Characteristics of behavioral and psychological symptoms in the oldest patients with Alzheimer's disease

Furuta, Nobuo; Mimura, Masaru; Isono, Hiroshi; Sugai, Yuichi; Kamijima, Kunitoshi

doi:10.1111/j.1479-8301.2003.00034.x

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…These symptoms seem to have arisen from the sleep–wake pattern having some resemblance to delirium. Our results are partly compatible with those of Furuta et al 10 . They reported that behavioral abnormalities, such as excitement, delirium, reversed diurnal rhythm, and wandering were more frequently in very old patients with AD (>85 years old).…”

Section: Discussionsupporting

confidence: 93%

First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early‐onset Alzheimer's disease: Comparison with senile dementia of Alzheimer's type

Hori

Oda

Asaoka

et al. 2005

Psychiatry Clin Neurosci

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AbstractsWe evaluated dementia symptoms to clarify the character of dementia with Alzheimer's disease (AD) observed in the oldest old patients and that of dementia with early-onset AD. Subjects were consecutive AD inpatients admitted for the first time at age of 90 years and over because of behavioral symptoms (demented nonagenarian group: D90G; n = 18) and those with 24 consecutive inpatients with AD with early-onset (EOG). The Gottfries, Brane and Steen's scale and the Dementia Behavior Disturbance scale were used to evaluate the symptoms and troublesome behaviors. The scores of these scales in D90G and in EOG were compared with those of 26 sex distribution-, severity of dementia-, and disease duration-matched inpatients with AD with late-onset (LOG). Compared with LOG, wakefulness was more impaired and waking up at night was more frequent in D90G, while memory, orientation and inappropriate behaviors were more severe in EOG. These results suggest that the clinical features of dementia in EOG were quantitatively different from those of LOG. In contrast, the clinical feature of dementia of D90G were sleep-wake pattern disturbance and were qualitatively different from those of LOG. Key wordsAlzheimer's disease, behavioral and psychological symptoms of dementia, dementia, nonagenarian, oldest old.

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Section: Discussionsupporting

confidence: 93%

First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early‐onset Alzheimer's disease: Comparison with senile dementia of Alzheimer's type

Hori

Oda

Asaoka

et al. 2005

Psychiatry Clin Neurosci

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“…In the present study, we could contribute the aging effect on BPSD in AD. These differences are more prominent in the eldest of the aged patients with dementia (85 years and over or 90 years and over) and have been described in previous studies 13–16 …”

Section: Discussionsupporting

confidence: 76%

“…On the contrary, ‘psychosis’ was the first factor and explained 30.0% variance in the OG; however, it was the third factor and only explained 15.6% variance in the YG, although the severity of psychosis was not significantly different between the OG and YG. This meant that ‘psychosis’ was the most prominent symptom in the OG and more prominent than in the YG, and also meant that ‘psychosis’ was affected mainly by aging as has been reported previously 13,15,16 . In particular, Hamuro et al.…”

Section: Discussionmentioning

confidence: 84%

“…Prohovnik et al reported that in the eldest aged patients with Alzheimer's disease (AD) senile plaques and neurofibrillary tangles were not necessarily correlated with cholinergic deficit 7 . Many authors have compared clinical symptoms in the eldest of the aged with and without dementia (85 years and over, 90 years and over, and 100 years and over) with those in the younger aged 8–16 . In view of neuropsychiatric symptoms, the frequency and severity of behavioral and psychological symptoms of dementia (BPSD) were compared in the eldest of the aged with AD and the younger aged populations with AD.…”

Section: Introductionmentioning

confidence: 99%

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Effects of aging on behavioral symptoms in Alzheimer's disease

