Characteristics of Extended-Gate Field-Effect Transistor (EGFET) Based on Porous n-Type (111) Silicon for Use
in pH Sensors

Ahmed, Naser M.; Kabaa, E.A.; Jaafar, Mohammad Suhaimi; Omar, Ahmad

doi:10.1007/s11664-017-5604-8

Cited by 25 publications

(15 citation statements)

References 37 publications

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“…The resulting electric field modifies the conductance of the field effect transistor (FET), and the current flowing in the channel between the source and the drain terminals is used to measure pH. 17 The ISFET is another technique where the whole transistor is immersed in the solution and its gate dielectric is exposed, i.e., replacing the transistor gate with the electrolyte. As H + ions accumulate on the ISFET's gate dielectric, the resulting electric field modulates the current in the channel.…”

Section: Overviewmentioning

confidence: 99%

“…EGFET pH sensors use the physical protonation and deprotonation reactions that cause a difference in the surface potentials at the interface between the electrolyte solution and the extended gate of a transistor. The resulting electric field modifies the conductance of the field effect transistor (FET), and the current flowing in the channel between the source and the drain terminals is used to measure pH . The ISFET is another technique where the whole transistor is immersed in the solution and its gate dielectric is exposed, i.e., replacing the transistor gate with the electrolyte.…”

Section: Materials For Electrochemical Ph Sensorsmentioning

confidence: 99%

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Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

et al. 2019

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pH-sensing materials and configurations are rapidly evolving toward exciting new applications, especially those in biomedical applications. In this review, we highlight rapid progress in electrochemical pH sensors over the past decade (2008–2018) with an emphasis on key considerations, such as materials selection, system configurations, and testing protocols. In addition to recent progress in optical pH sensors, our main focus in this review is on electromechanical pH sensors due to their significant advances, especially in biomedical applications. We summarize developments of electrochemical pH sensors that by virtue of their optimized material chemistries (from metal oxides to polymers) and geometrical features (from thin films to quantum dots) enable their adoption in biomedical applications. We further present an overview of necessary sensing standards and protocols. Standards ensure the establishment of consistent protocols, facilitating collective understanding of results and building on the current state. Furthermore, they enable objective benchmarking of various pH-sensing reports, materials, and systems, which is critical for the overall progression and development of the field. Additionally, we list critical issues in recent literary reporting and suggest various methods for objective benchmarking. pH regulation in the human body and state-of-the-art pH sensors (from ex vivo to in vivo) are compared for suitability in biomedical applications. We conclude our review by (i) identifying challenges that need to be overcome in electrochemical pH sensing and (ii) providing an outlook on future research along with insights, in which the integration of various pH sensors with advanced electronics can provide a new platform for the development of novel technologies for disease diagnostics and prevention.

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Section: Overviewmentioning

confidence: 99%

Section: Materials For Electrochemical Ph Sensorsmentioning

confidence: 99%

Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

et al. 2019

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“…Some of the brain sections were tested by IHC and HE staining as some previous reports presented. 33 Statistical Analysis. All experimental results were expressed as mean ± SD.…”

Section: ■ Introductionmentioning

confidence: 99%

High-Performance Extended-Gate Field-Effect Transistor for Kinase Sensing in Aβ Accumulation of Alzheimer’s Disease

2022

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An amyloid-beta peptide (Aβ) is generally believed to be a pathological marker of Alzheimer's disease (AD), but it is still of great significance to explore the upstream and downstream relationship of Aβ in AD. It is previously reported that c-Abl, a nonreceptor tyrosine kinase, can be activated by Aβ, but the interaction between Aβ and c-Abl is still unknown. Herein, an extended-gate field-effect transistor (EG-FET)based sensor has been developed to monitor the level of c-Abl with high sensitivity and selectivity. Our peptide-functionalized EG-FET sensor as the signal transducer can follow c-Abl activity with electron transfer by its specific phosphorylation. The sensor presents a good linear correlation over c-Abl concentrations of 1 pg/mL to 3.05 μg/mL. The sensor was successfully applied to quantify c-Abl activity in the brain tissue of AD transgenic mice, and the interaction between c-Abl and Aβ in AD mice was explored by administering the c-Abl inhibitor (imatinib) and the agonist (DPH). Our work is expected to provide an important reference for early diagnosis and treatment of AD.

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“…Nessa configuração é proporcionada uma ampla região de detecção permitindo também a utilização de amostras maiores, sem que haja a limitação do tamanho do MOSFET [7].…”

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“…A medida de pH está relacionada à variação no potencial de superfície devido à interação do eletrólito com a porta do transistor, produzindo assim um campo elétrico que afeta a condutância do canal FET [8]. Dessa maneira, ocorre uma variação na corrente que flui entre os terminais de dreno e fonte (I DS ) do MOSFET, permitindo relacionar esta corrente com a concentração iônica da solução eletrolítica [7].…”

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Eletrodeposição de filmes finos de ZnO para o desenvolvimento de sensores de pH

Rodrigues¹,

Batista²

2019

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A medida de pH tem grande relevância em diversas áreas que vão desde a química analítica até a indústria farmacêutica. O desenvolvimento de dispositivos sensores de pH que possam substituir os eletrodos combinados de vidro tradicionais tem sido almejado por diversos grupos de pesquisa, principalmente após a proposta do MOSFET sensível a íons (ISFET), na década de 1970. Diante disso, o objetivo central deste trabalho é contribuir para o desenvolvimento nas pesquisas de sensores de pH baseados em transistores de efeito de campo com porta estendida -EGFET. Para tal, este trabalho se divide em duas etapas: a fabricação de filmes finos de ZnO, em substrato de FTO, através da eletrodeposição potenciostática, e a caracterização dos filmes como sensores de pH. Foi obtida, com a caracterização elétrica dos filmes, uma sensibilidade na ordem de 56,25 mV/pH com filmes de ZnO eletrodepositados a 80 o C, com faixa de medida do pH 2 ao pH 10. Serão abordadas também a caracterização morfológica e estrutural dos filmes, bem como a caracterização elétrica dos mesmos aplicados como sensores de pH.

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Characteristics of Extended-Gate Field-Effect Transistor (EGFET) Based on Porous n-Type (111) Silicon for Use in pH Sensors

Cited by 25 publications

References 37 publications

Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

Recent Progress in Electrochemical pH-Sensing Materials and Configurations for Biomedical Applications

High-Performance Extended-Gate Field-Effect Transistor for Kinase Sensing in Aβ Accumulation of Alzheimer’s Disease

Eletrodeposição de filmes finos de ZnO para o desenvolvimento de sensores de pH

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