Characteristics of incidence hip fracture cases in older adults participating in the longitudinal AGES-Reykjavik study

Skúladóttir, Sigrún Sunna; Ramel, Alfons; Hjaltadóttir, Ingibjörg; Launer, Lenore J.; Cotch, Mary Frances; Siggeirsdottir, K.; Gudnason, Vilmundur; Sigurðsson, Gunnar; Steingrímsdóttir, Laufey; Halldórsson, Thorhallur I.

doi:10.1007/s00198-020-05567-x

Cited by 8 publications

(9 citation statements)

References 40 publications

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“…(5) The chest X-ray lm showed patchy in ltrates or interstitial changes. After excluding patients with lung cancer, tuberculosis, pulmonary embolism and other pulmonary diseases, in the above items, if the patient meets any of (1)~(4) and also meets item (5), the diagnosis can be con rmed for pulmonary infection.…”

Section: Diagnostic Criteria For Pulmonary Infectionmentioning

confidence: 99%

“…Among them, pulmonary infection is one of the most common complications after hip fracture in the elderly. Once a pulmonary infection occurs, it will seriously affect the patient's postoperative recovery, prolong the hospital stay, increase the cost of hospitalization, and even cause the death of the patient [5,6]. Therefore, the prevention and treatment of postoperative pulmonary infection in patients with hip fractures is of great signi cance to the prognosis of patients.…”

Section: Introductionmentioning

confidence: 99%

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Postoperative Pulmonary Infection in Elderly Patients With Hip Fracture: More Attention Needed

Zheng

2021

Preprint

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Background: Postoperative pulmonary infection is a serious complication in elderly patients with hip fracture, it’s necessary to identify the influencing factors of pulmonary infection in patients with hip fracture.Methods: Elderly patients with hip fractures admitted from January 1, 2020 to July 31, 2021 were included. The characteristics of patients with pulmonary infection and no infection were evaluated and compared. Logistic multivariate regression analyses were conducted to assess the risk factors of pulmonary infection.Results: 267 patients with hip fracture were included, the incidence of pulmonary infection in patients with hip fracture was 13.11%. There were significant differences in the age, diabetes mellitus, anemia, hypoalbuminemia, anesthesia method and duration of surgery between infection and no infection group, no significant differences in the gender, BMI, hypertension, hyperlipidemia, type of fracture, preoperative oxygen saturation, white blood cell count, platelet count, red blood cell count, creatinine, alanine aminotransferase, aspartate aminotransferase, estimated blood loss during surgery were detected between infection and no infection group. Logistic regression analysis showed that age≥70y(OR2.326 , 95%CI1.248~3.129), diabetes mellitus(OR2.123, 95%CI1.021~3.551), anemia(OR3.199,95%CI1.943~5.024), hypoalbuminemia(OR2.377, 95%CI1.211~3.398), general anesthesia(OR1.947, 95%CI1.115~3.038), duration of surgery≥120min(OR1.621 , 95%CI1.488~2.534) were the risk factors of pulmonary infection in elderly patients with hip fracture(all p<0.05). Escherichia Coli(33.33%), Klebsiella pneumoniae(28.57%), Staphylococcus aureus(21.43%) were the most common bacteria of pulmonary infection.Conclusion: There are many risk factors for pulmonary infection in elderly patients with hip fractures after surgery. In clinical practice, medical workers should take targeted interventions for those risk factors to reduce the risk of pulmonary infection.

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Section: Diagnostic Criteria For Pulmonary Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Postoperative Pulmonary Infection in Elderly Patients With Hip Fracture: More Attention Needed

Zheng

2021

Preprint

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“…Combined with the critical loss of bone mass, an increased propensity for falls due to deterioration of physical function can lead to the increased incidence of fractures in older people, especially in the hip area. 1,2 There is an increased concern that about one-third of communitydwelling adults aged≥65 years in western countries fall each year and the frequency of falls and fall-related injuries increase with age. 3 Cerebrovascular diseases, as one of the common diseases that endanger the health of older adults, are at high risk of imbalance or falls, which in turn significantly aggravating their condition and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characteristics of Fall-Related Fractures in Older Adults with Cerebrovascular Disease: A Cross-Sectional Study

