Characteristics of bipolar disorder patients treated with immediate- and extended-release quetiapine in a real clinical setting: a longitudinal, cohort study of 1761 patients

Abstract

Differential use of quetiapine XR and IR in bipolar disorder patients with different and important characteristics was demonstrated. Patients who were switched to quetiapine XR had a higher psychiatric disease burden, were younger and had a higher degree of employment. These differences demonstrate the heterogeneity among bipolar disorder patients and indicate the need in clinical practice for individualized treatment to reduce the risk for both patient and society related losses.

Sex-Specific Associations Between Bipolar Disorder Pharmacological Maintenance Therapies and Inpatient Rehospitalizations: A 9-Year Swedish National Registry Study

“…Quetiapine also exists in either immediate- or extended- release formulations. In Sweden, the latter is more often prescribed to those with a higher disease burden or psychiatric comorbidity ( 48 ). Therefore, those treated with the extended release formulation could represent a subgroup that is more likely to require inpatient care.…”

Experience of Extending Antipsychotic Aid to Women With Epilepsy Complicated by Psychotic Disorders

“…These data prove the important role of the drug in reducing the level of active intracellular oxygen and calcium forms, which enhances its antioxidant properties [13,14,15]. It can also prevent overproduction of intracellular enzymes of superoxide dismutase, catalase, glutathione peroxidase [14,15]. Other neuroprotective effects of quetiapine include its capability of removing neurogenesis oppression in hippocampus caused by chronic stress [13,14,15].…”

“…Developing efficient strategies for correcting and preventing epileptic psychotic disorders remains an urgent issue in clinical practice since the current level of expertise in this pathology does not provide an unanimous understanding of the pathogenesis of these disorders. Quetiapine and its active metabolite norquetiapine act as antagonists to dopamine D2-receptors with moderate affinity [13,14], norquetiapine increases the concentration of the pre-frontal dopamine and serotonin [13,15], blocks the presynaptic receptors 5-HT7 [14,15], which explains its antipsychotic effect and the influence on the wide spectrum of affective and cognitive disorders. Improvement of cognitive functions in patients treated for schizophrenia and other psychoses can be explained by its low relationship and quick dissociation with dopamine D2receptors [13,14,15] [13,14,15] and was capable of protecting cell cultures from oxidative stress related to cytotoxicity induced by the β-amyloid [13,15].…”

“…Improvement of cognitive functions in patients treated for schizophrenia and other psychoses can be explained by its low relationship and quick dissociation with dopamine D2receptors [13,14,15] [13,14,15] and was capable of protecting cell cultures from oxidative stress related to cytotoxicity induced by the β-amyloid [13,15]. These data prove the important role of the drug in reducing the level of active intracellular oxygen and calcium forms, which enhances its antioxidant properties [13,14,15]. It can also prevent overproduction of intracellular enzymes of superoxide dismutase, catalase, glutathione peroxidase [14,15].…”

“…It can also prevent overproduction of intracellular enzymes of superoxide dismutase, catalase, glutathione peroxidase [14,15]. Other neuroprotective effects of quetiapine include its capability of removing neurogenesis oppression in hippocampus caused by chronic stress [13,14,15].…”