Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006–2017

Han, Lei; Yao, Wenxi; Bian, Zuguang; Zhao, Yuan; Zhang, Hengdong; Ding, Boxiao; Si, Han; Li, Ping; Zhu, Baoli; Ni, Chunhui

doi:10.3390/ijerph16030437

Cited by 24 publications

(23 citation statements)

References 24 publications

(23 reference statements)

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“…A possible explanation for this finding might be that the prevention of pneumoconiosis through specific steps and increasing awareness of self-protection have greatly improved during these decades. For example, in order to strengthen surveillance for this and other types of occupational diseases, the Network Direct Report System of Occupational Diseases was constructed in 2006 in China 2 6. Surprisingly, a significantly negative association was found between AAPCs and SDIs when measures of the SDI were above 0.7 in silicosis, although the rate of incidence of silicosis was found to have had relatively fast growth in some high and high-middle SDI countries, including Singapore and New Zealand.…”

Section: Discussionmentioning

confidence: 99%

“…Since the discovery of pneumoconiosis in the 19th century, the prevention of occupational-based hazards and diseases has been mainly focused on control measures meant to help limit and reduce dust-caused, occupational-based hazards 6. The Joint International Labour Organization (ILO)/WHO Committee on Occupational Health established the ILO/WHO Global Programme for the Elimination of Silicosis following the recommendations of the 1995 12th Session, which called on world leaders to take appropriate steps for better prevention of silicosis 7.…”

Section: Introductionmentioning

confidence: 99%

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Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017

et al. 2020

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ObjectivesPneumoconiosis remains a major global occupational health hazard and illness. Accurate data on the incidence of pneumoconiosis are critical for health resource planning and development of health policy.MethodsWe collected data for the period between 1990 and 2017 on the annual incident cases and the age-standardised incidence rates (ASIR) of pneumoconiosis aetiology from the Global Burden of Disease Study 2017. We calculated the average annual percentage changes of ASIR by sex, region and aetiology in order to determine the trends of pneumoconiosis.ResultsGlobally, the number of pneumoconiosis cases increased by a measure of 66.0%, from 36 186 in 1990 to 60 055 in 2017. The overall ASIR decreased by an average of 0.6% per year in the same period. The number of pneumoconiosis cases increased across the five sociodemographic index regions, and there was a decrease in the ASIR from 1990 to 2017. The ASIR of silicosis, coal workers’ pneumoconiosis and other pneumoconiosis decreased. In contrast, measures of the ASIR of asbestosis displayed an increasing trend. Patterns of the incidence of pneumoconiosis caused by different aetiologies were found to have been heterogeneous for analyses across regions and among countries.ConclusionIncidence patterns of pneumoconiosis which were caused by different aetiologies varied considerably across regions and countries of the world. The patterns of incidence and temporal trends should facilitate the establishment of more effective and increasingly targeted methods for prevention of pneumoconiosis and reduce associated disease burden.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017

et al. 2020

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“…Silicosis, fibrosis of the lung due to inhalation of silica containing dust, remains a disease of the modern age [1]. Silicosis continues to be reported from traditional extractive and industrial operations in Brazil [2], China [3], India [4] and Zambia [5], among many others. Severe silicosis has appeared in new industrial settings, specifically the fabrication of engineered stone [6] and denim apparel sandblasting [7].…”

Section: Introductionmentioning

confidence: 99%

Predictors of silicosis and variation in prevalence across mines among employed gold miners in South Africa

