Characteristics and Visual Outcome of Refractory Retinal Vasculitis Associated With Antineutrophil Cytoplasm Antibody–Associated Vasculitides

Lin, Miaoli; Anesi, Stephen D; Ma, Lina; Ahmed, Aseef; Small, Karen Wingartz; Foster, C. Stephen

doi:10.1016/j.ajo.2017.12.004

Cited by 16 publications

(9 citation statements)

References 36 publications

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“…40 Other biologics in addition to anti-TNF-α agents have been used to treat RV, including rituximab (anti-CD20), daclizumab (anti-CD25), and tocilizumab (IL-6R inhibitor). 3,20,41…”

Section: Immunomodulatory Therapymentioning

confidence: 99%

Antimicrobial Resistance Patterns Amid Community-Acquired Uropathogens in Outpatient Settings of a Tertiary Care Hospital in Thailand

Sangsuwan¹,

Jariyasoonthornkit²,

Jamulitrat³

2021

SMJ

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Retinal vasculitis is inflammation of retinal blood vessels typically resulting from infection or immune-mediated inflammatory processes. It may present as isolated ocular inflammation or as a part of severe or potentially fatal systemic disease. Ocular complications of retinal vasculitis include cystoid macular edema, neovascularization, tractional retinal detachment, and vitreous hemorrhage, which all greatly threaten vision. Multimodal imaging and thorough systemic investigations are the main tools for making a precise diagnosis, which aids in predicting disease prognosis and visual outcome as well as preserving a patient’s vision and possibly their life. This review aims to discuss the current understanding of retinal vasculitis as well as current diagnostic tools and treatments.

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“…40 Other biologics in addition to anti-TNF-α agents have been used to treat RV, including rituximab (anti-CD20), daclizumab (anti-CD25), and tocilizumab (IL-6R inhibitor). 3,20,41…”

Section: Immunomodulatory Therapymentioning

confidence: 99%

Antimicrobial Resistance Patterns Amid Community-Acquired Uropathogens in Outpatient Settings of a Tertiary Care Hospital in Thailand

Sangsuwan¹,

Jariyasoonthornkit²,

Jamulitrat³

2021

SMJ

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“…Rare reports of retinal and choroidal vasculitis have been presented, most of them appearing in GPA patients [15]. Similarly, retinal vessel occlusions have been reported in rare instances [16,17].…”

Section: Ocular and Orbital Clinical Presentationmentioning

confidence: 94%

Therapy of ocular complications in ANCA+ associated vasculitis

Sorin¹,

Răzvan-Marian²,

Daniela³

et al. 2021

rjo

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ANCA+ associated vasculitis (AAV) is a group of rare diseases with potentially vision-threatening complications. Ocular and orbital complications of these diseases are caused by vasculitis of the small vessels of the eye or by granulomatous mass formation. ANCA (anti-neutrophil cytoplasmic antibodies) represent a key component of pathophysiological pathways as well as a diagnostic marker. Various manifestations are reported in literature, scleritis and episcleritis being the most common, followed by pseudotumor orbitae. In vision-threatening orbital or ocular disease, aggressive systemic treatment with a combination of high-dose glucocorticoids and either cyclophosphamide or rituximab is needed. Certain cases require locoregional surgical management to preserve ocular integrity or vision. Ocular involvement of AAV remains a challenge in clinical practice, requiring multi-specialty cooperation in order to ensure the best possible visual outcome. Abbreviations: AAV = ANCA+ associated vasculitis, ANCA = anti-neutrophil cytoplasmic antibodies, GPA = granulomatosis with polyangiitis, EGPA = eosinophilic granulomatosis with polyangiitis, MPA = microscopic polyangiitis

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“…In another series of 140 patients with GPA evaluated at the Mayo Clinic over a 16-year period, 40 patients had ocular involvement, of which 4 (2.9%) had retinal vasculitis [39]. It has been reported that the most common cause of AAV associated retinal vasculitis is GPA rather than MPA and EGPA [40]. The most common presenting ocular symptoms were blurry vision and floaters.…”

Section: Retinovascular Manifestationsmentioning

confidence: 99%

“…The involved artery/arteriole may be attenuated with uneven thickness. AAV etiology should be considered when a combination of retinal and choroidal vasculitis with both artery and vein involvement is encountered in the clinic [40].…”

Section: Retinovascular Manifestationsmentioning

confidence: 99%

“…The diagnosis is usually confirmed by FFA, which shows delayed or incomplete filling in the distribution of the involved blood vessel or irregular leakage in areas of ischemia. Treatment includes intraocular injections of anti-vascular endothelial growth factor (VEGF) agents and panretinal laser photocoagulation, thereby reducing the release of VEGF from ischemic tissues [40].…”

Section: Retinovascular Manifestationsmentioning

confidence: 99%

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