Characteristics of bone metabolism parameters in urban citizens

Abstract

Aim. To reveal the features of age-dependent changes of bone tissue in urban citizens. 
 Methods. The study of bone metabolism parameters was performed on 629 healthy subjects of middle, elderly and senile age living in Vladivostok for longer than 10 years (55 males and 573 females). Concentration of C-terminal telopeptide of type II collagen, osteocalcin, calcitonin, parathyroid hormone, 1,25(OH)2-vitamin D, and bone isoenzyme of alkaline phosphotase were measured by ELISA. Concentration of C-terminal telopeptide of type I collagen was measured in urine. 
 Results. Biochemical markers of bone metabolism in older age groups are different from the parameters of middle age. In the second period of middle age statistically significant decrease of C-terminal telopeptides level (z=2.88, p