Characteristics of anti-complementary biopolymer extracted from Coriolus versicolor

Jeong, Sang-Chul; Yang, Byung-Keun; Ra, K. S; Wilson, Michael; Cho, Yip; Gu, Young A; Song, Chulho

doi:10.1016/j.carbpol.2003.09.012

Cited by 22 publications

(19 citation statements)

References 20 publications

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“…(Note that the percentage values obtained were based on the amounts of total carbohydrate in EPS and IPS, respectively.) The proportion of glucose in IPS was also found to be very close to the reported value of 75% obtained from the fruit body extract [12] while Wang et al [25] reported that the EPS isolated contained only glucose.…”

Section: Composition Of Eps and Ipssupporting

confidence: 62%

“…Minor sugars reported by other workers included mannose, xylose, galactose, rhamnose, arabinose and fucose [12,15]. The variation in the results could be due to the different fungal strains which were reported to have slightly different monosaccharide composition [11,30].…”

Section: Composition Of Eps and Ipsmentioning

confidence: 74%

“…This fraction could be the protein-bound polysaccharide reported in the extracts of all strains of C. versicolor reported so far [11,30]. In relation to another recent study, three polysaccharide fractions were also obtained from the hot water extract of the fruit bodies of C. versicolor [12]. The molecular weights of these fractions were reported to be 1.2 · 10 6 , 1.5 · 10 5 and 1.5 · 10 3 Da obtained by gel permeation chromatography and the smallest fraction was also present as the highest concentration [12].…”

Section: Discussionmentioning

confidence: 97%

“…In relation to another recent study, three polysaccharide fractions were also obtained from the hot water extract of the fruit bodies of C. versicolor [12]. The molecular weights of these fractions were reported to be 1.2 · 10 6 , 1.5 · 10 5 and 1.5 · 10 3 Da obtained by gel permeation chromatography and the smallest fraction was also present as the highest concentration [12]. Some earlier studies appeared to have reported the presence of molecular species approximately 1.0 · 10 5 Da as was in the case of PSP obtained from the mycelia (i.e.…”

Section: Discussionmentioning

confidence: 99%

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Characterisation and bioactivity of protein-bound polysaccharides from submerged-culture fermentation of Coriolus versicolor Wr-74 and ATCC-20545 strains

Cui

Goh

Archer

et al. 2007

J Ind Microbiol Biotechnol

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The protein-bound polysaccharides of Coriolus versicolor (CPS) have been reported to stimulate overall immune functions against cancers and various infectious diseases by activating specific cell functions. A New Zealand isolate (Wr-74) and a patented strain (ATCC-20545) of C. versicolor were compared in this study. The fruit bodies of both strains were grown for visual verification. Both strains were grown in submerged-culture using an airlift fermentor with milk permeate as the base medium supplemented with glucose, yeast extract and salt. Metabolic profiles of both strains obtained over 7-day fermentation showed very similar trends in terms of biomass production (8.9-10.6 mg/ml), amounts of extracellular polysaccharide (EPS) from the culture medium (1150-1132 microg/ml), and intracellular polysaccharide (IPS) from the mycelium (80-100 microg/ml). Glucose was the dominant sugar in both EPS and IPS, and the polymers each consisted of three molecular weight fractions ranging from 2 x 10(6) to 3 x 10(3 )Da. Both the EPS and IPS were able to significantly induce cytokine production (interleukin 12 and gamma interferon) in murine splenocytes in vitro. Highest levels of interleukin 12 (291 pg/ml) and gamma interferon (6,159 pg/ml) were obtained from samples containing Wr-74 IPS (0.06 microg/ml) and ATCC 20545 IPS (0.1 microg/ml), respectively. The results indicated that lower levels of EPS and IPS generally resulted in higher immune responses than did higher polymer concentrations.

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Section: Composition Of Eps and Ipssupporting

confidence: 62%

Section: Composition Of Eps and Ipsmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Characterisation and bioactivity of protein-bound polysaccharides from submerged-culture fermentation of Coriolus versicolor Wr-74 and ATCC-20545 strains

Cui

Goh

Archer

et al. 2007

J Ind Microbiol Biotechnol

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“…Several bioactive polysaccharides have been isolated from botanical sources such as mushrooms, algae, lichens and higher plants [1][2][3][4] and many are relatively non-toxic with no significant side effects [1][2][3][4]. In recent decades, polysaccharides have attracted a great deal of attention and have been proven to be promising candidates as therapeutics in biomedical arena [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and immunomodulatory activities of polysaccharides from the roots of Sanguisorba officinalis

Zhang

Koyyalamudi

Jeong

et al. 2012

International Journal of Biological Macromolecules

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Integrated Development of Glycobiologics: From Discovery to Applications in the Design of Nanoparticular Drug Delivery Systems

Vauthier

Bertholon

Labarre

2006

Handbook of Pharmaceutical Biotechnology

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From the three major classes of biomolecules including proteins, nucleic acids and carbohydrates, the carbohydrates are, at the moment, the least exploited. The recent development of operating methods for the analysis of carbohydrates and for the synthesis of oligosaccharides supports the efforts made to investigate the roles of carbohydrates in biological phenomena. Research on carbohydrates is very active leading to discovery of new oligosaccharides and functions almost everyday as witnesses by the amount of papers published every month. The purpose of this chapter is to point out some of the functions of carbohydrates that have been identified and that may be interesting to integrate within the design of nanoparticulate drug carriers able to carry and target a drug to the diseased organs or cells. The complete control of the biodistribution of these systems which is mainly governed by their surface properties remains one of the major challenges to achieve. Among the different strategies proposed so far, it has been suggested to coat the nanoparticulate drug carriers with polysaccharides in order to mimic the surface of cells, bacteria or viruses and to confer the nanoparticles new surface properties including the biological activities of the carbohydrates. The coating of nanoparticulate drug carriers with certain types of carbohydrates may be interesting to give the nanoparticles specific recognition or signalling functions to improve their targeting specificity and efficiency. Other carbohydrates display very specific biological activities that may be interesting to combine with nanoparticulate drug carriers to create biologically active nanoparticulate systems. Many other examples will be discussed in this chapter and the benefit of the approach will be examined with the few examples of nanoparticulate drug carriers already developed on this basis.

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Characteristics of anti-complementary biopolymer extracted from Coriolus versicolor

Cited by 22 publications

References 20 publications

Characterisation and bioactivity of protein-bound polysaccharides from submerged-culture fermentation of Coriolus versicolor Wr-74 and ATCC-20545 strains

Characterisation and bioactivity of protein-bound polysaccharides from submerged-culture fermentation of Coriolus versicolor Wr-74 and ATCC-20545 strains

Antioxidant and immunomodulatory activities of polysaccharides from the roots of Sanguisorba officinalis

Integrated Development of Glycobiologics: From Discovery to Applications in the Design of Nanoparticular Drug Delivery Systems

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