et al. 2020

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Background: The stated intention to eliminate silicosis from the South African goldmining industry as well as current programmes to find and compensate ex-miners with silicosis require an understanding of variation in silicosis prevalence across the industry. We aimed to identify the predictors of radiological silicosis in a large sample of working miners across gold mines in South Africa. Methods: Routine surveillance chest radiographs were collected from 15 goldmine "clusters" in a baseline survey undertaken in preparation for a separate tuberculosis isoniazid prophylaxis trial. All images were read for silicosis by a health professional experienced in using the International Labour Organisation (ILO) classification. Profusion thresholds of > 1/0 and > 1/1 were used. Demographic and occupational information was obtained by questionnaire. Predictors of silicosis were examined in a multivariable logistic regression model, including age, gender, racial ascription, country of origin, years since starting mine employment, mine shaft, skill category, underground work status and tuberculosis. Results: The crude silicosis prevalence at ILO > 1/1 was 3.8% [95% confidence interval (CI) 3.5-4.1%]. The range across mine shafts was 0.8-6.9%. After adjustment for covariates, the interquartile range across shafts was reduced from 2.4 to 1.2%. Black miners [adjusted odds ratio (aOR) 2.8; 95% CI 1.1-7.2] and miners in full-time underground work (aOR 2.1; 95% CI 1.3-3.4) had substantially elevated odds of silicosis, while workers from Mozambique had lower odds (aOR 0.54; 95% CI 0.38-0.77). Silicosis odds rose sharply with both age and years since starting in the industry (p for linear trend < 0.005), with 95.5% of affected miners having > 15 years since first exposure and 2.2% < 10 years. Conclusions: In surveillance of silicosis in working gold miners time since first exposure remains a powerful predictor. Age appears to be an independent predictor, while the detection of radiological silicosis in short-service miners requires attention. Public risk reporting by mines should include factors bearing on silicosis prevalence, specifically dust concentrations, with independent verification. Studies of silicosis and tuberculosis in ex-miners are needed, supported by an accessible electronic database of the relevant medical and dust exposure records of all gold miners.

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“…Silica‐related pulmonary fibrosis (SPF), a diffuse non‐malignant parenchymal lung disease associated with occupational silica dust exposure, is a common worldwide occupational disease, the burden of which continues to grow in China . Although aetiological studies have associated occupational silica dust exposure to SPF, non‐occupational exposure to silica from the natural environment, second‐hand exposures as well as residential exposures also contribute partially to SPF .…”

Section: Introductionmentioning

confidence: 99%

miRNA sequencing reveals miRNA‐4508 from peripheral blood lymphocytes as potential diagnostic biomarker for silica‐related pulmonary fibrosis: A multistage study

Chu

Wang³

et al. 2019

Respirology

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Background and objective: This study aimed to identify miRNA as potential diagnostic biomarkers for silicarelated pulmonary fibrosis (SPF). Methods: We first performed a comprehensive miRNAseq screening in PBL of eight subjects exposed to silica dust (four individuals with SPF and four healthy controls). The promising miRNA were then evaluated in the first-stage validation using an independent GEO data set (GSE80555) of 6 subjects (3 individuals with SPF and 3 healthy controls), followed by a second-stage validation using 120 subjects exposed to silica dust (60 individuals with SPF and 60 healthy controls). Results: Thirty-five miRNA showed strong expression differences in miRNA-seq screening, while miRNA-4508 (P = 9.52 × 10 −3 ) was retained as a candidate after the first-stage validation (GSE80555), which was further confirmed in the second-stage validation with similar and strong effect (P = 9.93 × 10 −17 ). ROC analysis showed that miRNA-4508 could distinguish SPF cases from healthy controls with high AUC (0.886), with sensitivity of 81.7% and specificity of 86.7%. In addition, the miRNA-4508 upstream rs6576457 mutant A allele exhibited a strong association with susceptibility to SPF (OR = 1.64, 95% CI = 1.20-2.23, P = 0.002), while eQTL analysis revealed a potential association between different genotypes of rs6576457 and miRNA-4508 expression (P = 0.068) in 60 healthy subjects with silica dust exposure.Conclusion: miRNA-4508 may be a potential diagnostic marker for SPF, and rs6576457, a functional variant of miRNA-4508, may affect SPF susceptibility. The detailed mechanism of action of this miRNA remains to be elucidated. † Logistic regression analysis adjusted for age, gender, years of silica dust exposure and pack-years of smoking. miRNA, microRNA; OR, odds ratio; SNP, single nucleotide polymorphism.

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Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006–2017

Cited by 24 publications

References 24 publications

Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017

Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017

Predictors of silicosis and variation in prevalence across mines among employed gold miners in South Africa

miRNA sequencing reveals miRNA‐4508 from peripheral blood lymphocytes as potential diagnostic biomarker for silica‐related pulmonary fibrosis: A multistage study

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