Characteristics of Breast Cancer Metastasizing to Bone in a Mediterranean Population

Bannoura, Sami; Nahouli, Hasan; Noubani, Aya; Flaifel, Abdallah; Khalifeh, Ibrahim

doi:10.7759/cureus.11679

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…3.4. There Are No Significant Differences in Macro-or Microscopic Changes to the Hind Limb in Mice with ER-Expressing or TN BC Bone metastases from BC are a serious complication and patients with ER+ BC are at an increased risk for developing bone metastases which can lead to osteoblastic, osteolytic, or mixed reactions with osteolytic being the most common [15]. Furthermore, with primary breast cancer, the bone niche is modified prior to metastases arriving in the tissue, including increased vasculature growth and hematopoietic stem cells [7,[16][17][18][19][20].…”

Section: Lungmentioning

confidence: 99%

A Novel Metastatic Estrogen Receptor-Expressing Breast Cancer Model with Antiestrogen Responsiveness

Langsten,

Shi,

Wilson

et al. 2023

Cancers

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Most women diagnosed with breast cancer (BC) have estrogen receptor alpha-positive (ER+) disease. The current mouse models of ER+ BC often rely on exogenous estrogen to encourage metastasis, which modifies the immune system and the function of some tissues like bone. Other studies use genetically modified or immunocompromised mouse strains, which do not accurately replicate the clinical disease. To create a model of antiestrogen responsive BC with spontaneous metastasis, we developed a mouse model of 4T1.2 triple-negative (TN) breast cancer with virally transduced ER expression that metastasizes spontaneously without exogenous estrogen stimulation and is responsive to antiestrogen drugs. Our mouse model exhibited upregulated ER-responsive genes and multi-organ metastasis without exogenous estrogen administration. Additionally, we developed a second TN BC cell line, E0771/bone, to express ER, and while it expressed ER-responsive genes, it lacked spontaneous metastasis to clinically important tissues. Following antiestrogen treatment (tamoxifen, ICI 182,780, or vehicle control), 4T1.2- and E0771/bone-derived tumor volumes and weights were significantly decreased, exemplifying antiestrogen responsivity in both cell lines. This 4T1.2 tumor model, which expresses the estrogen receptor, metastasizes spontaneously, and responds to antiestrogen treatment, will allow for further investigation into the biology and potential treatment of metastasis.

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Section: Lungmentioning

confidence: 99%

A Novel Metastatic Estrogen Receptor-Expressing Breast Cancer Model with Antiestrogen Responsiveness

Langsten,

Shi,

Wilson

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

Characteristics of Breast Cancer Metastasizing to Bone in a Mediterranean Population

Abstract: Bannoura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 1 publication

References 28 publications

A Novel Metastatic Estrogen Receptor-Expressing Breast Cancer Model with Antiestrogen Responsiveness

A Novel Metastatic Estrogen Receptor-Expressing Breast Cancer Model with Antiestrogen Responsiveness

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