Characteristics of dialysis-related amyloidosis in patients on haemodialysis therapy for more than 30 years

Otsubo, Shigeru; Naoki, Katsuhiko; Okutsu, Ichiro; Oshikawa, Kazunori; Ueda, Syuitsu; Sugimoto, H.; Mitobe, Michihiro; Uchida, Keiko; Otsubo, Kimiko; Nitta, Kosaku; Akiba, Takashi

doi:10.1093/ndt/gfn706

Cited by 47 publications

(38 citation statements)

References 15 publications

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“…Patients with end-stage chronic kidney disease (CKD) and maintenance haemodialysis treatment often present with an osteoarticular disease called renal osteodystrophy, which includes signs of secondary hyperparathyroidism, osteoporosis, osteosclerosis and osteomalacia [1][2][3][4][5][6]. Besides this, patients may complain of chronic pain and stiffness, with both large and small joints being affected symmetrically.…”

mentioning

confidence: 99%

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Paparella

Barbieri²,

Miscia³

et al. 2014

Anaesthesiol Intensive Ther

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Background: The aim of our study was to evaluate laboratory data behaviour in two dialysis populations, with and without dialysis-related arthropathy and pain. Methods: We produced an elaboration of more than 160,000 items of biochemical data of 25 dialysis-related arthropathy patients with chronic articular pain, and 25 patients asymptomatic for joint pain and arthropathy. The pain visual analogue scale (VAS) was employed for pain intensity determination. Results: The serum level of β-2 microglobulin was similar in the two groups of patients, while ferritin values were significantly higher in symptomatic patients. We excluded the possibility that the ferritin difference between the two groups was due to different iron storage and to an inflammatory profile. Furthermore, the pain VAS mean value was higher in patients who had higher ferritin and pain than in asymptomatic patients. Conclusion:It is important to underline that the higher value of ferritin in patients with chronic pain due to dialysis--related arthropathy could represent a new stimulus for a deeper investigation of this indicator, setting a periodic revelation of pain intensity.

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mentioning

confidence: 99%

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Paparella

Barbieri²,

Miscia³

et al. 2014

Anaesthesiol Intensive Ther

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“…7,8) Some clinical studies reported that the development of clinical DRA was decreased with the use of this advanced HD technique. 7,9) The use of highflux non-cellulose membrane with increased permeability enables the removal of moderately sized molecules (10,000-15,000 Da), including many of the inflammatory proteins, β-2 microglobulin, and lipoproteins, from the body. 10,11) In this case, due to the long-standing HD history, the patient had been on traditional HD until the full-blown destructive DRA developed.…”

Section: Discussionmentioning

confidence: 99%

Severe Destructive Tendinopathy in the Wrist Due to Dialysis-Related Amyloidosis

Kim

Choi²,

Park

2017

J Hand Surg Asian-Pac Vol

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Dialysis-related amyloidosis (DRA) is a specific subtype of amyloidosis with several clinical presentations. Herein we report a case of severe destructive tendinopathy around the wrist associated with long-standing hemodialysis (HD). A 63-year-old female patient who had been on regular HD for 23 years suffered from symptoms of pain and a palpable mass around the wrist. Magnetic resonance imaging showed an ill-defined soft tissue mass around the extensor tendons that partially invaded the wrist joint. We performed surgical excision and tenolysis for the mass. The operative finding revealed an ill-defined yellowish soft tissue mass extensively invading the extensor tendons and wrist joint. The tendon fibers were severely fibrillated and showed impending rupture due to the infiltrated mass. Histological examination showed DRA. Amyloidosis-induced tendinopathy should be considered when a patient on long-term HD complains of an unusual mass-like lesion in the extremity and/or nonspecific joint stiffness. Early surgical intervention improves patient’s disability and decreases the risk of spontaneous tendon rupture.

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“…Furthermore, the prevalence of CTS correlates with the duration of hemodialysis [5,8,14]. Although these patients are likely to have less favorable symptoms and functional status after carpal tunnel release, it is unclear if patients who have release for hemodialysis-associated CTS have differing long-term relief of symptoms compared with patients with idiopathic CTS.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of CTS correlates with the duration of hemodialysis [5,8], and CTS reportedly affects 32% to 50% of patients more than 10 years after the start of hemodialysis [8,14] and 80% over 30 years [14]. The reasons why patients receiving long-term hemodialysis have CTS develop are unclear.…”

Section: Introductionmentioning

confidence: 99%

Does Carpal Tunnel Release Provide Long-Term Relief in Patients with Hemodialysis-Associated Carpal Tunnel Syndrome?

Kang

Koh

Lee

et al. 2012

Clinical Orthopaedics &Amp; Related Research

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Background Carpal tunnel syndrome (CTS) is a common complication in patients receiving long-term hemodialysis. In the short-term however, these patients are less likely to have pain relief and restoration of function after carpal tunnel release. However, it is unclear whether patients who have release for hemodialysis-associated CTS have differing persisting relief of symptoms compared with patients with idiopathic CTS. Questions/purposes We therefore compared (1) the severity of pain and level of function in patients who had release for hemodialysis-associated CTS with scores of patients who had release for idiopathic CTS, and (2) the operation-related complications. Methods We retrospectively reviewed 36 patients with CTS who were receiving hemodialysis and 54 patients with idiopathic CTS. Control subjects were matched for age, gender, and symptom severity. We obtained Boston Carpal Tunnel Questionnaire (BCTQ) scores preoperatively and at each followup. The minimum followup was 24 months (mean, 44.3 months; range, 24-90 months), although all comparisons were made at 2 years.

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Characteristics of dialysis-related amyloidosis in patients on haemodialysis therapy for more than 30 years

Cited by 47 publications

References 15 publications

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?

Severe Destructive Tendinopathy in the Wrist Due to Dialysis-Related Amyloidosis

Does Carpal Tunnel Release Provide Long-Term Relief in Patients with Hemodialysis-Associated Carpal Tunnel Syndrome?

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