Characteristics of field-effect devices with gate oxide modification by DNA

Abstract

Current-voltage characterization was used to investigate the behavior of silicon field-effect devices with DNA solutions of various concentrations and molecular states deposited on the gate oxide. These devices were similar to conventional transistors but without gate metal, and no surface treatments or agents were used to immobilize the DNA. With increasing micromolar concentration, significant changes were produced in the device response. The current decreased with increasing ratios of double-to-single stranded populations produced by mixing complementary sequences, and by thermal denaturing. The device characteristics were reproducible. Modeling suggested a mechanism of modifications to the device carrier density induced by variations in the electrochemical properties of the DNA located within a charge screening length of the gate oxide surface. These results showed that field-effect devices may be useful for the real time monitoring of nucleic acids, without binding agents or label tags.

Optical detection of deoxyribonucleic acid hybridization with InGaN∕GaN multiple quantum wells

“…To demonstrate our working principle, a probe chip based on In 0.22 Ga 0.78 N / GaN multiple quantum wells has been constructed and exposed to target DNA solutions, matched and/or mismatched, with different concentrations. [7][8][9][10][11] In x Ga 1−x N / GaN multiple quantum wells ͑MQWs͒ have been widely used for the application of light emitting devices ͑LEDs͒ and laser diodes. The results shown here open up a new possibility for the application of nitride LEDs in biosensor engineering.…”

Terahertz Sensing of Materials

“…Label-free DNA detection has attracted tremendous research effort in recent years for its non-invasive, fast and low cost advantages [3][4][5]. In this study we explore the possibility of gaining information about the DNA through its interaction with Terahertz radiation.…”

DNA hybridization sensor based on AlGaN/GaN HEMT

“…Most of these methods include using a labeling agent [6] or are expensive, time consuming, tedious and destructive. Semiconductor-based biosensorsare better than the above mentioned procedures since they are label free, nondestructive and fast [7][8][9][10].…”