Characteristics of activated neurons in the suprachiasmatic nucleus when mice become hypothermic during fasting and cold exposure

Uchida, Yuzo; Tokizawa, Ken; Nagashima, Kei

doi:10.1016/j.neulet.2014.07.039

Cited by 12 publications

(7 citation statements)

References 27 publications

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“…As mammalian hibernators undergo multiple bouts of torpor and arousal but show no significant organ damage after hibernation 1 , 65 , they are excellent models for application of natural protective mechanisms in humans 66 , 67 . Fasted and cold-induced non-hibernating laboratory mice that mimic torpor-like conditions of hibernators are used to explore the molecular differences between induced and natural torpor 68 – 70 . To further understand the survival mechanism of mammalian torpor, we compared protein levels in mice at normal, fasted, and cold-treated states that partially mimic torpor in bats.…”

Section: Discussionmentioning

confidence: 99%

“…Twelve 11-week-old ICR male mice were obtained from Sino-British Sippr/BK Lab Animal Ltd (Shanghai, China), maintained in a 12-h dark-light cycle at 28 °C, and provided food and water ad libitum. Mice of this age were chosen as their torpor-like states had been successfully induced 68 – 70 . Mice were randomly divided into three groups (4 mice/group) at the seventh day after arrival: (1) ad libitum to food at 27 °C (control group), (2) ad libitum to food at 20 °C (cold-stimulated group), and (3) fasting at 27 °C (fasted group).…”

Section: Methodsmentioning

confidence: 99%

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Co-activation of Akt, Nrf2, and NF-κB signals under UPRER in torpid Myotis ricketti bats for survival

Huang

Liao²,

Han

et al. 2020

Commun Biol

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Bats hibernate to survive stressful conditions. Examination of whole cell and mitochondrial proteomes of the liver of Myotis ricketti revealed that torpid bats had endoplasmic reticulum unfolded protein response (UPRER), global reduction in glycolysis, enhancement of lipolysis, and selective amino acid metabolism. Compared to active bats, torpid bats had higher amounts of phosphorylated serine/threonine kinase (p-Akt) and UPRER markers such as PKR-like endoplasmic reticulum kinase (PERK) and activating transcription factor 4 (ATF4). Torpid bats also had lower amounts of the complex of Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-related factor 2 (Nrf2), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) (p65)/I-κBα. Cellular redistribution of 78 kDa glucose-regulated protein (GRP78) and reduced binding between PERK and GRP78 were also seen in torpid bats. Evidence of such was not observed in fasted, cold-treated, or normal mice. These data indicated that bats activate Akt, Nrf2, and NF-κB via the PERK-ATF4 regulatory axis against endoplasmic reticulum stresses during hibernation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Co-activation of Akt, Nrf2, and NF-κB signals under UPRER in torpid Myotis ricketti bats for survival

Huang

Liao²,

Han

et al. 2020

Commun Biol

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“…Other studies have shown that induced hypothermia leads to increased SCN activity 54,55 . There is a lack of evidence that the hypothermia itself modulates the synchronization.…”

Section: Discussionmentioning

confidence: 94%

Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats

Martin

Bonargent

Besnard

et al. 2020

Sci Rep

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Input from the light/dark (LD) cycle constitutes the primary synchronizing stimulus for the suprachiasmatic nucleus (SCN) circadian clock. However, the SCN can also be synchronized by nonphotic inputs. Here, we hypothesized that the vestibular system, which detects head motion and orientation relative to gravity, may provide sensory inputs to synchronize circadian rhythmicity. We investigated the resynchronization of core temperature (Tc) circadian rhythm to a six-hour phase advance of the LD cycle (LD + 6) using hypergravity (2 G) as a vestibular stimulation in control and bilateral vestibular loss (BVL) rats. Three conditions were tested: an LD + 6 exposure alone, a series of seven 2 G pulses without LD + 6, and a series of seven one-hour 2 G pulses (once a day) following LD + 6. First, following LD + 6, sham rats exposed to 2 G pulses resynchronized earlier than BVL rats (p = 0.01), and earlier than sham rats exposed to LD + 6 alone (p = 0.002). Each 2 G pulse caused an acute drop of Tc in sham rats (−2.8 ± 0.3 °C; p < 0.001), while BVL rats remained unaffected. This confirms that the vestibular system influences chronobiological regulation and supports the hypothesis that vestibular input, like physical activity, should be considered as a potent time cue for biological rhythm synchronization, acting in synergy with the visual system.

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“…One of the main thermosensitive regions is the POA, which is able to sense its own temperature as well as the one from peripheral tissues that have thermoreceptors as the skin, different organs and the spinal cord (Boulant, 1998;Zhao et al, 2017;Tan and Knight, 2018). Other groups have reported neuronal activation of the POA in mice which developed fever or hypothermia (Yoshida et al, 2005;Uchida et al, 2014). Furthermore, other hypothalamic regions, as the SCN and PVN, are capable of receiving and modulating thermal signals (Lu et al, 2001;Wanner et al, 2013;Guzmán-Ruiz et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Differential Thermoregulatory and Inflammatory Patterns in the Circadian Response to LPS-Induced Septic Shock

Fedele

Aiello

Caldart

et al. 2020

Front. Cell. Infect. Microbiol.

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Characteristics of activated neurons in the suprachiasmatic nucleus when mice become hypothermic during fasting and cold exposure

Cited by 12 publications

References 27 publications

Co-activation of Akt, Nrf2, and NF-κB signals under UPRER in torpid Myotis ricketti bats for survival

Co-activation of Akt, Nrf2, and NF-κB signals under UPRER in torpid Myotis ricketti bats for survival

Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats

Differential Thermoregulatory and Inflammatory Patterns in the Circadian Response to LPS-Induced Septic Shock

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