Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients

Yl, Choi; Ja, Kim; Kt, Jang; Ds, Kim; Ws, Kim; Jh, Lee; Jm, Yang; Es, Lee; Dy, Lee

doi:10.1111/j.1365-2133.2006.07456.x

Cited by 78 publications

(87 citation statements)

References 24 publications

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“…However, the skin may be the initial site of CMV involvement and may provide the first clue to systemic infection. A wide spectrum of cutaneous lesions associated with CMV infection has been reported, including morbilliform eruptions, purpura, vesiculobullous lesions, nodules, papular eruptions, verrucous lesions and ulcerations 9,10 , but to date no case of SJS has been related to this infectious agent. In our case a possible association between CMV and SJS is suggested by a temporal relationship.…”

Section: Discussionmentioning

confidence: 99%

“…necrosis factor agents, thalidomide, cyclosporine, cyclophosphamide, N-acetylcysteine and other modalities such as plasmaferesis, have been tried along with supportive measures, but with variable results 10 . In 1998, on the basis of the identification of the mechanism of keratinocytes apoptosis in SJS and TEN, a therapy approach based on the use of IVIg was proposed with uniformly favorable results 10,11 .…”

mentioning

confidence: 99%

“…In 1998, on the basis of the identification of the mechanism of keratinocytes apoptosis in SJS and TEN, a therapy approach based on the use of IVIg was proposed with uniformly favorable results 10,11 . Nevertheless, the literature about this specific treatment is still dominated by uncontrolled trials, retrospective studies, case series and anecdotal reports.…”

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confidence: 99%

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Stevens-Jonhson syndrome associated with cytomegalovirus infection in a child with ependymoma

Cruz

Mota²,

Baudrier³

et al. 2010

J Dermatol Case Rep

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Background: Stevens-Johnson syndrome is an uncommon, acute life-threatening disease characterized by extensive epidermal sloughing and mucositis. In childhood, as in adulthood, this condition is mostly related to drugs, in particular antibiotics. Only a few cases reported were firmly attributed to infectious agents, mainly Mycoplasma pneumonia but the causative role of infectious microorganisms seems particularly relevant in pediatric patients. The seriousness of this condition imposes a prompt recognition and the early withdrawal of the potential causative drugs or the institution of directed measures against infectious agents (depending on the suspected etiology), as well as a supportive and more specific therapy. Some treatments claim to halt the progression of skin detachment, but remain of unproven benefit due to the lack of prospective, well controlled, randomized clinical trials.Main Observations: We report a case of a 2-year-old boy admitted in our hospital for the treatment of an ependymoma of the posterior fossa, who developed a Stevens-Johnson syndrome associated most probably with a cytomegalovirus infection. He was successfully treated with high dose intravenous immunoglobulin and gancyclovir.Conclusion: To the best of our knowledge, this is the first case of SJS associated with CMV infection.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Stevens-Jonhson syndrome associated with cytomegalovirus infection in a child with ependymoma

Cruz

Mota²,

Baudrier³

et al. 2010

J Dermatol Case Rep

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“…but to date no case of SJS has been related to this infectious agent [18]. However, a relationship between viral infections and the simultaneous or subsequent development of drug-induced hypersensitivity has been observed in a number of clinical situations, while the full cascade of events leading from viral infections to the development of this exfoliative situation in human's remains poorly understood [19,20]. In this study we have tried to establish a possible association between HCMV and SJS/TEN suggested possibly by a temporal clinical relationship.…”

Section: Immunological Parameters In Patients With Hcmv Associated Sjmentioning

confidence: 99%

A Comparative Insight into the Incidence of Steven Johnson Syndrome/ Toxic Epidermal Necrolyis among the Immunocompromized Patient Populace of Eastern India with a Distinctive Emphasis on the Possible Association of Human Cytomegalovirus

