Characteristics of aged ischemic stroke patients indicative of cardioembolism

Matsuzono, Kosuke; Mashiko, Takafumi; Ozawa, Tadashi; Miura, Kumiko; Suzuki, Masayuki; Furuya, Koji; Ozawa, Michiko; Anan, Yuhei; Shimazaki, Hideyuki; Koide, Reiji; Tanaka, Ryota; Kameda, Tomoaki; Fujimoto, Shigeru

doi:10.1007/s11239-020-02198-1

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…The participants included consecutive patients with ischemic stroke with an onset-to-door time of ≤ 7 days 13) , in whom CSVD markers could be evaluated on MRI during hospitalization. We defined BIS as an ischemic stroke that occurred while or shortly after bathing 6) .…”

Section: Patient Selection and Outcomesmentioning

confidence: 99%

Bathing-Related Ischemic Stroke: Association between Stroke Subtype and Cerebral Small Vessel Disease

Ishikawa,

Sato,

Okumura

et al. 2024

JAT

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Bathing-related ischemic stroke (BIS) is sometimes fatal. However, its mechanisms and risk factors remain unclear. We aimed to identify the incidence of stroke subtypes in BIS, and clarify the impact of cerebral small vessel disease (CSVD) on BIS.Methods: Consecutive patients with ischemic stroke between October 2012 and February 2022 were retrospectively screened. The inclusion criteria were: 1) onset-to-door time within 7 days; and 2) availability of the results of MRI evaluation of CSVD markers during hospitalization. BIS was defined as an ischemic stroke that occurred while or shortly after bathing. We investigated the incidence of the stroke subtype and the correlation between CSVD markers and BIS. Results: 1,753 ischemic stroke patients (1,241 [71%] male, median age 69 years) were included. 57 patients (3%) were included in the BIS group. A higher frequency of large artery atherosclerosis (LAA) (prevalence ratio [PR] 2.069, 95% confidence interval [CI] 1.089 to 3.931, p=0.026) and lower frequency of cardio-embolism (CES) (PR 0.362, 95% CI 0.132 to 0.991, p=0.048) in BIS cases were identified. Moreover, lower periventricular hyperintensity (PVH) Fazekas grade (PR 0.671, 95% CI 0.472 to 0.956, p=0.027) and fewer cerebral microbleeds (CMBs) in deep brain region (PR 0.810, 95%CI 0.657 to 0.999, p=0.049) were associated with BIS cases. Conclusions: The BIS group was more likely to develop LAA and less likely to develop CES. Lower PVH grade and fewer CMBs in deep brain region were associated with the development of BIS.

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Section: Patient Selection and Outcomesmentioning

confidence: 99%

Bathing-Related Ischemic Stroke: Association between Stroke Subtype and Cerebral Small Vessel Disease

Ishikawa,

Sato,

Okumura

et al. 2024

JAT

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show abstract

“…It affects approximately 15 million people worldwide, of which approximately 5 million die and 5 million are disabled for life ( Maida et al, 2020 ). In recent years, with the aging of the population, the risk of IS has greatly increased, resulting in great pain and economic burden to patients ( Matsuzono et al, 2021 ). Currently, studies in this area mainly focus on the regulation of pathological mechanisms, including apoptosis, inflammation, oxidative stress, and calcium overload ( Feske, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Experimental verification and comprehensive analysis of m7G methylation regulators in the subcluster classification of ischemic stroke

Tian

Yu²,

Lv³

et al. 2023

Front. Genet.

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Background: Ischemic stroke (IS) is a fatal cerebrovascular disease involving several pathological mechanisms. Modification of 7-methylguanosine (m7G) has multiple regulatory functions. However, the expression pattern and mechanism of m7G in IS remain unknown. Herein, we aimed to explore the effect of m7G modification on IS.Methods: We screened significantly different m7G-regulated genes in Gene Expression Omnibus datasets, GSE58294 and GSE22255. The random forest (RF) algorithm was selected to identify key m7G-regulated genes that were subsequently validated using the middle cerebral artery occlusion (MCAO) model and quantitative polymerase chain reaction (qPCR). A risk model was subsequently generated using key m7G-regulated genes. Then, “ConsensusClusterPlus” package was used to distinguish different m7G clusters of patients with IS. Simultaneously, between two m7G clusters, differentially expressed genes (DEGs) and immune infiltration differences were also explored. Finally, we investigated functional enrichment and the mRNA–miRNA–transcription factor network of DEGs.Results: RF and qPCR confirmed that EIF3D, CYFIP2, NCBP2, DCPS, and NUDT1 were key m7G-related genes in IS that could accurately predict clinical risk (area under the curve = 0.967). NCBP2 was the most significantly associated gene with immune infiltration. Based on the expression profiles of these key m7G-related genes, the IS group could be divided into two clusters. According to the single-sample gene set enrichment analysis algorithm, four types of immune cells (immature dendritic cells, macrophages, natural killer T cells, and TH1 cells) were significantly different in the two m7G clusters. The functional enrichment of 282 DEGs between the two clusters was mainly concentrated in the “regulation of apoptotic signaling pathway,” “cellular response to DNA damage stimulus,” “adaptive immune system,” and “pyroptosis.” The miR-214–LTF–FOXJ1 axis may be a key regulatory pathway for IS.Conclusion: Our findings suggest that EIF3D, CYFIP2, NCBP2, DCPS, and NUDT1 may serve as potential diagnostic biomarkers for IS and that the m7G clusters developed by these genes provide more evidence for the regulation of m7G in IS.

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Coexisting of aortic arch atheroma and atrial fibrillation for short-term recurrence and poor functional outcome in acute stroke

et al. 2021

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Characteristics of aged ischemic stroke patients indicative of cardioembolism

Cited by 6 publications

References 26 publications

Bathing-Related Ischemic Stroke: Association between Stroke Subtype and Cerebral Small Vessel Disease

Bathing-Related Ischemic Stroke: Association between Stroke Subtype and Cerebral Small Vessel Disease

Experimental verification and comprehensive analysis of m7G methylation regulators in the subcluster classification of ischemic stroke

Coexisting of aortic arch atheroma and atrial fibrillation for short-term recurrence and poor functional outcome in acute stroke

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