Characteristics of epitopes of limited variability on the head of influenza H1 haemagglutinin
Jose Lourenco,
Hany Zinad,
James Kempton
et al.
Abstract:It is commonly assumed that all naturally protective targets of immunity in influenza are highly variable. Our theoretical work suggests, by contrast, that influenza evolution is primarily driven by naturally protective immune responses against epitopes of limited variability (ELV). We have identified and characterised at least one such ELV on the head region of the major influenza antigen, haemagglutinin (HA), of H1 influenza, opening up the possibility of a novel method of producing a universal influenza vac… Show more
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