Characteristics of <i>Enterobacteriaceae</i> Isolates Coharboring Distinct Carbapenemase Genes

Rozales, Franciéli Pedrotti; Lovison, Otávio von Ameln; Magagnin, Cibele Massotti; Martins, Alejandro; Crispim, Marina Niada; Zavascki, Alexandre Prehn; Barth, Afonso Luís

doi:10.1017/ice.2017.146

Infect. Control Hosp. Epidemiol.

2017

DOI: 10.1017/ice.2017.146

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Characteristics of Enterobacteriaceae Isolates Coharboring Distinct Carbapenemase Genes

Franciéli Pedrotti Rozales

Otávio von Ameln Lovison

Cibele Massotti Magagnin

et al.

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“…Relatively few studies have reported Enterobacterales isolates harboring more than one carbapenemase gene. Rozales et al described the characteristics of 10 Enterobacterales coharboring carbapenemase genes: 5 E. cloacae complex with bla NDM-1 and bla OXA-370 genes, 3 K. pneumoniae and 1 E. cloacae complex with bla NDM-1 and bla KPC-2 genes, and 1 K. pneumoniae with bla KPC-2 and bla OXA-370 genes [7]. Balm et al and Both et al reported a K. pneumoniae isolate co-harboring bla NDM and bla OXA-181 genes and a E.coli coproducing bla NDM-1 and bla OXA-232 , respectively [8,9].…”

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Increased frequency of blaNDM in a tertiary care hospital in southern Brazil

et al. 2021

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Resistance to carbapenems due to metallo-beta-lactamase NDM-1 was first described in Brazil in 2013. To date, only a few scattered reports of the prevalence of NDM-1 in the country have been reported, and most of them indicated a very low prevalence of this metalloenzyme. In the present study, we report a steady increase in the frequency of NDM among Enterobacterales resistant to carbapenems in a tertiary care hospital in southern Brazil. Carbapenemase genes were evaluated by multiplex real-time polymerase chain using high-resolution melting analysis among 3501 isolates of 8 different species of Enterobacterales recovered from January 2015 to May 2020. The bla KPC-like was identified in 3003 isolates (85.8%) and the bla NDM-like was the second most common gene (351 isolates-10%). There was a steady increase in frequency of bla NDM-like , from 4.2% in 2015 to 24% in 2020. The increase of bla NDM frequency raises an important matter as novel therapeutic options are currently very limited for the treatment of patients infected by bacteria carrying the bla NDM .

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Increased frequency of blaNDM in a tertiary care hospital in southern Brazil

et al. 2021

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Occurrence of high-risk clones of Klebsiella pneumoniae ST11, ST340, and ST855 carrying the blaKPC-2, blaNDM-1, blaNDM-5, and blaNDM-7 genes from colonized and infected patients in Brazil

de Oliveira,

Beltrão,

Pimentel

et al. 2023

Journal of Applied Microbiology

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Aims Determine which ST clones were carrying the blaKPC, blaNDM, blaVIM, blaIMP and blaGES genes and their variants in clinical isolates of multidrug resistant K. pneumoniae. Methods and Results Ten K. pneumoniae isolates were obtained from the colonized and infected patients in a public hospital in the city of Recife-PE, in northeastern Brazil, and were further analyzed. The detection of carbapenem resistance genes and the 7 housekeeping genes (for MLST detection) were done with PCR and sequencing. The blaKPC and blaNDM genes were detected concomitantly in all isolates, with variants being detected blaNDM-1, blaNDM-5, blaNDM-7 and blaKPC-2. The blaKPC-2 and blaNDM-1 combination being the most frequent. Molecular typing by MLST detected three types of high-risk ST clones, associated with the clonal complex 258, ST11/CC258 in eight isolates, and ST855/CC258 and ST340/CC258 in the other two isolates. Conclusions These findings are worrying, as they have a negative impact on the scenario of antimicrobial resistance, and show the high genetic variability of K. pneumoniae and its ability to mutate resistance genes and risk of dissemination via different ST clones.

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Characteristics of Enterobacteriaceae Isolates Coharboring Distinct Carbapenemase Genes

Cited by 2 publications

References 10 publications

Increased frequency of blaNDM in a tertiary care hospital in southern Brazil

Increased frequency of blaNDM in a tertiary care hospital in southern Brazil

Occurrence of high-risk clones of Klebsiella pneumoniae ST11, ST340, and ST855 carrying the blaKPC-2, blaNDM-1, blaNDM-5, and blaNDM-7 genes from colonized and infected patients in Brazil

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