Guo

Zhao

et al. 2021

CIA

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Limited information exists on fall-related fractures in older adults with cerebrovascular disease. This study aimed to determine the characteristics of older adults with cerebrovascular disease who sustained fall-related fractures and identify the associated risk factors for perioperative complications. Patients and Methods: This was a cross-sectional study, which included patients with cerebrovascular disease who sustained fractures between Jan. 2017 and Dec. 2019. The collected data included demographics (age and gender), time and place of fracture occurrence, mechanism of injury, fracture location, type of cerebrovascular disease, complications, and comorbidities. Results: A total of 768 patients with 815 fractures were included; there were 253 males and 515 females, with an average age of 78.3 years. For either males or females, 80-84 years was the most commonly involved age group. Most (61.0%) patients had their fractures occurring at home and most fractures (70.7%) occurred during the daytime. Most were hip fractures and limb weakness; instability-related falls were the most common cause of fracture, making a proportion of 34.5%. Patients who suffered falls were mainly combining ischemic cerebrovascular disease. Most (85.9%) patients presented with at least one comorbid disease and the perioperative complication rate was 76.9% in total cases. Age≥80 (OR: 1.772, 95% CI: 1.236-2.540) and the number of comorbidities≥3 (OR: 1.606, 95% CI: 1.035-2.494) were found independently associated with complications, while the type of cerebrovascular disease, fracture location, and comorbidities of prior fragility fracture and respiratory disease were not significantly correlated with complications. Conclusion: Our findings highlighted that more focus on improved physical function explored in intervention setting and the importance of primary home prevention measures seems justified in China and maybe other countries as well. It is the first study that presented the epidemiological characteristics of older adults with cerebrovascular disease who later experienced a fracture.

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“…A later study, from the same cohort identified poor physical function as one of the main characteristics of hip fracture cases compared to non-cases. (22) Based on these observations, the aim of this study was to examine to what extent measurements of bone mass and markers of physical function might, when considered jointly, explain the inverse associations between serum 25(OH)D and incidence hip fracture in this older population.…”

Section: Introductionmentioning

confidence: 99%

Serum 25-Hydroxy-Vitamin D Status and Incident Hip Fractures in Elderly Adults: Looking Beyond Bone Mineral Density

Skúladóttir

Ramel

Eymundsdottir³

et al. 2020

Journal of Bone and Mineral Research

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Observational studies have consistently reported a higher risk of fractures among those with low levels of serum 25-hydroxyvitamin D (25(OH)D). Emerging evidence suggests that low serum 25(OH)D levels may increase the rate of falls through impaired physical function. Examine to what extent baseline measures of volumetric bone mineral density (vBMD), absolute bone mineral content (BMC), and markers of physical function may explain incident hip fractures in older adults with different serum levels of 25(OH)D. A prospective study of 4309 subjects (≥66 years) recruited between 2002 and 2006 into the Age, Gene/Environment Susceptibility-Reykjavik (AGES-Reykjavik) study. Hip fractures occurring until the end of 2012 were extracted from hospital records. Prevalence of serum 25(OH)D deficiency (<30 nmol/L), inadequacy (30-<50 nmol/L), and sufficiency (≥50 nmol/L) was 6%, 23%, and 71% for males; and 11%, 28%, and 53% for females, respectively. Female participants had ~30% lower absolute BMC compared to males. Serum 25(OH)D concentrations were positively associated with vBMD and BMC of the femoral neck and markers of physical function, including leg strength and balance. Those who had deficient compared to sufficient status at baseline had a higher age-adjusted risk of incidence hipfractures with hazard ratios (HRs) of 3.1 (95% confidence interval [CI], 1.9-5.2) and 1.8 (95% CI, 1.3-2.5) among males and females, respectively. When adjusting for vBMD and measures of physical function, the association was attenuated and became nonsignificant for males (1.3; 95% CI, 0.6-2.5) but remained significant for females (1.7; 95% CI, 1.1-2.4). Deficient compared to sufficient serum 25(OH)D status was associated with a higher risk of incident hip fractures. This association was explained by poorer vBMD and physical function for males but to a lesser extent for females. Lower absolute BMC among females due to smaller bone volume may account for these sex-specific differences.

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Characteristics of incidence hip fracture cases in older adults participating in the longitudinal AGES-Reykjavik study

Cited by 8 publications

References 40 publications

Postoperative Pulmonary Infection in Elderly Patients With Hip Fracture: More Attention Needed

Postoperative Pulmonary Infection in Elderly Patients With Hip Fracture: More Attention Needed

Characteristics of Fall-Related Fractures in Older Adults with Cerebrovascular Disease: A Cross-Sectional Study

Serum 25-Hydroxy-Vitamin D Status and Incident Hip Fractures in Elderly Adults: Looking Beyond Bone Mineral Density

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