Characteristics of Greek male patients with primary biliary cholangitis

Azariadis, Kalliopi; Lygoura, Vasiliki; Zachou, Kalliopi; Arvaniti, Pinelopi; Saitis, Asterios; Gatselis, Nikolaos; Dalekos, G.N.

doi:10.1016/s0168-8278(17)31515-5

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“…4,26 This finding coincides with a recent Greek clinical study, in which, after adjusting for other confounding factors including alcohol consumption, male sex did not independently pose a greater risk for disease progression during follow-up evaluation. 27 Of note, in accordance with our findings, a recent study from GPBCSG did not associate sex with response and transplant-free survival. 28 Strengths of our study were the inclusion of a large cohort of PBC patients from different geographic areas as well as long-term follow-up evaluation with many clinical events.…”

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confidence: 92%

Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis

Gatselis

Goet

Zachou

et al. 2020

Clinical Gastroenterology and Hepatology

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BACKGROUND & AIMS:Patients usually receive a diagnosis of primary biliary cholangitis (PBC) at an early stage, based on biochemical analyses. We investigated the proportion of patients who progress to moderate or advanced PBC and factors associated with progression and patient survival. METHODS:We obtained data from 1615 patients (mean age, 55.4 y) with early stage PBC (based on their normal levels of albumin and bilirubin), collected at the time of initial evaluation or treatment, from the Global PBC Study Group database (comprising patients at 19 liver centers in North American and European countries). We collected data from health care evaluations on progression to moderate PBC (abnormal level of bilirubin or albumin) or advanced-stage PBC (abnormal level of both). The median follow-up time was 7.9 years. The composite end point was decompensation, hepatocellular carcinoma, liver transplantation, or death. RESULTS:Of the 1615 patients identified with early stage PBC, 904 developed moderate PBC and 201 developed advanced disease over the study period. The proportions of patients who transitioned to moderate PBC at 1, 3, and 5 years were 12.9%, 30.2%, and 45.8%. The a Authors share co-first authorship.

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