Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: the Danish Nationwide ENFORCE Study

Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccination

“…The observation that average humoral responses to three-dose vaccination failed to protect against Omicron BA.1 infection is consistent with the extremely high rates of community transmission observed in many regions during the recent Omicron-driven pandemic waves. Given that third doses substantially boost humoral responses in individuals of all ages (29)(30)(31)(32), the risk of Omicron infection is likely to be higher among individuals who have received fewer than three doses (18,33) and is likely to increase with time following vaccination due to natural declines in antibody responses (26,(34)(35)(36)(37). Additional studies are needed to assess these factors.…”

Re: Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity

“…We read with great interest the article published by Ole Schmeltz Søgaard ( 1 ). The study allows us to comment on the limited information about the comorbidities that the authors assessed, especially on high-blood pressure (HBP) as one of the most important.…”

Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: author's response

“…We read the letter by Villacorta et al with interest ( 1 ). In the letter, the authors argue that it is important to assess high blood pressure as a risk factors for severe COVID-19 and that we did not include high blood pressure in the risk factor analyses in our article ( 2 ). While we agree that high blood pressure is a risk factor for severe COVID-19, our article is focused on a different topic - COVID-19 vaccination and risk factors for vaccine hypo-responsiveness.…”