Characteristics and Taxonomy of <i>Parvoviridae</i>

Chromatographic purification of recombinant adenoviral and adeno-associated viral vectors: methods and implications

“…[4][5][6] AAV is a small, nonenveloped, icosahedral virus 20-26 nm in diameter and with a linear single-stranded DNA genome of 4.7À6 kb. 7,8 Recombinant adeno-associated viral (rAAV) vectors as a class appear to be the most suitable for applications where persistent transgene expression is essential for achieving a therapeutic goal. 9,10 They have a broad host and cell lineage infectivity range for dividing and nondividing cells and are relatively nontoxic.…”

Parvovirus Gene Regulation

“…The autonomous viruses are more variable in their packaging. Minute virus of mice (MVM) and H1 package the minus (antisense) strand 99~ of the time, bovine parvovirus the minus strand 75 to 80~ of the time, and the human autonomous virus B19 packages both strands equally frequently (Bates et al, 1984;Cotmore & Tattersall, 1984;Siegl et al, 1985). LuIII virus packages only minus strands or both with equal frequency depending on the host cell (Majaniemi et al, 1981;Bates et al, 1984).…”

Парвовирусная Инфекция Гусей

“…Они высокоустойчивы во внешней среде и сохраняются в помещениях до 4 -6 месяцев и, обладая высокой стабильностью в лабораторных условиях, они представляют большую опасность, как контаминаты клеточных культур, препа-ратов вирусов и вакцин (P.Tattersall, D.Ward, 1978; R.E.F. Matthews, 1982; G. Siegl et al, 1985).…”