Characteristics of Enteral Pathobiome in Extensive Purulent Peritonitis With Complicated Acute Enteral Insufficiency Syndrome

Parshin, Dmitry; Topchiev, Mikhail; Misrikhanov, Misrikhan; Topchiev, A.M.; Pyatakov, S. N.; Chechukhina, O.B.; Smirnyagina, E.O.

doi:10.17513/spno.30960

Cited by 1 publication

(1 citation statement)

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“…These cross coupling interactions have a great influence on the formation of the function of the host's immune system and, ultimately, on the outcome of interventions. Evidence suggests that pathogens derived from the gut microbiota can cause postoperative infection while they stealthily travel inside an immune cell and contaminate a remote surgical site (Trojan horse hypothesis) [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Results of the Use of Polyvalent Bacteriophages in the Treatment of Infectious Complications in Emergency Abdominal Surgery

Parshin,

Mykhaylichenko,

Kupriyanov

et al. 2023

ArveMED

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We comparatively studied the results of treatment of 86 patients with surgical infectious complications after cavitary intra-abdominal operations for emergency abdominal diseases. In the main group, treatment was supplemented with polyvalent bacteriophages. We studied integral scales for assessing the severity of patient’s condition of (APACHE II, ACI, ASEPSIS), microbial pattern, enteral morphofunctional coefficient, levels of alkaline phosphatase and intestinal alkaline phosphatase, and indicators of cellular immunity. The results of the study show that complex treatment including polyvalent bacteriophages in postoperative purulent-inflammatory complications in urgent surgery reduces the development of antibiotic-resistant strains, as well as the risk of nosocomial microbial wound associations. Enteral application of polyvalent bacteriophages in patients with acute intestinal failure syndrome normalizes microbial enteral imbalance and the level of pathogens contamination of the small intestine. Supplementing the treatment of postoperative abdominal purulent-inflammatory complications with phage therapy can reduce the number of surgical interventions, as well as the treatment duration and mortality.

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