Characteristics of circadian rhythm-related genes and establishment of a prognostic scoring system for lung adenocarcinoma with experimental verification: a bioinformatics analysis

Zhang, Fengbin; Zhang, Qi; Jiang, Taie; Fan, Xiaoyu; Wang, Wenmiao; Liu, Lehan; Liu, Kun

doi:10.21037/jtd-22-1112

Cited by 3 publications

(2 citation statements)

References 25 publications

(38 reference statements)

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“…In fact, the circadian clock informs about the optimal timing and dosing of the drug, which is novel when compared to traditional pharmacotherapy. In addition, it has been found that a circadian rhythm-related genes-based scoring system can help to assess the prognosis of patients with lung adenocarcinoma ( 40 ). Another critical role of the circadian clock is to coordinate functions of the immune system ( 41 - 47 ).…”

Section: Genetic Underpinnings Of Circadian Rhythmsmentioning

confidence: 99%

Enhancing circadian rhythms—the circadian MEGA bundle as novel approach to treat critical illness

Prin,

Bertazzo,

Walker

et al. 2023

Ann Transl Med

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Circadian rhythms are essential to physiological homeostasis, but often disrupted in the intensive care unit (ICU) due to the absence of natural zeitgebers and exposure to treatments which affect circadian regulators. This is increasingly recognized as a contributor to morbidity and mortality across a variety of medical conditions including critical illness. Maintenance of circadian rhythms is particularly relevant to critically ill patients, who are restricted not only to the ICU environment but often bed bound. Circadian rhythms have been evaluated in several ICU studies, but effective therapies to maintain, restore, or amplify circadian rhythms have not been fully established yet. Circadian entrainment and circadian amplitude enhancement are integral to patients’ overall health and well-being, and likely even more important during response to and recovery from critical illness. In fact, studies have shown that enhancing the amplitude of circadian cycles has significant beneficial effects on health and wellbeing. In this review, we discuss up-to-date literature on novel circadian mechanism that could not only restore but enhance circadian rhythms in critical illness by using a MEGA bundle consisting of intense light therapy each morning, cyclic nutrition support, timed physical therapy, nighttime melatonin administration, morning administration of circadian rhythm amplitude enhancers, cyclic temperature control and a nocturnal sleep hygiene bundle.

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Section: Genetic Underpinnings Of Circadian Rhythmsmentioning

confidence: 99%

Enhancing circadian rhythms—the circadian MEGA bundle as novel approach to treat critical illness

Prin,

Bertazzo,

Walker

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Circadian biological rhythm misalignment is closely associated with an increased risk of various diseases, such as neurological diseases, sleep disorders, metabolic syndrome, epigenetic regulation, cardiovascular diseases, immune diseases, and cancer ( 11 , 12 ). Circadian rhythm-related genes help to guide personalized cancer immunotherapy strategies ( 13 ). Moreover, melatonin plays a critical role in pregnancy and fetal and postnatal development.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the postoperative in-hospital versus at-home recovery quality and circadian rhythm status in preschool kids after adenotonsillectomy: a cohort and observational study

Qiu¹,

Xu²,

Tan³

et al. 2023

Transl Pediatr

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Background: At present, minimally invasive surgery is often used in paediatric patients as a day surgery to promote rapid post-operative recovery. Obstructive Sleep Apnea Syndrome (OSAS) Patients recovery in the hospital or at home after surgery may differ in terms of recovery quality and circadian rhythm status because of sleep disruption; however, this remains unknown. Pediatric patients usually unable to explain their feelings effectively, and objective indicators to measure recovery situation in different environments are promising.This study was conducted to compare the impact of in-hospital and at-home postoperative recovery quality (primary outcome) and circadian rhythm (as measured via the salivary melatonin level) (secondary outcome) in preschool-age patients.Methods: This was a cohort, non-randomized and exploratory observational study. A total of 61 children aged 4 to 6 years who were scheduled to receive adenotonsillectomy were recruited and assigned to recover either in the hospital (Hospital group) or at home (Home group) after surgery. There were no differences in the patient characteristics and perioperative variables between the Hospital and Home groups at baseline. They received the treatment and anesthesia in the same way. The patients' preoperative and up to 28 days post-surgery OSA-18 questionnaires were harvested. Moreover, their pre-and post-surgery salivary melatonin concentrations, body temperature, three-night postoperative sleep diaries, pain scales, emergence agitation, and other adverse effects were recorded.Results: There were no significant differences in the postoperative recovery quality, as assessed by the OSA-18 questionnaire, body temperature, sleep quality, pain scales, and other adverse events (such as respiratory depression, sinus bradycardia, sinus tachycardia, hypertension, hypotension, nausea, and vomiting) between the two groups. The preoperative morning saliva melatonin secretion was decreased in both groups on the first postoperative morning (P<0.05), while a significantly greater decrease was found in the Home group on postoperative day 1 (P<0.05) and day 2 (P<0.05). Conclusions:The postoperative recovery quality of preschool kids in the hospital is as good as at home based on OSA-18 evaluation scale. However, the clinical importance of the significant decrease in morning saliva melatonin levels with at-home postoperative recovery remains unknown and warrants further study.

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Multi-omics and single-cell sequencing analyses reveal the potential significance of circadian pathways in cancer therapy

Lai,

Xiang,

Long

et al. 2024

Expert Review of Molecular Diagnostics

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Characteristics of circadian rhythm-related genes and establishment of a prognostic scoring system for lung adenocarcinoma with experimental verification: a bioinformatics analysis

Cited by 3 publications

References 25 publications

Enhancing circadian rhythms—the circadian MEGA bundle as novel approach to treat critical illness

Enhancing circadian rhythms—the circadian MEGA bundle as novel approach to treat critical illness

Comparison of the postoperative in-hospital versus at-home recovery quality and circadian rhythm status in preschool kids after adenotonsillectomy: a cohort and observational study

Multi-omics and single-cell sequencing analyses reveal the potential significance of circadian pathways in cancer therapy

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