Characteristics of Antlerogenic Stem Cells and Their Potential Application

Cegielski, Marek; Iżykowska, Ilona; Dziewiszek, Wojciech; Zatoński, Maciej; Bochnia, Marek; Kalisiak, Olga

doi:10.5772/8597

Cited by 6 publications

(12 citation statements)

References 77 publications

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“…Deer antlers are unique mammalian organs that undergo subsequent regrowth in response to seasonal changes throughout the animal's life and are thus a remarkably useful model of mammalian regeneration [ 20 , 21 ]. It has been suggested that the annual renewal of deer antlers involves a stem cell-based process [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration

Seo¹,

Kim

Kim³

et al. 2018

Stem Cells International

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Multipotent stem cells have the capacity to generate terminally differentiated cell types of each lineage; thus, they have great therapeutic potential for a wide variety of diseases. The most widely available stem cells are derived from human tissues, and their use for therapeutic application is limited by their high cost and low productivity. Herein, we report that conditioned media of mesenchymal stem cells (MSCs) isolated from deer antlers enhanced tissue regeneration through paracrine action via a combination of secreted growth factors and cytokines. Notably, DaMSC-conditioned media (DaMSC-CM) enhanced hair regeneration by activating the Wnt signaling pathway. In addition, DaMSC-CM had regenerative potential in damaged skin tissue through induction of skin regeneration-related genes. Remarkably, we identified round vesicles derived from DaMSC-CM, with an average diameter of ~120 nm that were associated with hair follicle formation, suggesting that secretory vesicles may act as paracrine mediators for modulation of local cellular responses. In addition, these secretory vesicles could regulate the expression of Wnt-3a, Wnt-10b, and lymphoid enhancer-binding factor-1 (LEF-1), which are related to tissue renewal. Thus, our findings demonstrate that the use of DaMSC-CM as a unique natural model for rapid and complete tissue regeneration has possible application for therapeutic development.

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Section: Introductionmentioning

confidence: 99%

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration

Seo¹,

Kim

Kim³

et al. 2018

Stem Cells International

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“…The source of ASC in this study was the product: “Revitacell: the preparation for regenerative mesotherapy”. Revitacell contains stem cells homogenate derived from the deer antler stem cell line MIC-1 (listed in CosIng Cosmetic Ingredient Database as: “Deer antler cell extract”) [ 25 ]. Full characteristic of MIC-1 cell line is described by Cegielski et al and Dąbrowska et al [ 25 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

“…Current study concerns effectiveness of extract of sonicated Antlerogenic Stem Cells (ASC) on chronic wound in human. Sonicated ASC from MIC-1 cell line [ 25 ] were tested on animal models for use in regenerative medicine. Preliminary studies on animals showed promising results [ 25 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Antlerogenic stem cells extract accelerate chronic wound healing: a preliminary study

Kmiecik¹,

Kulus

Popiel

et al. 2021

BMC Complement Med Ther

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Background Chronic wounds constitute a significant medical and social problem. Chronic wound treatment may be supported by various techniques, such as negative pressure therapy, phototherapy or stem cells therapy, yet most of those supporting therapies need more evidence to be used for standard wound care. Current study covers the use of sonicated Antlerogenic Stem Cells (ASC) extract on chronic wounds. Methods Study was performed on 20 dermatological patients with venous leg ulcers, divided into two groups – treated with and without ASC extract respectively. The area and circumference of the wounds during the follow-up visits were measured on the wound imprint. Dynamics of wound healing was determined and compared between control and study group; statistics includes changes in absolute values (wound area, circumference), as well as relative (percentage of wound decrease, circumference/area ratio) and their change in time. For the purpose of Ki-67 immunohistochemical staining, sections were sampled from the wound edge at distinct check-points during therapy. Results of both groups were compared with Student test or Mann-Whitney test, depending on results distribution. Results Besides Ki-67 expression, all tested wound healing parameters (including relative and absolute wound decrease and changes in circumference/area ratio) were statistically significant more favorable in experimental group. Conclusion ASC extract significantly supported standard chronic wound treatment. Due to small population of study the results should be considered preliminary, yet promising for further research.

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“…Cross-species injection of antlerogenic stem cells in rabbits has demonstrated increased number in hair follicles in the treated sites. Moreover, these xenogenous stem cells induced an insignificant immune response when compared with vehicle alone [50]. This breakthrough, despite the need for substantiation with more studies, has raised the possibility of using purified animal stem cells to promote hair growth in humans [10].…”

Section: Stem Cell-based Therapiesmentioning

confidence: 99%

Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride and Hair Transplantation

Sonthalia¹

2016

J Cosmo Trichol

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Patterned hair loss (PHL) is one of the most commonly encountered problems for dermatologists. PHL at an early age is often cosmetically unacceptable, tends to be persistent and inflicts a profound negative impact on one's quality of life. Androgenetic alopecia (AGA) affects both genders in a distinctive pattern of hair loss from the scalp (MPHL for male PHL and FPHL or female PHL). The etiopathogenesis of AGA is complex, so far the major factor emphasized to be involved has been the undesirable androgen metabolism at the hair follicle level. In this review article, we shall dwell upon the relatively newly understood pathophysiological factors behind the genesis of AGA apart from the hormonal factors like the Wnt/β-catenin pathway, follicular micro-inflammation, prostaglandin imbalance, loss of extracellular matrix and oxidative stress. Based on the sound understanding of these factors we will be elaborating upon therapies for treatment of AGA beyong minoxidil, finasteride and hair transplantation. Amongst the therapeutic options discussed include topical 5alpha reductase (AR) inhibitors like finasteride, oral 5AR inhibitor-dual receptor antagonist dutasteride, botanical 5AR inhibitors, oral anti-androgens and estrogens for FPHL like spiranolactone, drospirenone etc. Wnt/β-catenin activators like topical valproic acid, hair stem cell based therapies, prostaglandin based therapies, tetrapeptides, nutritional and anti-oxidants and many more.

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Characteristics of Antlerogenic Stem Cells and Their Potential Application

Cited by 6 publications

References 77 publications

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration

Antlerogenic stem cells extract accelerate chronic wound healing: a preliminary study

Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride and Hair Transplantation

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