Characteristics of DNA methylation changes induced by traffic-related air pollution

Ding, Rui; Jin, Yaqing; Liu, Xinneng; Zhu, Ziyi; Zhang, Yuan; Wang, Ting; Xu, Yuzi

doi:10.1016/j.mrgentox.2015.12.002

Cited by 56 publications

(35 citation statements)

References 37 publications

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“…These abnormalities have been implicated in the effect of air pollution on carcinogenesis [104] and respiratory failure [105,106]. In rats exposed to PM2.5, PM10 and NO 2 , Ding et al have demonstrated both hypomethylation and hypermethylation of certain genes [107]. These changes can also affect mitochondrial (mt) DNA [108].…”

Section: Epigenetic Modificationsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

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Section: Epigenetic Modificationsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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“…A number of the genes were identified to be involved in tumor suppression, including deleted in malignant brain tumors 1, ERBB receptor feedback inhibitor 1 and gap junction protein β2. Another study observed gene methylation in healthy mice exposed to traffic-associated air pollution, including upregulation of p16 and adenomatous polyposis coli methylation, and downregulation of long interspersed nuclear element-1 and nitric oxide synthase 2 methylation (48). It has been demonstrated that following exposure to PM2.5, DNA methylation of tandem repeats increases (49).…”

Section: Pm25-induced Tumor Suppressor Gene Inactivation Throughmentioning

confidence: 99%

Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases (Review)

2018

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Previous research has identified that air pollution is associated with various respiratory diseases, but few studies have investigated the function served by particulate matter 2.5 (PM2.5) in these diseases. PM2.5 is known to cause epigenetic and microenvironmental alterations in lung cancer, including tumor-associated signaling pathway activation mediated by microRNA dysregulation, DNA methylation, and increased levels of cytokines and inflammatory cells. Autophagy and apoptosis of tumor cells may also be detected in lung cancer associated with PM2.5 exposure. A number of mechanisms are involved in triggering and aggravating asthma and COPD, including PM2.5-induced cytokine release and oxidative stress. The present review is an overview of the underlying molecular mechanisms of PM2.5-induced pathogenesis in lung cancer and chronic airway inflammatory diseases.

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“…It has been further suggested that BDNF production is epigenetically mediated, wherein increased DNA methylation results in lower BDNF mRNA levels. Moreover, preliminary research has demonstrated that traffic-related air pollutants moderate DNA methylation (113,114).…”

Section: Respiratory Systemmentioning

confidence: 99%

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

Ragguett

Danielle

Subramaniapillai

et al. 2017

Reviews on Environmental Health

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Objective: Risk factors for suicide can be broadly categorized as sociodemographic, clinical and treatment. There is interest in environmental risk and protection factors for suicide. Emerging evidence suggests a link between environmental factors in the form of air pollution and aeroallergens in relation to suicidality. Methods: Herein, we conducted a systematic review of 15 articles which have met inclusion criteria on the aforementioned effects. Results: The majority of the reviewed articles reported an increased suicide risk alongside increased air pollutants or aeroallergens (i.e. pollen) increase; however, not all environmental factors were explored equally. In specific, studies that were delimited to evaluating particulate matter (PM) reported a consistent association with suicidality. We also provide a brief description of putative mechanisms (e.g. inflammation and neurotransmitter dysregulation) that may mediate the association between air pollution, aeroallergens and suicidality. Conclusion:Available evidence suggests that exposure to harmful air quality may be associated with suicidality. There are significant public health implications which are amplified in regions and countries with greater levels of air pollution and aeroallergens. In addition, those with atopic sensitivity may represent a specific subgroup that is at risk.

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Characteristics of DNA methylation changes induced by traffic-related air pollution

Cited by 56 publications

References 37 publications

Does air pollution play a role in infertility?: a systematic review

Does air pollution play a role in infertility?: a systematic review

Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases (Review)

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

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