Characteristics of Gastric Cancer in Lebanon: a Descriptive Study from a Single Institutional Experience

Assi, Tarek; Rassy, Elie El; Khazzaka, Aline; Moussa, Tania; Ibrahim, Tony; Kattan, Clarisse; Karak, Fadi El; Farhat, Fadi; Ghosn, Marwan; Kattan, Joseph

doi:10.1007/s12029-016-9903-8

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…According to a Lebanese single-institution descriptive study, the incidence of gastric cancer in the Lebanese population ranked seventh in males and tenth in females with an average of 240 cases per year (equivalent to 5–7 per year per 100,000 inhabitants); trends were not studied [19]. According to our present study, we confirm that both GA incidence and incidence rate have decreased in central Tunisia, starting from the year 2009.…”

Section: Discussionsupporting

confidence: 47%

Gastric Adenocarcinomas in Central Tunisia: Evolution Specificities through Two Decades and Relation with Helicobacter pylori

et al. 2018

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Introduction: In developed countries, authors have reported variations over time in the seat and histological type of gastric adenocarcinomas, which were explained by Helicobacter pylori infection (HPI) incidence changes. In North-African countries and the Arabic world, epidemiological changes in gastric adenocarcinomas are still unknown. Our study aims to explore and to describe those changes in central Tunisia. Materials and Methods: This is a retrospective observational and descriptive study including 876 cases based on the National Central Tunisian Register of Cancers over a period of 21 years. Two groups were formed and compared (group A: 337 patients from 1995 to 2005; group B: 539 patients from 2006 to 2015). Results: HPI decreased from 32.6% in group A to 11.2% in group B (p < 0.05). Signet ring cell carcinomas increased in 2 decades from 14% in group A to 36% in group B (p < 0.05). Proximal cancers were 16.61% in group A and increased to 19.66% in group B (p = 0.3). Total gastrectomy rate was 10.4% in group A versus 23.2% in group B (p < 0.05). Conclusion: This study has shown a significant increase of signet ring cell carcinomas with a simultaneous decrease in HPI in the last decade in central Tunisia.

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Section: Discussionsupporting

confidence: 47%

Gastric Adenocarcinomas in Central Tunisia: Evolution Specificities through Two Decades and Relation with Helicobacter pylori

et al. 2018

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“…To our knowledge, only one study examined the clinical and demographic characteristics of patients with GC in Lebanon (2). However, it did not examine the effect of age on prognosis.…”

Section: Original Articlementioning

confidence: 99%

“…According to a recent national epidemiological study and records from the Lebanese Ministry of Health, cancer incidence in Lebanon is among the highest in the region and is expected to remain high over the coming decade (1). Specifically, there was an increase in the age-standardized incidence rates of gastric cancer (GC) between 2003 and 2008, from 6.2 to 8.1 cases per 100,000 among males, and from 5.1 to 6.7 cases per 100,000 among females (1,2). In Lebanon, there are on average 240 cases of GC per year, and GC ranks as the seventh and tenth most common cause of cancer among males and females, respectively (3).…”

Section: Introductionmentioning

confidence: 99%

The impact of age on prognosis in patients with gastric cancer: experience in a tertiary care centre

Halabi¹,

Horanieh²,

Tamim³

et al. 2020

J Gastrointest Oncol

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Background: Gastric cancer (GC) is a leading cause of cancer-related death in the world and most patients have advanced disease upon presentation. The effect of age on prognosis in GC is controversial. We aimed to determine the impact of age on survival in patients with GC.Methods: This was a retrospective study of the medical records of Lebanese patients diagnosed with GC at the American University of Beirut Medical Center (AUBMC) between 2005 and 2014. Patients were divided into young (<65 years) and older groups (≥65 years). A multivariate analysis was done to determine the independent predictors of survival. Kaplan-Meier method was used for analysis of long-term survival outcomes. Results:The sample consisted of 156 patients. The mean age was 62.15 (SD 13.54). Most patients presented with stage 4 disease (62.2%) and poorly differentiated histology (66.4%). The most common symptoms were abdominal pain and weight loss. On bivariate analysis, advanced stage (P=0.02) and higher grade (P=0.04) were associated with increased mortality. Patients <65 years of age were significantly more likely to have poorly differentiated tumours, while patients ≥65 years had more comorbidities (P=0.001). The 5-year DFS were 35% and 37% for patients <65 years of age and ≥65 years of age, respectively (P=0.15). Conclusions:Higher grade and advanced stage are associated with worse survival in patients with GC, but age did not seem to have an impact. Screening high risk patients and early diagnosis are necessary to improve survival.

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“…This could be due to differences in lifestyle, including drinking, smoking, or increased stress levels in men, which have been linked to the early development of gastric cancer. 10 On observing the various risk factors for gastric cancer, majority of the patients in our study were exposed to smoking tobacco with 57% of smokers. Chewing tobacco was observed in 39% of them whereas 42% consumed alcohol regularly.…”

Section: Discussionmentioning

confidence: 92%

Management and outcomes of carcinoma stomach in Central India: a prospective cross-sectional study

2021

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Background: Adenocarcinoma of the stomach is one of the leading causes of cancer-related deaths worldwide. Cancer rates in India are rising with increase in life expectancy and changes in lifestyles. Although the incidence of gastric cancer has decreased, number of newly diagnosed cases of proximal gastric and esophago-gastric junction adenocarcinomas has increased markedly. It is necessary to identify the population and risk factors along with malignancy characteristics in Central India.Methods: A prospective observational study of 84 histopathological proven cases of gastric malignancy were analysed and evaluated. Treatment for the same was categorised after staging. Surgical resection, therapeutic and palliative chemotherapy was employed in the treatment protocols. A follow-up of 6 months was taken to observe the early complications.Results: Eighty-four patients were analysed and evaluated. The mean age was 54.1 year with male predominance (1.54:1). Hypertension was commonest comorbidity, while smoking was commonest associated risk factor observed. Majority (56%) of patients underwent palliative chemotherapy while 34% underwent curative surgery. Subtotal gastrectomy with Billiroth II gastrojejunostomy was commonest performed operation (34%). Postoperative wound infection was commonest complication. Mean follow-up period of 11.3 months was observed where one patient expired of ARDS and one was readmitted for anastomotic site stricture.Conclusions: There was high incidence of gastric malignancy patients presenting in stage IV in 5th decade of life with weight loss as main feature. Palliative chemotherapy is commonly followed because of advanced disease. The rates of inoperability are high and unfavourable histopathological variety occur frequently in older patients.

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Characteristics of Gastric Cancer in Lebanon: a Descriptive Study from a Single Institutional Experience

Abstract: Gastric cancer in the Lebanese population is characterized by aggressive features such as advanced stage at diagnosis, high prevalence of diffuse type histology, and HER2 positivity.

Cited by 9 publications

References 25 publications

Gastric Adenocarcinomas in Central Tunisia: Evolution Specificities through Two Decades and Relation with <b><i>Helicobacter pylori</i></b>

Gastric Adenocarcinomas in Central Tunisia: Evolution Specificities through Two Decades and Relation with <b><i>Helicobacter pylori</i></b>

The impact of age on prognosis in patients with gastric cancer: experience in a tertiary care centre

Management and outcomes of carcinoma stomach in Central India: a prospective cross-sectional study

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