Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

Suwannarin, Neeranuch; Prapamontol, Tippawan; Isobe, Takeshi; Nishihama, Yukiko; Nakayama, Shoji F.

doi:10.3390/ijerph17217871

Cited by 12 publications

(16 citation statements)

References 53 publications

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“…The structured questionnaire was modified from the pilot study [ 31 ]. Reliability and validity were tested as quality control (QC) of the questionnaire.…”

Section: Methodsmentioning

confidence: 99%

“…Urinary OP metabolites including dimethylphosphate (DMP), dimethylthiophosphate (DMTP), diethylphosphate (DEP), diethylthiophosphate (DETP) and diethyldithiophosphate (DEDTP) were measured by gas chromatography with a flame photometric detector according to the previously established method using an Agilent 7890-B GC system (Agilent Technologies, Inc., Santa Clara, CA, USA) [ 34 ]. The procedure was briefly described in our previous study [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

“…Urinary NEO/m including ACE, CLO, dinotefuran (DIN), flonicamid (FLN), IMI, nitenpyram (NIT), sulfoxaflor (SUF), thiacloprid (THI), thiamethoxam (THX), desmethyl- CLO (dm-CLO), N-desmethyl-ACE (N-dm-ACE), imidacloprid-olefin (Of-IMI) and thiacloprid-amide (THI-AM) were measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The procedure used a Nexera liquid chromatography system coupled to a Triple Quad 8060 mass spectrometer (Shimadzu Corporations, Kyoto, Japan) and was briefly described in our previous study [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

“…We previously reported that Thai reproductive-aged farmworkers are exposed to OPs and NEOs based on measurement of urinary dialkylphosphates (DAPs), nonspecific metabolites of OPs, and NEOs and their metabolites (NEO/m) [ 31 ]. In that study, we found that exposure to NEOs is related to alterations of red blood cell indices in male farmworkers (a separate manuscript is being prepared).…”

Section: Introductionmentioning

confidence: 99%

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Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

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Several studies indicated organophosphate (OP) and neonicotinoid (NEO) insecticides are endocrine disruptors; however, data are scarce. This cross-sectional study recruited 143 male farmworkers aged 18–40 years in Fang district, Chiang Mai province, northern Thailand. OP exposure was assessed by measuring urinary dialkylphosphate (DAPs) using a gas-chromatography flame photometric detector. Urinary NEOs, their metabolites (NEO/m) and serum steroid hormones were measured using liquid chromatography–tandem mass spectrometry. Characteristics of participants were determined by face-to-face interviews. DAPs and five NEO/m were detected in more than 60% of samples. The concentration of diethylphosphate was highest among DAP metabolites (geometric mean concentration (GM: 23.9 ng/mL) and the concentration of imidacloprid (IMI) was highest among NEO/m (GM: 17.4 ng/mL). Linear regression models showed that the IMI level was positively associated with testosterone, dehydrocorticosterone (DHC) and dehydroepiandrosterone (DHEA) levels. Imidacloprid-olefin and DHEA levels were positively associated. Thiamethoxam (THX) were inversely associated with DHC and deoxycorticosterone levels. Clothianidin (CLO), THX and N-desmethyl-acetamiprid levels were positively associated with the androstenedione level. CLO and THX levels were inversely associated with the cortisone level. In conclusion, the association between NEO insecticides exposure and adrenal androgens, glucocorticoids and mineralocorticoids, suggest potential steroidogenesis activities. Our findings warrant further investigation.

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“…The structured questionnaire was modified from the pilot study [ 31 ]. Reliability and validity were tested as quality control (QC) of the questionnaire.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

Self Cite

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“…Recently, increasing numbers of epidemiological studies have demonstrated the impacts of OPPs on neurodevelopment in children [ 3 , 4 , 5 ] and via prenatal exposure [ 6 ]. Some studies reported that human exposure to OPPs is associated with the season; intake of certain food items, such as vegetables (tomato and sweet pepper), fruits (apple, banana, citrus, kiwi and apricot), beans, bread and drinking water; and the use of pesticides in workplaces [ 7 , 8 , 9 ]. Similar results were obtained from large-scale birth cohort studies [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Nishihama

Nakayama

Isobe

et al. 2021

IJERPH

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Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10.

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Estimation of the Effects of Neonicotinoid Insecticides on Wild Raccoon, Procyon lotor, in Hokkaido, Japan: Urinary Concentrations and Hepatic Metabolic Capability of Neonicotinoids

Shinya

Sashika

Minamikawa

et al. 2022

Enviro Toxic and Chemistry

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Toxicological effects of neonicotinoid insecticides (NNIs) have been reported for mammals, such as humans, rats, and mice. However, there are limited reports on their toxic effects on wild mammals. To predict NNI‐induced toxic effects on wild mammals, it is necessary to determine the exposure levels and metabolic ability of these species. We considered that raccoons could be an animal model for evaluating NNI‐induced toxicities on wildlife because they live near agricultural fields and eat crops treated with NNIs. The objective of the present study was to estimate the effects of NNI exposure on wild raccoons. Urinary concentrations of NNI compounds (n = 59) and cytochrome P450‐dependent metabolism of NNIs (n = 3) were evaluated in wild raccoons captured in Hokkaido, Japan, in 2020. We detected either one of the six NNIs or one metabolite, including acetamiprid, imidacloprid, clothianidin, dinotefuran, thiacloprid, thiamethoxam, and desmethyl‐acetamiprid in 90% of raccoons (53/59); the average cumulative concentration of the seven NNI compounds was 3.1 ng/ml. The urinary concentrations were not much different from those reported previously for humans. Furthermore, we performed an in vitro assessment of the ability of raccoons to metabolize NNIs using hepatic microsomes. The amounts of NNI metabolites were measured using liquid chromatography–electrospray ionization–tandem mass spectrometry and compared with those in rats. Raccoons showed much lower metabolic ability; the maximum velocity/Michaelis–Menten constant (Vmax/Km) values for raccoons were one‐tenth to one‐third of those for rats. For the first time, we show that wild raccoons could be frequently exposed to NNIs in the environment, and that the cytochrome P450‐dependent metabolism of NNIs in the livers of raccoons might be low. Our results contribute to a better understanding of the effects of NNIs on raccoons, leading to better conservation efforts for wild mammals. Environ Toxicol Chem 2022;41:1865–1874. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

Cited by 12 publications

References 53 publications

Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Estimation of the Effects of Neonicotinoid Insecticides on Wild Raccoon, Procyon lotor, in Hokkaido, Japan: Urinary Concentrations and Hepatic Metabolic Capability of Neonicotinoids

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