Chatterjee¹,

Thakur²,

Ansari³

et al. 2017

J AIDS Clin Res

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“…As manifestações cutâneas são raras e, quando presentes, têm um polimorfismo lesional caracterizado por vesículas, nódulos, placas verrucosas ou ulcerações orais, perianais e genitais. 1,3,4 O tratamento e a profilaxia da infeção por CMV em imunodeprimidos incluem ganciclovir (iv), valganciclovir (po), foscarnet (iv) ou cidofovir (iv). 1,5,6 Apresentamos o caso de uma doente com síndrome de imunodeficiência adquirida (SIDA), gravemente imunodeprimida, com ulcerações extensas provocadas por CMV.…”

Section: Introductionunclassified

Infeção Cutânea por Citomegalovírus em Doente com Infecção VIH/SIDA

Banquimane

Gudo

Cunha

et al. 2016

SPDV

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RESUMO -A infecção por citomegalovírus tem distribuição mundial com alta prevalência nos países subdesenvolvidos, onde atinge quase 100% da população. As manifestações cutâneas são raras. A apresentação inespecífica das mesmas pode contribuir para o subdiagnóstico da doença. Relatamos o caso clínico de uma doente de 24 anos, gravemente imunodeprimida, com ulcerações na pele com quatro meses de evolução, e diagnóstico de infecção por vírus de imunodeficiência humana tipo 1 dois meses após o início das lesões. Na terceira semana de internamento desenvolveu uma retinite aguda por citomegalovírus e, embora tenha iniciado tratamento antirretrovírico e depois ganciclovir acabou por falecer após três meses por pericardite aguda. PALAVRAS-CHAVE -Dermatopatias Virais; Infecções por Citomegalovirus; Infecções por VIH; Infecções Oportunistas Relacionadas com a SIDA; Moçambique. Cutaneous infection with cytomegalovirus in patients with HIV / AIDS infection ABSTRACT -Infection by cytomegalovirus has worldwide distribution with high prevalence in developing countries, where it reaches almost 100% of the population. Cutaneous manifestations are rare. Moreover, unspecific presentation of dermatological lesions may contribute to subdiagnosis of the disease. We report a case of a 24 years-old female patient, severely immunocompromised, with ulcerations on the skin with 4 months of evolution, diagnosed with human immunodeficiency virus type 1 infection two months after the onset of lesions. In the third week of hospitalization she developed an acute cytomegalovirus retinitis, and despite initiation of anti-retroviral and anti-cytomegalovirus treatment initiation, she died after three months with an acute pericarditis. KEY-WORDS -AIDS-Related Opportunistic Infections; Cytomegalovirus Infections; HIV Infections; Mozambique; Skin Diseases, Viral.INTRODUÇÃO O citomegalovírus (CMV) é um vírus pertencente à famí-lia Herpesviradae, cuja patogénese, à semelhança de outros herpesvírus, obedece à sequência primo-infeção, latência e reactivação.1 A prevalência da infecção pelo CMV é variá-vel: cerca de 40% nos países desenvolvidos e quase 100% nos subdesenvolvidos.2 Pensa-se que a elevada prevalência nestes últimos países se deva, entre outros fatores, a más condições de higiene relacionados com grandes aglomerados populacionais onde coabitam, em pequenos espaços, numerosos adultos e crianças. 1A principal forma de transmissão do CMV é o contacto sexual embora, para além do esperma e secreções cervicovaginais, sejam também veículos de transmissão do vírus a Correspondência:

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Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients

Cited by 78 publications

References 24 publications

Stevens-Jonhson syndrome associated with cytomegalovirus infection in a child with ependymoma

Stevens-Jonhson syndrome associated with cytomegalovirus infection in a child with ependymoma

A Comparative Insight into the Incidence of Steven Johnson Syndrome/ Toxic Epidermal Necrolyis among the Immunocompromized Patient Populace of Eastern India with a Distinctive Emphasis on the Possible Association of Human Cytomegalovirus

Infeção Cutânea por Citomegalovírus em Doente com Infecção VIH/SIDA

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