Konishi

Hori

Oda³

et al. 2009

Psychogeriatrics

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Aim: The aim of the present study was to evaluate the relationship between aging and the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD). Methods: Eligible subjects were consecutively referred AD patients with BPSD. According to patient age at the time of the test, the AD patient group (n = 79, whole AD group (WADG)) was divided into two groups: a relative older group (OG) in the whole AD group (WAD) (age at the time of test was 81 years or more, n = 40) and a relative younger group (YG) in the WAD (age at the time of test was below 81 years, n = 39). A comparison was made of the demographic data (sex difference, educational level and severity of dementia), cognitive functions and BPSD between the groups. BPSD was evaluated using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). The factor analysis of BPSD was conducted in the WADG as well as in the OG and YG. Results: Sex difference, educational level, severity of dementia and cognitive functions were not different; however, the total score of the BEHAVE-AD symptom domain in diurnal rhythm was significantly higher in the OG than in the YG (Student's t-test: P < 0.05). Factor analysis showed that psychosis was the first factor in the OG, but was the third factor in the YG and that the psychotic symptoms were caused by anxieties and phobias in the OG. Conclusion: From these results, we found that the effects of aging on the BPSD in AD were characterized by diurnal rhythm disturbance and psychosis.

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“…Thus, the prevalence rate of the disease is much higher for those persons aged 85 and older than it is for persons 65 and older (Centers for Disease Control and Prevention, 2017 ). Furthermore, it has been shown that persons with AD who are 85 years and older are more prone to exhibit the various behavioral symptoms that are often associated with the disease (Furuta, Mimura, Isono, Sugai, & Kamijima, 2004). Hence, the older the residents with AD, the more complicated the care can be.…”

Section: Characteristics Of Residents With Alzheimer's Diseasementioning

confidence: 99%

Fostering compassionate care for persons with Alzheimer's disease in nursing facilities.

Cotton¹

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and her behaviors worsened, we were finally given a diagnosis: Alzheimer's disease. I did not know at the time the extent to which her diagnosis would impact me, the rest of my childhood, and how I learned to understand caregiving. From the onset of the disease to the final days, I watched as my mother took care of my grandmother day in and day out. My mother would work all day at her job, come home and make dinner for me, and then spend the rest of her evening taking care of my grandmother. Alzheimer's is not a disease that simply impacts the person, but the persons' family, friends, and communities but most importantly, it is the caregiver that is often impacted the most. These early experiences taught me that the caregiving journey could be difficult and arduous, so I want to acknowledge the work of caregivers for persons with Alzheimer's disease. In particular, I would like to say thank you to three caregivers that have taught me so much along the way-Margie, Zelda, and Doris. I would also like to thank my committee. Each of you has given me the support that I needed along the way. Annatjie, you are the MENTOR. I am not sure I would have made it without your help and encouragement. You are so brilliant and amazing, and I am v so thankful for all the guidance you have given me through this journey. Joseph, words cannot express how grateful I am for you! Thank you for encouraging me each step of the way. You are amazing! Pamela, your friendship and guidance is so helpful to me. Laughing (and sometimes crying) in the kitchen while eating too much fruit has saved me on many a day when I doubted my abilities to finish this dissertation. Terry, thank you for always checking in with me about my progress. Your feedback was so valuable to me. Dr. Jicha, when I first started to do research focused on Alzheimer's disease, it was your name that I kept seeing in the literature over and over again. You have done so much to advance this field of research, and I am so thankful that you said yes to being part of my committee. To my Institute for Sustainable Health & Optimal Aging family, your support while I was working on my dissertation was invaluable. Thanks for always cheering me on along the way. To my family and my friends, thanks for being my support system! Finally, to Bryce for all of his love and support. I would not have started this journey without your unwavering support. Thanks for buying the ticket and taking the ride.

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Characteristics of behavioral and psychological symptoms in the oldest patients with Alzheimer's disease

Cited by 3 publications

References 23 publications

First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early‐onset Alzheimer's disease: Comparison with senile dementia of Alzheimer's type

First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early‐onset Alzheimer's disease: Comparison with senile dementia of Alzheimer's type

Effects of aging on behavioral symptoms in Alzheimer's disease

Fostering compassionate care for persons with Alzheimer's disease in nursing facilities.

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