Characteristics of gut microbiota in patients with gastric cancer by surgery, chemotherapy and lymph node metastasis

Chen, Changchang; Shen, Jian; Du, Yaoqiang; Shi, Xinwei; Niu, Yaofang; Jin, Gulei; Liu, Yanxin; Shi, Yongkang; Lyu, Jianxin; Lin, Lijun

doi:10.1007/s12094-022-02875-y

Cited by 11 publications

(6 citation statements)

References 34 publications

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“… 53 The RF model trained using fecal microbiome data also classified surgical GC patients from non-surgical patients with an AUC of 0.75. 56 These studies indicate that fecal microbiota may be an indicator of gastric dysbiosis, providing the possibility for noninvasive microbiome diagnosis.…”

Section: Discussionmentioning

confidence: 93%

Meta-analysis reveals Helicobacter pylori mutual exclusivity and reproducible gastric microbiome alterations during gastric carcinoma progression

Zhan

et al. 2023

Gut Microbes

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Section: Discussionmentioning

confidence: 93%

Meta-analysis reveals Helicobacter pylori mutual exclusivity and reproducible gastric microbiome alterations during gastric carcinoma progression

Zhan

et al. 2023

Gut Microbes

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“…A limited number of studies have analyzed changes in the microbiota after surgical treatment for oncologic diseases ( Tong et al, 2020 ; Chen et al, 2022 ; Hajjar et al, 2023 ). Research has shown that the microbial community after surgery is similar to that of healthy individuals, which can promote the recovery of tumor patients ( Wolfe and Markey, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of mastectomy on gut microbiota and its metabolites in patients with breast cancer

Fan,

Ding,

et al. 2024

Front. Microbiol.

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BackgroundThe relationship between gut microbiota and breast cancer has been extensively studied; however, changes in gut microbiota after breast cancer surgery are still largely unknown.Materials and methodsA total of 20 patients with breast cancer underwent routine open surgery at the First Affiliated Hospital of Hainan Medical College from 1 June 2022 to 1 December 2022. Stool samples were collected from the patients undergoing mastectomy for breast cancer preoperatively, 3 days later, and 7 days later postoperatively. The stool samples were subjected to 16s rRNA sequencing.ResultsSurgery did not affect the α-diversity of gut microbiota. The β-diversity and composition of gut microorganisms were significantly affected by surgery in breast cancer patients. Both linear discriminant analysis effect size (LEfSe) analysis and between-group differences analysis showed that surgery led to a decrease in the abundance of Firmicutes and Lachnospiraceae and an increase in the abundance of Proteobacteria and Enterobacteriaceae. Moreover, 127 differential metabolites were screened and classified into 5 categories based on their changing trends. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed significant changes in the phenylalanine metabolic pathway and exogenous substance metabolic pathway. Eight characterized metabolites were screened using ROC analysis.ConclusionOur study found that breast cancer surgery significantly altered gut microbiota composition and metabolites, with a decrease in beneficial bacteria and an increase in potentially harmful bacteria. This underscores the importance of enhanced postoperative management to optimize gut microbiota.

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“…The impact of anticancer treatment on the composition of the gut microbiome appears to be less significant than that of surgery. Chen et al [ 34 ] analyzed fecal samples from 157 gastric cancer patients, categorizing them based on whether they underwent surgery or received anticancer treatment, which included chemotherapy and immunotherapy. Notably, patients who underwent surgery exhibited a substantial difference in fecal microbiome composition compared to those who didn’t.…”

Section: Gut Microbiome After Anticancer Treatmentmentioning

confidence: 99%

Unveiling the Gastrointestinal Microbiome Symphony: Insights Into Post-Gastric Cancer Treatment Microbial Patterns and Potential Therapeutic Avenues

Park

2024

J Gastric Cancer

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This review delved into the intricate relationship between the gastrointestinal microbiome and gastric cancer, particularly focusing on post-treatment alterations, notably following gastrectomy, and the effects of anticancer therapies. Following gastrectomy, analysis of fecal samples revealed an increased presence of oral cavity aerotolerant and bile acid-transforming bacteria in the intestine. Similar changes were observed in the gastric microbiome, highlighting significant alterations in taxon abundance and emphasizing the reciprocal interaction between the oral and gastric microbiomes. In contrast, the impact of chemotherapy and immunotherapy on the gut microbiome was subtle, although discernible differences were noted between treatment responders and non-responders. Certain bacterial taxa showed promise as potential prognostic markers. Notably, probiotics emerged as a promising approach for postgastrectomy recovery, displaying the capacity to alleviate inflammation, bolster immune responses, and maintain a healthy gut microbiome. Several strains, including Bifidobacterium , Lactobacillus , and Clostridium butyricum , exhibited favorable outcomes in postoperative patients, suggesting their potential roles in comprehensive patient care. In conclusion, understanding the intricate interplay between the gastrointestinal microbiome and gastric cancer treatment offers prospects for predicting responses and enhancing postoperative recovery. Probiotics, with their positive impact on inflammation and immunity, have emerged as potential adjuncts in patient care. Continued research is imperative to fully harness the potential of microbiome-based interventions in the management of gastric cancer.

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Characteristics of gut microbiota in patients with gastric cancer by surgery, chemotherapy and lymph node metastasis

Cited by 11 publications

References 34 publications

Meta-analysis reveals Helicobacter pylori mutual exclusivity and reproducible gastric microbiome alterations during gastric carcinoma progression

Meta-analysis reveals Helicobacter pylori mutual exclusivity and reproducible gastric microbiome alterations during gastric carcinoma progression

Effect of mastectomy on gut microbiota and its metabolites in patients with breast cancer

Unveiling the Gastrointestinal Microbiome Symphony: Insights Into Post-Gastric Cancer Treatment Microbial Patterns and Potential Therapeutic Avenues

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