Characteristics of DPOAE audiogram in tinnitus patients

Shiomi, Yosaku; Tsuji, Jun; Naito, Yasushi; Fujiki, Nobuya; Yamamoto, Norio

doi:10.1016/s0378-5955(97)00043-9

Cited by 92 publications

(90 citation statements)

References 20 publications

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“…However, this is a rather incomplete and thus poor assessment of hearing for the following reasons: (1) in almost all individuals with tinnitus whose hearing thresholds according their audiograms were regarded to be within normal limit had abnormal distortion product of otoacoustic emissions (Shiomi et al, 1997) indicating outer hair cell dysfunction. (2) Sharp increased thresholds assessed via the threshold equalizing noise (TEN) test were found in young individuals with tinnitus who had normal (clinical) audiograms, a finding which implies deafferentation (probably inner hair cell damage) in a circumscribed frequency range .…”

Section: Deafferentation Is Essentialmentioning

confidence: 99%

The relevance of spontaneous activity for the coding of the tinnitus sensation

Weisz

Dohrmann

Elbert

2007

Progress in Brain Research

149

133

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In this chapter we will present support for the hypothesis that synchronous neuronal activity of cell assemblies within the auditory cortex could be the underlying neural code of tinnitus. Such synchronous activity is reflected in the ongoing oscillatory activation pattern that can be recorded non-invasively using MEG and EEG techniques. We conclude that such an oscillatory model of tinnitus can explain many different observations regarding tinnitus.

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Section: Deafferentation Is Essentialmentioning

confidence: 99%

The relevance of spontaneous activity for the coding of the tinnitus sensation

Weisz

Dohrmann

Elbert

2007

Progress in Brain Research

149

133

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“…In addition, distortion products, which are thought to reflect the operation of the nonlinear cochlear amplifier, are selectively altered for frequency bands that have been matched to the tinnitus percept [63][64][65] . Finally, release from masking by a secondary masking tone does not occur in tinnitus subjects, indicating once again that the nonlinear effect of this two-tone suppression ascribed to the cochlear amplifier is not operating in tinnitus subjects 66,67 .…”

Section: A Evidence Related To Tinnitus and Hearing Lossmentioning

confidence: 99%

Illusory percepts from auditory adaptation

Parra

Pearlmutter

2007

The Journal of the Acoustical Society of America

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Phenomena resembling tinnitus and Zwicker phantom tone are seen to result from an auditory gain adaptation mechanism that attempts to make full use of a fixed-capacity channel. In the case of tinnitus, the gain adaptation enhances internal noise of a frequency band otherwise silent due to damage. This generates a percept of a phantom sound as a consequence of hearing loss. In the case of Zwicker tone, a frequency band is temporarily silent during the presentation of a notched broad-band sound, resulting in a percept of a tone at the notched frequency. The model suggests a link between tinnitus and the Zwicker tone percept, in that it predicts different results for normal and tinnitus subjects due to a loss of instantaneous nonlinear compression. Listening experiments on 44 subjects show that tinnitus subjects (11 of 44) are significantly more likely to hear the Zwicker tone. This psychoacoustic experiment establishes the first empirical link between the Zwicker tone percept and tinnitus. Together with the modeling results, this supports the hypothesis that the phantom percept is a consequence of a central adaptation mechanism confronted with a degraded sensory apparatus.

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“…Attempts to resolve this problem have been made using distortion product otoacoustic emissions (DPOAE) in subjects with normal audiograms. However results have been ambiguous, showing decreases (Shiomi et al, 1997) as well as increases of outer-hair cell activity in the tinnitusfrequency region (Gouveris et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

High-frequency tinnitus without hearing loss does not mean absence of deafferentation

et al. 2006

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A broad consensus within the neuroscience of tinnitus holds that this audiologic condition is triggered by central deafferentation, mostly due to cochlear damage. The absence of audiometrically detectable hearing loss however poses a challenge to this rather generalizing assumption. The aim of this study was therefore to scrutinize cochlear functioning in a sample of tinnitus subjects audiometrically matched to a normal hearing control group. Two tests were applied: the Threshold Equalizing Noise (TEN) test and a pitch scaling task. To perform well on both tasks relatively normal functioning of inner hair cells is a requirement. In the TEN test the tinnitus group revealed a circumscribed increment of thresholds partially overlapping with the tinnitus spectrum. Abnormal slopes were observed in the pitch scaling task which indicated that tinnitus subjects, when presented with a high-frequency stimulus, relied heavily on input derived from lower-frequency inner hair cells (off-frequency listening). In total both results argue for the presence of a deafferentation also in tinnitus subjects with audiometrically normal thresholds and therefore favour the deafferentation assumption posed by most neuroscientific theories.

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Characteristics of DPOAE audiogram in tinnitus patients

Cited by 92 publications

References 20 publications

The relevance of spontaneous activity for the coding of the tinnitus sensation

The relevance of spontaneous activity for the coding of the tinnitus sensation

Illusory percepts from auditory adaptation

High-frequency tinnitus without hearing loss does not mean absence of deafferentation

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