Characteristics of EEG power spectrum during sleep spindle events in ADHD children

Dea, Federica De; Zanus, Caterina; Carrozzi, Marco; Stecca, Matteo; Accardo, Agostino

doi:10.1109/embc.2018.8512486

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…When the power of slow sleep spindles during stage 2 NREM sleep was evaluated, Saito et al (2019) found that the ratio of 12-Hz frontal spindle power was higher in 5 to 13-year-old ADHD ( n = 21) than in the typically developing children ( n = 18) (especially for children with ADHD with comorbid ASD), and also that the ratio of 12-Hz spindles was significantly correlated with reaction time variability on a CPT to measure attention. EEG power spectral analysis revealed significant differences concentrated in the period immediately after spindle epochs, in the left hemisphere of the brain, in almost all bands, with greater values in control ( n = 7) than in children with ADHD ( n = 8) among 6 to 10 year olds (De Dea et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…Kirov et al, 2012, report greater REM duration in ADHD). For NREM features, lower periodic EEG activity (Cyclic Alternating Pattern, CAP) for stage 2 sleep was indicated along with higher 12 Hz frontal spindle power for ADHD children when compared to controls and its significant positive relationship with reaction time variability measuring attention (Akinci et al, 2015; De Dea et al, 2018; Grissom et al, 2009; Saito et al, 2019; Silvestri et al, 2009). Lower CAP rate was also found by Miano et al (2006) in children with ADHD, perhaps indicating hyperarousal during NREM sleep in these children.…”

Section: Discussionmentioning

confidence: 98%

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A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

2021

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Objective: Children and adults with ADHD often report sleep disturbances that may form part of the etiology and/or symptomatology of ADHD. We review the evidence for sleep changes in children with ADHD. Methods: Systematic review with narrative synthesis assessing sleep and circadian function in children aged 5 to 13 years old with a diagnosis of ADHD. Results: 148 studies were included for review, incorporating data from 42,353 children. We found that sleep disturbances in ADHD are common and that they may worsen behavioral outcomes; moreover, sleep interventions may improve ADHD symptoms, and pharmacotherapy for ADHD may impact sleep. Conclusion: Sleep disturbance may represent a clinically important feature of ADHD in children, which might be therapeutically targeted in a useful way. There are a number of important gaps in the literature. We set out a manifesto for future research in the area of sleep, circadian rhythms, and ADHD.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

2021

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“…There is one study which reported decreased sigma activity during sleep stage 2 [31]. Another study reported that sleep spindles are accompanied by reduced oscillatory brain activity before and after the spindle in children with ADHD [32]. In our previous studies, we did not observe such quantitative differences in sleep architecture.…”

Section: Introductionmentioning

confidence: 49%

Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults

et al. 2019

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Sigma power during sleep is associated with cognitive abilities in healthy humans. We examined the relationship between sigma power in sleep EEG and intelligence and alertness in schoolchildren with ADHD (n = 17) in comparison to mentally healthy children (n = 16) and adults (n = 23). We observed a positive correlation between sigma power in sleep stage 2 and IQ in healthy adults but a negative correlation in children with ADHD. Furthermore, children with ADHD showed slower reaction times in alertness testing than both control groups. In contrast, only healthy children displayed a positive correlation between sigma power and reaction times. These data suggest that the associations between sigma power and cognitive performance underlie distinct developmental processes. A negative association between IQ and sigma power indicates a disturbed function of sleep in cognitive functions in ADHD, whereas the function of sleep appears to be matured early in case of motor-related alertness performance.

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“…Lastly, spindles appear to be promising biomarkers of various psychiatric conditions as well, such as schizophrenia, depression and ADHD (Ferrarelli et al 2007;Lopez and Hoffmann 2010;Plante et al 2013;De Dea et al 2018;Merikanto et al 2019). Most of these studies report reduced spindle occurrence and/or amplitude, as we observe in aging (Ferrarelli et al 2007;Lopez and Hoffmann 2010;Merikanto et al 2019).…”

Section: Predictive/external Validity: What Predicts Spindle Expressi...mentioning

confidence: 63%

The dog as a model-animal in comparative sleep spindle research

Borislavov¹

2020

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Dr. Enikő Kubinyi, who supervised this thesis and the efforts that are described hereafter. She trusted my ability when my curriculum vitae could not speak up for me, yet, and provided the necessary means and support for this project to work. Our written exchanges while working on manuscripts together, helped me develop ideas and map my way through the relevant literature. She took the time and patience to review and promote all ideas that came to my mind, while making sure the most urgent goals do not leave our sight. Dr. Gilles van Luijtelaar, who supervised my bachelor and master theses. Who took the time to discuss neuroscience on almost philosophical levels of depth and continued to support me, morally and academically, long after his official role as my teacher had ended. His dry and confrontational, yet cordial humor were always uplifting the spirit of our interactions. Dr. Hein van Schie who supervised my first literature study in psychology and continued to explore ideas with me long after I left the Radboud University of Nijmegen. One of our literature studies became my first publication, which helped me regain confidence in a difficult time. Dr. Torfi Sigurdsson, who after a time that was hard for both of us, did not take it personal that we were a bad match.From the senior university teachers/professors with whom I interacted, but were not my direct/official supervisors I would like to thank:Dr. Arno Koning who first taught me academic writing, the late Dr. Jacques Janssen, Dr. Pieter Medendorp and his then PhD students, now Dr. Frank Léoné and Dr. Ivar Clemens who taught me to use Matlab, our faculty's Statistics professor Dr. Jules Ellis, Dr. Tineke van Rijn for knowing how to ignite interest in brain anatomy and physiology, all of above associated with the Radboud University of Nijmegen. Dr. Jochen Roeper who kept up the intellectual spirit in the otherwise worldly Frankfurt. In the ELTE department of ethology I also had the honor to meet and learn from Dr. Ádám Miklósi, Dr. Attila Andics (whose efforts in organizing the department retreats gave me a chance to socialize more directly with many colleagues), Dr. Péter Pongrácz (whom I thank a visit to a life animal market and my first experiences as a peer-reviewer), Dr. Ákos Pogány and Dr. Tamás Faragó (these two I want to also thank specifically for engaging the department in short-lived, but fun musical projects). I am also grateful for meeting Dr. Claudia Fugazza and Dr. Márta Gácsi and having the opportunity to ask some direct questions about their interesting lines of work. A very special thanks also to Dr. Dorottya Júlia Ujfalussy, for helping out with some highly relevant bureaucratic pressures right in the beginning of my stay (but in that regard also I want to mention and thank Boróka Bereczky, Ágnes Modrovics and Borbála Győri).I would next like to thank a few personal friends from within academia, who at times unofficially acted as "secondary" or "supporting" supervisors, as well as those who worked with me towards shared goals:

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Characteristics of EEG power spectrum during sleep spindle events in ADHD children

Cited by 4 publications

References 14 publications

A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults

The dog as a model-animal in comparative sleep spindle research

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