Characteristics of Hepatitis B Virus Isolates of Genotype G and Their Phylogenetic Differences from the Other Six Genotypes (A through F)

Kato, Hideaki; Orito, Etsuro; Gish, Robert G.; Sugauchi, Fuminaka; Suzuki, Seiji; Ueda, Ryuzo; Miyakawa, Yuzo; Mizokami, Masashi

doi:10.1128/jvi.76.12.6131-6137.2002

Cited by 116 publications

(130 citation statements)

References 29 publications

(56 reference statements)

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…HBV genotype G has been associated with the presence of two stop codons in the pre-core region, which could prevent HBeAg production (Kato et al 2002). The two infected patients with genotype G were positive for HBeAg, but as genotype G does not produce this antigen, a co-infection with another genotype is possible.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiencyvirus/hepatitis B virus co-infected patients in Brazil

Silva

Spina

Lemos

et al. 2010

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

In this study, we evaluated the hepatitis B virus (HBV) genotype distribution and HBV genomic mutations among a group of human immunodeficiency virus-HBV co-infected patients from an AIDS outpatient clinic in São Paulo. HBV serological markers were detected by commercially available enzyme immunoassay kits. HBV DNA was detected using in-house nested polymerase chain reaction and quantified by Cobas Amplicor. HBV genotypes and mutations in the basal core promoter (BCP)/pre-core/core regions and surface/polymerase genes were determined by sequencing. Among the 59 patients included in this study, 55 reported prior use of lamivudine (LAM) or tenofovir. HBV DNA was detected in 16/22 patients, with a genotype distribution of A (n = 12,75%), G (n = 2,13%), D (n = 1,6%) and F (n = 1,6%). The sequence data of the two patients infected with genotype G strongly suggested co-infection with genotype A. In 10 patients with viremia, LAM-resistance mutations in the polymerase gene (rtL180M + rtM204V and rtV173L + rtL180M + rtM204V) were found, accompanied by changes in the envelope gene (sI195M, sW196L and sI195M/sE164D). Mutations in the BCP and pre-core regions were identified in four patients. In conclusion, genotype G, which is rarely seen in Brazil, was observed in the group of patients included in our study. A high prevalence of mutations associated with LAM-resistance and mutations associated with anti-HBs resistance were also found among these patients

show abstract

Section: Discussionmentioning

confidence: 99%

Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiencyvirus/hepatitis B virus co-infected patients in Brazil

Silva

Spina

Lemos

et al. 2010

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…Epidemiological and clinical data regarding this genotype are limited, likely due to the low prevalence of HBV/G throughout the world . HBV/G infection has been frequently reported to be detected along with a co-infecting functional HBV strain, such as genotype A (Kato et al, 2002a) or genotype H (Sánchez et al, 2007); however, HBV/G monoinfection has also been described (Alvarado-Esquivel et al, 2006;Chudy et al, 2006;Pas et al, 2008). Recombination between HBV/ G and the co-infecting genotype has been observed, but normally as a minority species within the HBV quasispecies population (Kato et al, 2002b).…”

mentioning

confidence: 99%

“…Hepatitis B virus (HBV) genotype G (HBV/G) has only recently been discovered (Stuyver et al, 2000); it is characterized by a unique 36 bp insertion downstream of the core gene start codon and by mutations preventing expression of hepatitis B e-antigen (HBeAg) (Kato et al, 2002a). Epidemiological and clinical data regarding this genotype are limited, likely due to the low prevalence of HBV/G throughout the world .…”

mentioning

confidence: 99%

Hepatitis B virus genotype G epidemiology and co-infection with genotype A in Canada

Osiowy

Gordon²,

Borlang³

et al. 2008

Journal of General Virology

View full text Add to dashboard Cite

Hepatitis B virus (HBV) genotype G (HBV/G) is an unusual variant, and little is known about its epidemiology and natural history, particularly the requirement for a co-infecting HBV genotype and their relationship during infection. This study investigated the quasispecies nature of coinfecting genotypes in 39 samples collected over a 6 year period from 13 HBV/G-infected patients. HBV/G infections were found to occur predominantly in males (92 %) and were primarily associated with male homosexual sex (67 %). All patients were infected with HBV/G and HBV/A, or a recombinant HBV/A/G strain. Co-infecting genotypic prevalence was often observed to fluctuate over time, with periods of HBV/G monoinfection in some patients. The average sequence divergence among Canadian HBV/G strains was 1.57±0.62 %. Thus, all HBV/G infections in Canada occur in the context of co-infection or recombination with HBV/A, and strains display increased sequence divergence compared with all known HBV/G sequences described to date.

show abstract

“…28 In 2000, a unique HBV isolate harboring a 36-base pair insertion in the core region was identified in France; this was the first isolate of genotype G. 6 The S gene of HBV/G is highly homologous (94.6-97.5%) with that of HBV/A at the nucleotide (nt) level. 29 Subsequently, HBV/G was identified in the United States, 30,31 Mexico, 32 Germany, 33 Canada, 28 and Brazil. 34 A previous study estimated the prevalence of HBV/G in these areas to be 1-5%.…”

mentioning

confidence: 99%

Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men

Kojima

Kawahata

Mori

et al. 2015

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

The rare hepatitis B virus (HBV) genotype G (HBV/G) coinfects HIV-1-positive individuals along with HBV/A and generates recombinants. However, the circulation of HBV A/G recombinants remains poorly understood. This molecular epidemiologic study examined HBV A/G recombinants in Japanese HIV-1-positive men who have sex with men (MSM). Initially, blood specimens submitted for confirmatory tests of HIV infection in Osaka and Tokyo, Japan, from 2006 to 2013 were examined for HIV-1, and HIV-1-positive specimens were screened for HBV. Among

show abstract

Characteristics of Hepatitis B Virus Isolates of Genotype G and Their Phylogenetic Differences from the Other Six Genotypes (A through F)

Abstract: Eight hepatitis B virus (HBV) isolates

Cited by 116 publications

References 29 publications

Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiencyvirus/hepatitis B virus co-infected patients in Brazil

Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiencyvirus/hepatitis B virus co-infected patients in Brazil

Hepatitis B virus genotype G epidemiology and co-infection with genotype A in Canada

Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men

Contact Info

Product

Resources

About