Characteristics of C4- and C8-bonded vinyl alcohol copolymer gels for reversed-phase high-performance liquid chromatography

Ohtani, Tomoko; Tamura, Yuma; Kasai, Masao; Uchida, Taketeru; Yanagihara, Yuzo; Noguchi, Kohji

doi:10.1016/s0021-9673(01)89311-0

Cited by 11 publications

(2 citation statements)

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“…Their hydrophobic structure confers to them a retention potential higher than the one of bonded silicas for sample preparation or the analysis of analytes such as triazines or other aqueous pollutants [213]. Difficult separations on C18 bonded silicas were carried out at pH 11 without peak tailing [224,225]. A polyvinyl pyridine-polystyrene polymer has also been manufactured for the analysis of basic solutes [218,219].…”

Section: Polymeric Supportsmentioning

confidence: 99%

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Silica and other materials as supports in liquid chromatography. Chromatographic tests and their importance for evaluating these supports. Part I

et al. 2001

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Reversed-phase liquid chromatography (RP-HPLC) has become a powerful and widely employed technique in the separation and analysis of a great variety of compounds with different functionalities. The most common type of stationary phase for RP-HPLC consists of nonpolar, hydrophobic organic species (e.g., octyl, octadecyl) attached by siloxane bonds to the surface of a silica support. In the first part of this article, a description of the many beneficial properties that make porous silica the most employed support in RP-HPLC will be presented, starting from the synthesis of silica. It is noteworthy that the chromatographic properties of the final column are strictly correlated to the preparation type. A silica surface possesses a number of attractive properties, but also some drawbacks. Unreacted or residual silanols interact with basic compounds and can induced peak tailing, which means a loss in chromatographic performance. This problem has lead many manufactures to produce stationary phases with reduced silanol activity which improve dramatically the peak shape of basic compounds. In the second part of this review, different approaches are proposed to obtain less reactive stationary phases

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Section: Polymeric Supportsmentioning

confidence: 99%

“…The polymer layer can either be phy-sically adsorbed or chemically bonded. Various polymers have been used giving rise to different stationary phases [225,230,236,237]. Various polymers have been used giving rise to different stationary phases [225,230,236,237].…”

Section: Polymeric Supportsmentioning

confidence: 99%