Characteristics of brachial–ankle pulse wave velocity in Japanese children

Niboshi, Ayumi; Hamaoka, Kenji; Sakata, Koichi; Inoue, Fumio

doi:10.1007/s00431-006-0135-y

Cited by 77 publications

(64 citation statements)

References 21 publications

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“…In concordance with the results of earlier studies, 17,18 the baPWV of adolescents in this study was influenced by age and gender. However, a multivariate regression analysis revealed that MAP, atherogenic index, HOMA-IR and SBP were independently associated with baPWV after statistically adjusted for the impact of age and gender.…”

Section: Discussionsupporting

confidence: 93%

“…For instance, an earlier study using children of wide age range could not show the correlation of baPWV with obesity index. 17 We selected the adolescents, aged 15-17 years, as study population to clarify the relationship of obesity and metabolic risk variables with baPWV by eliminating the impact of age-and development-related changes as much as possible. The baPWV is obtained simply and non-invasively; therefore, it can be applied for the screening of early arterial wall changes in adolescent population.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Therefore, baPWV measurement may be suitable for the assessment of arterial wall properties in adolescents, although few studies have been conducted in this generation. [17][18][19] The purpose of this study was to determine whether baPWV is affected by obesity and its associated metabolic abnormalities and whether baPWV is applicable to the investigation of the early progression of arterial stiffness in healthy adolescents.…”

Section: Introductionmentioning

confidence: 99%

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The influence of obesity and metabolic risk variables on brachial-ankle pulse wave velocity in healthy adolescents

et al. 2008

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Measurement of brachial-ankle pulse wave velocity (baPWV) is recognized as a simple and practical method for assessing arterial stiffness. We determined whether the baPWV of adolescents is affected by obesity and its associated metabolic risk variables. A cross-sectional sample of 754 apparently healthy adolescents (383 men and 371 women), aged 15-17 years, was recruited for this study. baPWV was measured by a simple automatic oscillometric technique. Adiposity measures, blood pressure, serum lipoproteins, fasting glucose and insulin were evaluated. The baPWV of the adolescents was significantly higher in men than in women and increased with age in both genders. After being statistically adjusted for age and gender, baPWV was significantly correlated with body mass index, percent body fat, waistto-height ratio, systolic and diastolic blood pressures, mean arterial pressure, triglycerides, high-density lipoprotein cholesterol (HDL-C), atherogenic index, glucose, insulin, and homoeostasis model assessment of insulin resistance (HOMA-IR). In the multivariate regression analysis, mean arterial pressure, atherogenic index, HOMA-IR, systolic blood pressure and age were found to be significant determinants of baPWV (Po0.001). An increasing number of clustered risk variables, including high values (4gender-specific top quartiles) of waist-toheight ratio, mean arterial pressure, atherogenic index and HOMA-IR showed a graded association with baPWV (Po0.001 for trend). These results suggest that obesity and its associated metabolic abnormalities are important factors in the increased baPWV of adolescents and that baPWV may be useful in investigating early arterial wall changes in this population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of obesity and metabolic risk variables on brachial-ankle pulse wave velocity in healthy adolescents

et al. 2008

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“…37,38 Several investigators have demonstrated that baPWV showed a significant correlation with MAP in young adults 18,36 and with SBP and DBP in children. 35,39 In the Bogalusa Heart Study, Li et al 34 reported that childhood blood pressure was a predictor of arterial stiffness in adulthood. AP level is thought to contribute considerably to arterial stiffness.…”

Section: Macroscopic and Microscopic Findings Of The Aortamentioning

confidence: 99%

To what extent does aortic pulse wave velocity estimate early atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits?

et al. 2011

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Pulse wave velocity (PWV), an index of arterial stiffness, is dependent not only on structural alterations in arterial wall but also on distending pressure, which could be related to wall distensibility. We investigated the efficacy of aortic PWV (AoPWV) for detecting early to moderate atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Pressure waves were recorded at the ascending, and proximal and distal abdominal aortas in 13 male normal and KHC rabbits aged 12 months under pentobarbital anesthesia when angiotensin II or sodium nitroprusside was infused intravenously. AoPWV was compared between the two rabbit groups at different mean arterial pressure (MAP) levels. Vascular diameter (D m ) was measured using an intravascular ultrasound imaging system in the proximal thoracic and proximal abdominal aortas to determine pressure-strain elastic modulus (E p ). AoPWV was correlated to MAP in the two rabbit groups (Po0.001). AoPWV was slightly but significantly greater (o0.5 m s À1 ) in the KHC rabbit group than in the normal rabbit group at MAP level 480 mm Hg (Po0.01). The value of h/D m (h, wall thickness) was significantly high in the KHC rabbit group at any MAP level (Po0.001) in these aortic regions. There was no significant difference in E p and D m between the two rabbit groups at any MAP level. AoPWV showed only a slight but significant increase in the young KHC rabbits at different MAP levels, which was mainly due to the increased h/D m . AoPWV could underestimate aortic stiffness due to early to moderate atherosclerosis if AoPWV was adjusted for arterial pressure level.

