Characteristics, Biological Properties and Analytical Methods of <i>Trans</i>-Resveratrol: A Review

Riccio, Bruno Vincenzo Fiod; Fonseca-Santos, Bruno; Ferrari, Priscileila Colerato

doi:10.1080/10408347.2019.1637242

Cited by 47 publications

(26 citation statements)

References 204 publications

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“…They are mainly employed in pharmaceutical industries due to their anti-carcinogenic, anti-diabetic, anti-acne, antioxidant and anti-inflammatory activities. These properties make them a promising candidate for novel drugs [59]. The elicited callus culture of Vitis vinifera L. showed 8-10 times higher production of resveratrol levels in the 48 h after UV-C application than in the first 24 h. The highest resveratrol accumulation was recorded to be 62.23 µg/g of FW in a 12-day old culture [38].…”

Section: Uv-cmentioning

confidence: 99%

Comparative Effects of Different Light Sources on the Production of Key Secondary Metabolites in Plants In Vitro Cultures

Hashim

Ahmad

Drouet

et al. 2021

Plants

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Plant secondary metabolites are known to have a variety of biological activities beneficial to human health. They are becoming more popular as a result of their unique features and account for a major portion of the pharmacological industry. However, obtaining secondary metabolites directly from wild plants has substantial drawbacks, such as taking a long time, posing a risk of species extinction owing to over-exploitation, and producing a limited quantity. Thus, there is a paradigm shift towards the employment of plant tissue culture techniques for the production of key secondary metabolites in vitro. Elicitation appears to be a viable method for increasing phytochemical content and improving the quality of medicinal plants and fruits and vegetables. In vitro culture elicitation activates the plant’s defense response and increases the synthesis of secondary metabolites in larger proportions, which are helpful for therapeutic purposes. In this respect, light has emerged as a unique and efficient elicitor for enhancing the in vitro production of pharmacologically important secondary metabolites. Various types of light (UV, fluorescent, and LEDs) have been found as elicitors of secondary metabolites, which are described in this review.

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Section: Uv-cmentioning

confidence: 99%

Comparative Effects of Different Light Sources on the Production of Key Secondary Metabolites in Plants In Vitro Cultures

Hashim

Ahmad

Drouet

et al. 2021

Plants

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“…The biological activity of resveratrol is limited by isomerization into the cis -form and its poor solubility in aqueous solutions resulting in biological permeation [ 46 ]. Additionally, resveratrol is sensitive to alkaline pH, temperature fluctuation and exposure to light and oxygen [ 7 , 47 ].…”

Section: Bioavailability Of Resveratrolmentioning

confidence: 99%

“…Therefore, there have been numerous researches in attempt to increase resveratrol stability, solubility and permeation in biological membranes enabling its controlled release rate and targeted delivery in the last few years. Several drug delivery systems were investigated including cubosomes, cyclodextrins, dendrimers, liquid crystals, liposomes, micelles, microspheres, nano- and microemulsions, lipid nanocarriers and polymeric films [ 46 ]. Besides, there are resveratrol analogs with bioactivities similar to resveratrol with increased oral bioavailability such as pterostibene [ 48 ] and α-methylstilbene [ 49 ].…”

Section: Bioavailability Of Resveratrolmentioning

confidence: 99%

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

et al. 2021

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Resveratrol is a phytoalexin produced by many plants as a defense mechanism against stress-inducing conditions. The richest dietary sources of resveratrol are berries and grapes, their juices and wines. Good bioavailability of resveratrol is not reflected in its high biological activity in vivo because of resveratrol isomerization and its poor solubility in aqueous solutions. Proteins, cyclodextrins and nanomaterials have been explored as innovative delivery vehicles for resveratrol to overcome this limitation. Numerous in vitro and in vivo studies demonstrated beneficial effects of resveratrol in cardiovascular diseases (CVD). Main beneficial effects of resveratrol intake are cardioprotective, anti-hypertensive, vasodilatory, anti-diabetic, and improvement of lipid status. As resveratrol can alleviate the numerous factors associated with CVD, it has potential as a functional supplement to reduce COVID-19 illness severity in patients displaying poor prognosis due to cardio-vascular complications. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2 including regulation of the renin-angiotensin system and expression of angiotensin-converting enzyme 2, stimulation of immune system and downregulation of pro-inflammatory cytokine release. Therefore, several studies already have anticipated potential implementation of resveratrol in COVID-19 treatment. Regular intake of a resveratrol rich diet, or resveratrol-based complementary medicaments, may contribute to a healthier cardio-vascular system, prevention and control of CVD, including COVID-19 disease related complications of CVD.

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“…The biological activity of resveratrol is limited by isomerization into cis-form and its poor solubility in aqueous solutions resulting in biological permeation [46]. Additionally, resveratrol is sensitive to alkaline pH, temperature fluctuation and exposure to light and oxygen [7,47].…”

Section: Tissue Bioavailabilitymentioning

confidence: 99%

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to Covid-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

Gligorijević¹,

Stanić-Vučinić²,

Radomirović³

et al. 2021

Preprint

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Resveratrol is a phytoalexin produced by many plants as a defense mechanism against stress-inducing conditions. The richest dietary sources of resveratrol are berries and grapes, their juices and wines. Good bioavailability of resveratrol is not reflected in its high biological activity in vivo because of resveratrol isomerization and its poor solubility in aqueous solutions. Proteins, cyclodextrins and nanomaterials have been explored as innovative delivery vehicles for resveratrol to overcome this limitation. Numerous in vitro and in vivo studies demonstrated beneficial effects of resveratrol in cardiovascular diseases (CVD). Main beneficial effects of resveratrol intake are cardioprotective, anti-hypertensive, vasodilatory, anti-diabetic, and improvement of lipid status. As resveratrol can alleviate the numerous factors associated with CVD, it has potential as a functional supplement to reduce COVID-19 illness severity in patients displaying poor prognosis due to cardio-vascular complications. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2 including regulation of the renin-angiotensin system and expression of angiotensin-converting enzyme 2, stimulation of immune system and downregulation of pro-inflammatory cytokines release. Therefore, several studies already have anticipated potential implementation of resveratrol in COVID-19 treatment. Regular intake of resveratrol rich diet, or resveratrol-based complementary medicaments, may contribute to a healthier cardio-vascular system, prevention and control of CVD, including COVID-19 disease related complications of CVD.

show abstract

Characteristics, Biological Properties and Analytical Methods of Trans-Resveratrol: A Review

Cited by 47 publications

References 204 publications

Comparative Effects of Different Light Sources on the Production of Key Secondary Metabolites in Plants In Vitro Cultures

Comparative Effects of Different Light Sources on the Production of Key Secondary Metabolites in Plants In Vitro Cultures

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to Covid-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

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