“…Complexes were analysed by FT‐IR spectroscopy to confirm the chitosan/hyaluronic acid interaction. The shift in amine band to 1547 cm − 1 in the spectrum of complexes indicated a change in environment of amine group through its interaction with hyaluronic acid 19,20 . Moreover, an increased intensity of undissociated carboxyl group band (ν C = O at 1716 cm − 1 ) can be observed in the spectrum of chitosan/hyaluronate complex prepared at pH 2.0.…”
Chitosan/hyaluronate polyelectrolyte complexes can be used for the formulation of mucoadhesive nasal inserts for the delivery of peptide and protein drugs.
“…Complexes were analysed by FT‐IR spectroscopy to confirm the chitosan/hyaluronic acid interaction. The shift in amine band to 1547 cm − 1 in the spectrum of complexes indicated a change in environment of amine group through its interaction with hyaluronic acid 19,20 . Moreover, an increased intensity of undissociated carboxyl group band (ν C = O at 1716 cm − 1 ) can be observed in the spectrum of chitosan/hyaluronate complex prepared at pH 2.0.…”
Chitosan/hyaluronate polyelectrolyte complexes can be used for the formulation of mucoadhesive nasal inserts for the delivery of peptide and protein drugs.
“…The miscibility of materials in polymer blends is dependent on specific interactions between the components such as: the degree of hydrogen bonding, ionic and dipole, p-electron and chargetransfer complexes. From the literature, there is evidence of inter-and intramolecular hydrogen bonding and/or ionic interactions between chitosan and the following homopolymers: silk fibroin, 15 poly(acrylic acid), 16 poly(3-hydroxybutyric acid), 17 poly(ethylene glycol), 18 poly(vinyl pyrrolidone), 19 nylon-4, 20 pectin, 21 poly(caprolactone), 22 poly(vinyl alcohol), 23 and collagen. 24 Chitosan has also been reported to be immiscible with poly(lactic acid), 25 nylon-6, 20 and cellulose.…”
Biocompatible, biodegradable films composed of a hybrid blend of chitosan and egg phosphatidylcholine (ePC) were characterized in terms of composition, morphology, and performance-related properties. The miscibility between chitosan and ePC for blends of 1 : 0.2 to 1 : 2.5 chitosan : ePC (wt/wt) was examined by differential scanning calorimetry and X-ray diffraction analysis. The partial miscibility exhibited between chitosan and ePC provided an understanding of the microdomain morphology that was visualized by laser scanning confocal fluorescence microscopy of the films. The stability of the films in physiologically relevant media was assessed by percent weight loss over time. The mechanical properties of the chitosan-ePC films were determined by dynamic mechanical analysis and tensile tests. Interestingly, the dry film composed of a high lipid formulation (1 : 2.5 (wt/wt) chitosan: ePC) had the lowest tensile strength, contained lipid microdomains (10-30 mm in size), and provided the highest degree of stability. Following immersion in phosphate buffer solution, the Young's modulus of the film was found to decrease by more than two orders of magnitude and could be further manipulated by decreasing the lipid content within the film. In this way, relationships between the composition and the physical as well as mechanical properties of the chitosan-ePC blends were established. Furthermore, this study demonstrates the potential usefulness of partially miscible chitosan-based blends for biomedical purposes.
“…The shift in amine band to 1547 cm -1 in the spectrum of complexes indicated a change in environment of amine group through its interaction with hyaluronic acid. [19,20] Moreover, an increased intensity of undissociated carboxyl group band (n C = O at 1716 cm -1 ) can be observed in the spectrum of chitosan/hyaluronate complex prepared at pH 2.0.…”
Chitosan/hyaluronate polyelectrolyte complexes can be used for the formulation of mucoadhesive nasal inserts for the delivery of peptide and protein drugs.
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