Characteristics and Treatment Outcome of Culture-Positive Tuberculosis Patients Among Rural and Urban Residents in Jiangxi, China: A Retrospective Cross-sectional Study

Zhan, Jiahuan; Xiong, Guangchu; Luo, Dong; Peng, Yingquan; Chen, Xiaowen; Zeng, Lingbing; Chen, Kaisen

doi:10.1177/10105395231169083

Cited by 1 publication

(1 citation statement)

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“…The detection rate of MDR-TB in the main urban area was significantly higher than that in the county and township areas. Due to the particularity of medical policies (The registered permanent residence system in China has little impact on the treatment of confirmed cases), confirmed cases of TB in different residences, especially some complex, refractory and unsuccessful treatment cases were concentrated in the main urban area with relatively abundant medical resources, which is a major reason for the high MDR detection rate in the main urban areas [ 28 ]. In addition, high mental stress, poor medication compliance, irregular treatment, drug abuse, and direct spread of MDR strains [ 29 – 31 ] are all reasons for the high drug resistance of MTBC in the main urban area.…”

Section: Discussionmentioning

confidence: 99%

Regional differences of Mycobacterium tuberculosis complex infection and multidrug resistance epidemic in Luoyang

Wang,

Guo,

et al. 2024

BMC Infect Dis

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Background Tuberculosis (TB) remains a global public health event of great concern, however epidemic data on TB covering entire areas during the special period of the COVID-19 epidemic have rarely been reported. We compared the dissemination and multidrug-resistance patterns of Mycobacterium tuberculosis complex (MTBC) in the main urban area of Luoyang City, China (including six municipal jurisdictions) and nine county and township areas under its jurisdiction, aimed to establish the epidemiology of TB in this region and to provide reference for precision anti-TB in places with similar settings. Methods From 2020 to 2022, sputum samples were collected from 18,504 patients with confirmed, suspected and unexcluded TB in 10 designated TB medical institutions. Insertion sequence 6110 was amplified by PCR (rpoB gene detection if necessary) to confirm the presence of MTBC. PCR-positive specimens were analyzed by multicolor melting curve analysis to detect multidrug resistance. Results Among the 18,504 specimens, 2675 (14.5%) were MTBC positive. The positive rate was higher in the main urban area than in the county and township areas (29.8% vs. 10.9%, p < 0.001). Male, re-treated and smear-positive groups were high-burden carriers of MTBC. Individuals aged > 60 years were the largest group infected with MTBC in the main urban area, compared with individuals aged < 61 years in the county and township areas. The detection of multidrug-resistant TB (MDR-TB) was higher in the main urban area than in the county and township areas (13.9% vs. 7.8%, p < 0.001). In all areas, MDR-TB groups were dominated by males, patients with a history of TB treatment, and patients aged < 61 years. Stratified analysis of MDR-TB epidemiology showed that MDR4 (INH þ RIF þ EMB þ SM) was predominant in the main urban area, while MDR3 (INH þ RIF þ SM) was predominant in the county and township areas. MDR-TB detection rate and epidemiology differed among the county and township areas. Conclusions For local TB control, it is necessary to plan more appropriate and accurate prevention and control strategies according to the regional distribution of MTBC infection.

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Section: Discussionmentioning

confidence: 99%