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“…17) Automated devices are expected to be fast, simple, and accurate vascular screening tools. 9,18,19) We had lectures and practicum for our medical students regarding these instruments. The students measured ABI or TBI among themselves using form PWV/ABI ® .…”

Section: Introductionmentioning

confidence: 99%

Ankle-Brachial Index, Toe-Brachial Index, and Pulse Volume Recording in Healthy Young Adults

Watanabe

Hara

Yunoki

et al. 2015

Annals of Vascular Diseases

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Objective: To clarify the characteristics of ankle-brachial index (ABI), toe-brachial index (TBI), and pulse volume recording (PVR) of the ankle with brachial-ankle pulse wave velocity (baPWV) in healthy young adults. Material and Methods: We analyzed ABI, TBI, baPWV, and PVR in the ankle of healthy adults aged 20 to 25 years (median, 20 years) using an automatic oscillometric device between 2002 and 2013. The ABI, baPWV, and PVR in 1282 legs of 641 subjects (301 men and 340 women) and the TBI in 474 toes of 237 subjects (117 men and 120 women) were evaluated. Results:The measured values showed no bilateral differences. ABI and baPWV were higher in men than in women, but TBI was similar in both sexes. ABI <1.0 was observed in 18.1% of the legs in men and in 25.6% in women. TBI <0.7 was observed in 16.2% of the toes in men and 19.1% in women. For ankle PVR, the % mean arterial pressure was higher in women than in men. The upstroke time was <180 ms in most subjects. Conclusions: For young people, ABI <1.0 or TBI <0.7 may not always indicate vascular abnormalities. When evaluating circulatory indexes, age and sex should be considered.Keywords: ABI, TBI, baPWV, PVR, healthy young adults indications of ABI. The cut-off value of ABI for detecting PAD has been confirmed as 0.9 with high sensitivity and specificity. 2) Moreover, ABI is a strong predictor of cardiovascular events: the normal ABI range was revised as 1.00 to 1.40, because patients with ABI ranging from 0.91 to 0.99 have been shown to be at the borderline of cardiovascular risk. 2) On the other hand, TBI measurements are more cumbersome and are limited to special institutions (e.g., vascular laboratories) using different techniques including laser Doppler flowmetry, photoplethysmography, oscillometric plethysmography, and mercury strain gauge plethysmography. Thus, basic data on a uniform technique for a large population remain limited. Although the cut-off value of TBI for detecting PAD is set at 0.6 or 0.7, there has been no global consensus. 1,[3][4][5] Although the normal standard ranges of ABI and TBI are based on data obtained mostly from middle and senior adults, [3][4][5][6] young patients with lower limb complaints such as coldness, pain, or claudication are also primarily examined by ABI and TBI measurements because PAD including Buerger disease, Raynaud disease, Takayasu arteritis, and even arteriosclerotic diseases can occur in young patients, as the prevalence of PAD is estimated to be 1.2% to 4% of people in their late 20s. 7) However, they occasionally show ABI <1.0 or TBI <0.7 despite their normal physical findings, making the diagnosis confusing.The gold standard method for ABI measurement has been the Doppler method since the 1980s, 2) but on the other hand, automated oscillometric sphygmomanometers have come into use recently. Moreover, full-automated ABI/TBI measuring devices have been developed since the late 1990s. 8,9) We have used the automated ABI/TBI measuring devices in our clinical work. The form PWV/ABI ® (Colin Co., Aichi, Jap...

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Characteristics of brachial–ankle pulse wave velocity in Japanese children

Abstract: On the basis of these results, we suggest that baPWV in children is largely influenced by age and gender, and that baPWV gradually increased with age in both genders.

Cited by 77 publications

References 21 publications

The influence of obesity and metabolic risk variables on brachial-ankle pulse wave velocity in healthy adolescents

The influence of obesity and metabolic risk variables on brachial-ankle pulse wave velocity in healthy adolescents

To what extent does aortic pulse wave velocity estimate early atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits?

Ankle-Brachial Index, Toe-Brachial Index, and Pulse Volume Recording in Healthy Young Adults

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