Characteristics of Blood Biomarkers in the Prospective Follow-Up of Patients With Cardiovascular Pathology in Combination With Type 2 Diabetes Mellitus After Covid-19 Associated Pneumonia

Abstract

The study of the characteristics and dynamics of laboratory biomarkers in patients with cardiovascular diseases (CVD) with type 2 diabetes mellitus who underwent COVID-19-associated pneumonia is of great clinical importance for preventing the risk of adverse events. IN the study we used data from 65 patients in the present work. Patients were divided into 2 groups: group 1 included patients with CVD: arterial hypertension (AH) in combination with coronary artery disease (CAD) without DM2 (n=45), group 2 included patients with CVD and DM2 (n=20). Patients were examined at baseline in the infectious disease hospital and 3 months after discharge. During laboratory examination of blood biosamples we evaluated parameters of general blood test; biochemical and immunologicai parameters; elastic properties of the vascular wall. The analyzed leukocyte parameters and their index coefficients - increase in NLR ratio (neutrophils/lymphocytes) and decrease in LYM/CRP ratio (lymphocytes/CRP) were more significantly changed in DM2 group. Patients in both groups had a significant excess of baseline max CRP concentrations with decrease in parameters after 3 months, but with persistent excess values in group 2. Three months after discharge patients with DM2 had levels of hs-CRP, IL-1β and TNFa and NT-proBNP, that exceeded both the reference values and those in group 1, which reflected the presence of more pronounced vascular inflammatory potential for possible adverse events in this group of patients in post-COVID period. The method of multiple regression showed that DM2 is an independent risk factor for increased stiffness of the vascular wall. Thus, dynamic control of laboratory parameters has prognostic value in assessing the nature of the course of COVID-19 associated pneumonia in patients with CVD and DM2 developing an algorithm for personalized monitoring of patients in the post-COVID period with the aim of timely prevention of unwanted vascular complications.

Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study

“… 46 , 47 NLR, MLR, PLR and SII have also been proposed as biomarkers to assess the severity, morbidity, mortality and prognosis of psychiatric and non-psychiatric illnesses. 48 Likewise, it has been reported that NLR and other inflammatory markers decrease after a few weeks compared to acute COVID-19 levels 49 , 50 Although SII, NLR and PLR are suggested to predict the risk of severe COVID-19 and mortality, the inflammatory indices could decrease over time in COVID-19 survivors. 30 , 49 , 51 According to this, individuals with post-COVID condition have shown a relationship between the severity of deterioration and age, where younger patients show impairment in some cognitive domain more frequently than older ones.…”

Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model

“…SARS-CoV-2 infection predisposes individuals to hypercoagulation and thrombotic complications, often leading to poor prognosis and necessitating intensive care regardless of the presence of diabetes ( Abdi et al, 2022 ; Abou-Ismail et al, 2020 ; Abrignani et al, 2022 ; Desdiani, 2022 ). In addition, COVID-19 patients with pre-existing diabetes are more likely to develop severe or critical thromboembolic complications relative to those without diabetes ( Petelina et al, 2022 ; Tang et al, 2020 ). However, the relationship between diabetes and SARS-CoV-2 infection-related symptoms, underlying pathogenic mechanisms in COVID-19 patients with diabetes, and effective treatment strategies have not been sufficiently studied.…”