Characteristics of hematopoietic stem cells of umbilical cord blood

Hordyjewska, Anna; Popiołek, Łukasz; Horecka, Anna

doi:10.1007/s10616-014-9796-y

Cited by 84 publications

(85 citation statements)

References 28 publications

(50 reference statements)

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“…Moreover, cord blood differs from bone marrow and peripheral blood with respect to the number of colony forming cells. Cord blood contains 8.000 BFU-E forming cells, between 13.000 and 24.000 CFU-GM and between 1.000 and 10.000 CFU-GEMM forming cells in 1 ml of blood which is 3 and 15 times more than the numbers in marrow and peripheral blood, respectively [20,27,28]. The number of cells expressing the surface antigen CD34 in cord blood lies between 0.02 and 1.43%, which is close to the values in bone marrow cells (0.5-5%) but different from peripheral blood (<0.01%) [20,29].…”

Section: Cd38mentioning

confidence: 98%

“…Due to their more naïve characteristics and their availability, HSCs from cord blood are widely used in research. However, there are some differences compared to peripheral blood and bone marrow such as differences in the composition, number and properties of the cells [20][21][22][23][24]. CD34 +…”

Section: Hematopoietic Stem Cellsmentioning

confidence: 99%

“…-cells, locked in the G 0 -phase of the cell cycle, show a greater proliferative response to cytokines and are less dependent on stromal cells than the corresponding cells in the bone marrow or peripheral blood [20,[24][25][26]. Moreover, cord blood differs from bone marrow and peripheral blood with respect to the number of colony forming cells.…”

Section: Cd38mentioning

confidence: 99%

“…+ CD38 -cells in cord blood is higher than in bone marrow (4% compared to 1%) [20,30]. Adhesion receptors play a major role in the hematopoietic process.…”

Section: Hla-drmentioning

confidence: 99%

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Artificial Hematopoietic Stem Cell Niches-Dimensionality Matters

Gottwald¹

2017

ATROA

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Hematopoietic stem cell niches are perhaps the best described niche system in mammals. The niches themselves, as well as their cellular and structural constituents and factors that play a role in maintaining the niche structure and function, are being refined on a more or less daily basis. Despite this, it seems as if the more we know the harder it gets to mimic the in vivo-situation using in vitro-systems. This is due to the fact that hematopoiesis is a multi step maturation process leading to HSC heterogeneity. Subpopulations of HSCs and niche supporting cells can be defined depending on characteristics such as their potency of leading to successful reconstitution of sub lethally irradiated mice in serial transplantation experiments or, with less scientific impact, clonogenic assays. Since the bone marrow obviously provides all necessary information to maintain the stem cell pool constant and to adapt the number of blood cells according to physiologic needs, it has been the goal to engineer artificial niches that display at least one or several of the major characteristics of the in vivosituation to make use of these systems for not only fundamental research purposes but, moreover, also for clinical applications. This review will give an overview of approaches to engineering artificial hematopoietic niches with a focus on the complexity/dimensionality of the systems used.

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Section: Cd38mentioning

confidence: 98%

Section: Hematopoietic Stem Cellsmentioning

confidence: 99%

Section: Cd38mentioning

confidence: 99%

“…+ CD38 -cells in cord blood is higher than in bone marrow (4% compared to 1%) [20,30]. Adhesion receptors play a major role in the hematopoietic process.…”

Section: Hla-drmentioning

confidence: 99%

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Artificial Hematopoietic Stem Cell Niches-Dimensionality Matters

Gottwald¹

2017

ATROA

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“…These HSC are also present in umbilical cord blood. 1 Umbilical Cord Blood (UCB) is a good source of hematopoietic stem cells (HSCs) that is equivalent to those found in the bone marrow. After delivery, umbilical cord blood can be collected and cryopreserved which can be used later.…”

Section: Introductionmentioning

confidence: 99%

Awareness of cord blood banking among pregnant women in semi urban area

Poomalar

Jayasree

2016

Int J Reprod Contracept Obstet Gynecol

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Personalized prediction of overall survival in patients with AML in non‐complete remission undergoing allo‐HCT

et al. 2021

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Allogenic hematopoietic stem cell transplantation (allo‐HCT) is the standard treatment for acute myeloid leukemia (AML) in non‐complete remission (non‐CR); however, the prognosis is inconsistent. This study aimed to develop and validate nomograms and a web application to predict the overall survival (OS) of patients with non‐CR AML undergoing allo‐HCT (cord blood transplantation [CBT], bone marrow transplantation [BMT], and peripheral blood stem cell transplantation [PBSCT]). Data from 3052 patients were analyzed to construct and validate the prognostic models. The common significant prognostic factors among patients undergoing allo‐HCT were age, performance status, percentage of peripheral blasts, cytogenetic risk, chemotherapy response, and number of transplantations. The conditioning regimen was a significant prognostic factor only in patients undergoing CBT. Compared with cyclophosphamide/total body irradiation, a conditioning regimen of ≥3 drugs, including fludarabine, with CBT exhibited the lowest hazard ratio for mortality (0.384; 95% CI, 0.266–0.554; p < 0.0001). A conditioning regimen of ≥3 drugs with CBT also showed the best leukemia‐free survival among all conditioning regimens. Based on the results of the multivariable analysis, we developed prognostic models showing adequate calibration and discrimination (the c‐indices for CBT, BMT, and PBSCT were 0.648, 0.600, and 0.658, respectively). Our prognostic models can help in assessing individual risks and designing future clinical studies. Furthermore, our study indicates the effectiveness of multi‐drug conditioning regimens in patients undergoing CBT.

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Characteristics of hematopoietic stem cells of umbilical cord blood

Cited by 84 publications

References 28 publications

Artificial Hematopoietic Stem Cell Niches-Dimensionality Matters

Artificial Hematopoietic Stem Cell Niches-Dimensionality Matters

Awareness of cord blood banking among pregnant women in semi urban area

Personalized prediction of overall survival in patients with AML in non‐complete remission undergoing allo‐HCT

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