strain contained 4150 protein-coding genes, of which two genes encoded killer toxin and one gene encoded lysostaphin. It also contains genes encoding F1F0-ATPases, Na(+)/H(+) antiporter, cation/H(+) antiporter, ATP-dependent bile acid permease, major facilitator superfamily (MFS) antiporters, and stress response protein, which help S. bacillaris CC-PT4 adapt to bile, acid, and other stressful environments. Proteins related to flocculation and adhesion have also been identified in the S. bacillaris CC-PT4 genome. Predicted by antiSMASH, two secondary metabolite biosynthesis gene clusters were found, and the synthesized metabolites may have antimicrobial effects. Furthermore, S. bacillaris CC-PT4 carried genes associated with pathogenicity and drug resistance. Overall, the whole genome sequencing and analysis of S. bacillaris CC-PT4 in this study provide valuable information for understanding the biological characteristics and further development of this strain.

show abstract

Section: Killer Toxin and Lysostaphin Encoding Genesmentioning

confidence: 99%