Characteristics of Cold Atmospheric Plasma Jet when Excited by Sinusoidal and Positive Pulse Voltages for Medical Applications

Abstract

Low-temperature plasma jets at atmospheric pressure generated by sinusoidal and positive pulsed voltages interact differently with the treated surface. In the experiment and in numerical simulations, we compare the operating modes of helium plasma jets for these types of operating voltages. The discharge current on the treated surface over time and the surface heating are studied for different discharge parameters acceptable for anticancer therapy. The intensity of the emission spectrum is analyzed to improve the effectiveness of the plasma jet. Surface heating is controlled in order to meet the safety conditions of plasma exposure to biological objects. For the case of pulsed voltage the effect of voltage pulse duration on the intensity of plasma-surface interaction is discussed. The results on cancer cells A549 and MCF-7 demonstrate the high efficiency of the cold plasma jet generated at found optimal modes.

Pulsed voltage cold atmospheric plasma jet and gold nanoparticles enhance cytotoxic anticancer effect

“…In our earlier study of CAPJ regimes we demonstrated that the intensity of CAPJ interaction with the target is a nonmonotonic function of the voltage amplitude and frequency [6,7,31]. The aim of this study is to find a CAPJ regime with optimal characteristics: (1) streamers touch the target at each voltage cycle, (2) the current amplitude near the target I has the maximum value and (3) the temperature in the contact zone is less than 42 • C. We expected that the maximal cytotoxic effect of CAPJ treatment depends on a regularity of streamer propagation to the target and increases with an increase of the discharge current on the treated surface.…”

“…The bio experiments confirmed that the sin CAPJ with U = 3.3-3.5 kV and f U = 50 kHz is the most effective for suppression of cancer cells growth. Figure 5 from our paper [7] shows the measured current near the target, the applied voltage, and the viability of A549 cells after exposure to the sin CAPJ, at U = 3.5 kV, f U = 13 kHz and f U = 50 kHz. It should be noted that this effective sin CAPJ mode is difficult to maintain in the experiment.…”

“…Streamers in the high-voltage CAPJ not only generate more radicals in the surrounding air but also deliver a large electric field to the target, which temporarily changes the permeability of the cancer cell membrane [5]. The values of temperature and voltage can be decoupled when the CAPJ is ignited by a positive-pulsed (PP) voltage with a trapezoidal pulse shape [6][7][8]. The thermal effect at the high voltage can be reduced by changing the duration of the voltage pulse.…”

Effect of the Cold Atmospheric Plasma Technology for Treatment the Cancer Diseases in the Human: A literature Review

“…The plasma jet is defined by discharge propagation along that tube and subsequently in free space and contact with surfaces. A review paper (Corbella, et al 2023) and another review article (Schweigert, et al 2023) have been written to provide the current state-of-the-art in creating CAPJs.…”