Characteristics of intestinal dysbiosis in patients with non-alcoholic fatty liver disease

Фадєєнко, Г. Д.; Gridnyev, Oleksiy; Kushnir, I. E.; Kurinna, O. G.; Chernova, V. M.; Solomentseva, T. A.; Nikiforova, Ya. V.; Galchinska, V. Yu.; Bondar, T. М.

doi:10.30978/mg-2020-6-5

Cited by 1 publication

(2 citation statements)

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“…In a Ukrainian study, patients with NAFLD had a decreased number of Lactobacillus spp. and increased Enterobacter spp./Citrobacter spp., Bacteroides fragilis group with an overall increase in bacterial mass [10]. The increase in the Firmicutes/Bacteroidetes ratio found by us in the studied population of NAFLD patients is primarily characteristic of obesity and its corresponding metabolic disorders and also has a positive correlation with the degree of hepatic steatosis [21; 22].…”

Section: Discussionmentioning

confidence: 98%

“…It is known that metabolic diseases that lead to the development of fatty liver disease and diabetes mellitus, are associated with changes in the composition of intestinal microbiota [9,10]. However, all these studies did not identify separate cohorts of patients with and without diabetes mellitus, so there is still no clear idea of the gut microbiota's contribution to liver damage in diabetes mellitus [11].…”

Section: Introductionmentioning

confidence: 99%

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State of the Gut Microbiota in Patients With Metabolic-Associated Fatty Liver Disease With Type 2 Diabetes Mellitus

Dorofeev

Rudenko²,

Cheverda³

2022

Proc Shevchenko Sci Soc Med Sci

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Introduction. One of the frequent complications of the type 2 diabetes mellitus (T2DM) is a metabolic-associated fatty liver disease (MAFLD). Aim. To study the composition of gut microbiota in patients with a combination of T2DM and MAFLD and to compare it with the microbiota in isolated T2DM and MAFLD. Methods. 111 patients were studied. The main group consisted of 56 patients with a combination of MAFLD and T2DM; the 1st group included 28 patients with MAFLD and the 2nd - 27 patients with T2DM. The control group consisted of 30 practically healthy people. Diagnosis was made by steatometry, shear wave elastography, lactulose H2 breath test, qPCR of feces using primers targeting the 16S rRNA gene, and stool culture. Results. In the the main group SIBO was found in 48.2%, in 1st – 35.7%, in 2nd – 33.3%, compared to 10% in the control group. When compared with healthy people, the number of "other" microorganisms significantly increased in the group with isolated T2DM and Clostridium, Proteus and Candida were cultured; in the case of isolated MAFLD, a decrease in Bacteroidetes and an increase in the Firmicutes/Bacteroidetes ratio, as well as an increase in Klebsiella and Clostridium. In the main group, an increase in Actinobacteria, "other" microorganisms, a ratio of Firmicutes/Bacteroidetes and a decrease in Bacteroidetes were found, when cultured - an increase in Clostridium, Klebsiella and Candida. Conclusions. Only the group of MAFLD with T2DM was characterized by increased Actinobacteria; decreased absolute number of Bifidobacterium and Lactobacillus and increased Escherichia, including with altered enzymatic properties in the stool culture.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%