Characteristics of Cardiac Allograft Vasculopathy Induced by Immunomodulation in the Miniature Swine

Amano, Jun; Akashima, Tomohiro; Terasaki, Takamitsu; Wada, Yuko; Ito-Amano, Midori; Suzuki, Jun–ichi; Isobe, Mitsuaki

doi:10.5761/atcs.oa.13-00311

Cited by 11 publications

(13 citation statements)

References 22 publications

(29 reference statements)

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“…The first description of five left ancient ventricular polypus specimens was summarized by T. W. King in 1845 [22]. CM is the most common cardiac tumor in adults and accounts for approximately 50-75% and > 50% of benign and primary cardiac neoplasms, respectively [23][24][25][26][27][28]. Left atrial CM is twice most common in women, compared to men [29].…”

Section: Introductionmentioning

confidence: 99%

Developing a novel positronium biomarker for cardiac myxoma imaging

et al. 2023

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Purpose Cardiac myxoma (CM), the most common cardiac tumor in adults, accounts for 50–75% of benign cardiac tumors. The diagnosis of CM is often elusive, especially in young stroke survivors and transthoracic echocardiography (TTE) is the initial technique for the differential diagnostics of CM. Less invasive cardiac computed tomography (CT) and magnetic resonance imaging (MRI) are not available for the majority of cardiac patients. Here, a robust imaging approach, ortho-Positronium (o-Ps) imaging, is presented to determine cardiac myxoma extracted from patients undergoing urgent cardiac surgery due to unexpected atrial masses. We aimed to assess if the o-Ps atom, produced copiously in intramolecular voids during the PET imaging, serves as a biomarker for CM diagnosing. Methods Six perioperative CM and normal (adipose) tissue samples from patients, with primary diagnosis confirmed by the histopathology examination, were examined using positron annihilation lifetime spectroscopy (PALS) and micro-CT. Additionally, cell cultures and confocal microscopy techniques were used to picture cell morphology and origin. Results We observed significant shortening in the mean o-Ps lifetime in tumor with compare to normal tissues: an average value of 1.92(02) ns and 2.72(05) ns for CM and the adipose tissue, respectively. Microscopic differences between tumor samples, confirmed in histopathology examination and micro-CT, did not influenced the major positronium imaging results. Conclusions Our findings, combined with o-Ps lifetime analysis, revealed the novel emerging positronium imaging marker (o-PS) for cardiovascular imaging. This method opens the new perspective to facilitate the quantitative in vivo assessment of intracardiac masses on a molecular (nanoscale) level.

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Section: Introductionmentioning

confidence: 99%

Developing a novel positronium biomarker for cardiac myxoma imaging

et al. 2023

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“…Of these, myxomas are the most common primary tumors. Originating from primitive connective tissues cells, myxomas are benign masses composed of cells within a mucopolysaccharide stroma . They usually occur sporadically but can be inherited and are more frequently found in middle-aged adults, with a greater predilection for women .…”

Section: Discussionmentioning

confidence: 99%

A Middle-aged Man With Sharp Chest Pain

Gaba

Luber

2021

JAMA Cardiol

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“…Until now, various minipig models have been successfully used to reproduce cardiovascular human diseases and have helped our understanding of the mechanisms and pathophysiology of the diseases. As examples, the coronary atherosclerosis model has been studied in the minipig (Swindle et al 2012;Getz and Reardon 2012;Hamamdzic and Wilensky 2013), and in the cardiac allograft vasculopathy minipig model mimicking human heart transplantation, cyclosporine A was shown to induce proliferation and migration of smooth muscle cells from the media to the intima, leading to intimal thickening (Amano et al 2015). In humans, arteritis or polyarteritis includes a range of different forms or entities, which has been classified with variable success according to vessel diameter, role of immune complexes, presence of specific autoantibodies, granuloma formation, organ specificity, and even population demographics (Mitchell 2015).…”

Section: (E) Human Relevancementioning

confidence: 99%

Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review

et al. 2018

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Arteritis/polyarteritis occurs spontaneously in many species used in preclinical toxicology studies. In Göttingen minipigs, arteritis/polyarteritis is an occasionally observed background change. In the minipig, this finding differs in frequency and nature from age-related polyarteritis nodosa in rats or monkeys, and Beagle pain syndrome in dogs. In minipigs, it can be present in a single small- or medium-sized artery of an organ or a few organs and is most commonly recorded in the cardiac and extracardiac blood vessels, vagina, oviduct, rectum, epididymis, spinal cord, pancreas, urinary bladder, kidneys, and stomach. The etiology is unknown although it has been considered in minipigs as well as in rats, dogs, and monkeys to be possibly immune mediated. This background change is important with respect to its nature and distribution in the minipig in order to distinguish it from drug-induced vascular changes, which might occur in similar locations and have similar morphologic features. This review summarizes the morphology, incidence, and predilection sites of arteritis as a spontaneously occurring background change and as a drug-induced vasculopathy in the minipig, and also describes the main aspects to consider when evaluating vascular changes in Göttingen minipig toxicity studies and their human relevance.

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Characteristics of Cardiac Allograft Vasculopathy Induced by Immunomodulation in the Miniature Swine

Cited by 11 publications

References 22 publications

Developing a novel positronium biomarker for cardiac myxoma imaging

Developing a novel positronium biomarker for cardiac myxoma imaging

A Middle-aged Man With Sharp Chest Pain

Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review

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