Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma

Giannini, Edoardo G.; Pieri, Giulia; Labanca, Sara; Torres, Maria Corina Plaz; Gasbarrini, Antonio; Biasini, Elisabetta; Campani, Claudia; Cazzagon, Nora; Foschi, Francesco Giuseppe; Mega, Andrea; Masotto, Alberto; Raimondo, Giovanni; Rapaccini, Gian Ludovico; Sacco, Rodolfo; Caturelli, Eugenio; Guarino, Maria; Tovoli, Francesco; Vidili, Gianpaolo; Brunetto, M.R.; Nardone, Gerardo; Svegliati‐Baroni, Gianluca; Magalotti, Donatella; Azzaroli, Francesco; Cabibbo, Giuseppe; Marco, Maria Di; Sangiovanni, A.; Trevisani, Franco; Biselli, Maurizio; Caraceni, Paolo; Gramenzi, Annagiulia; Benevento, Francesca; Granito, Alessandro; Muratori, L.; Piscaglia, Fabio; Bertellini, Federica; Farinati, Fabio; Palano, Giorgio; Pelizzaro, Filippo; Penzo, Barbara; Pinto, Eleonora; Allegrini, Gloria; Cammà, Calogero; Celsa, Ciro; Giuffrida, Paolo; Stornello, Caterina; Grova, Mauro; Giacchetto, C; Rancatore, Gabriele; Grassini, Maria Vittoria; Adotti, Valentina; Gitto, Stefano; Marra, Fabio; Rosi, Martina; Bevilacqua, Vittoria; Borghi, Alberto; Gardini, Andrea Casadei; Conti, Fabio; Napoli, Lucia; Domenicali, Marco; Migliano, Maria Teresa; Matthaeis, Nicoletta De; Ponziani, Francesca Romana; Olivani, Andrea; Missale, Gabriele; Cossiga, Valentina; Capasso, Mario; Morisco, Filomena; Marina, Ester; Facciorusso, Antonio; Lauria, Valentina; Ghittoni, Giorgia; Pelecca, Giorgio; Chegai, Fabrizio; Coratella, Fabio; Ortenzi, Mariano; Dell’Isola, Serena; Franzè, Maria Stella; Saitta, Carlo; Sauchella, Assunta; Dajti, Elton; Ravaioli, Federico; Oliveri, Filippo; Ricco, Gabriele; Romagnoli, V.; Inno, Alessandro; Marchetti, Fabiana; Coccoli, Pietro; Malerba, Antonio; Cappelli, Alberta; Golfieri, Rita; Mosconi, Cristina; Renzulli, Matteo

doi:10.1016/j.dld.2022.03.002

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…These studies are in favour of an important co-factor for malignancy represented by hepatitis viruses. Recently, the analysis of the Italian Liver Cancer Registry identified 80 cases of PBC with HCC after the year 2000 [87]. The median age was 71 years, and 50% were males; cirrhosis was present in 86.3% of cases.…”

Section: Risk Factors For Hcc In Pbc Patientsmentioning

confidence: 99%

Current Perspectives on the Molecular and Clinical Relationships between Primary Biliary Cholangitis and Hepatocellular Carcinoma

Floreani,

Gabbia,

De Martin

2024

IJMS

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Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by the immune-mediated destruction of small and medium intrahepatic bile ducts, with variable outcomes and progression. This review summarises the state of the art regarding the risk of neoplastic progression in PBC patients, with a particular focus on the molecular alterations present in PBC and in hepatocellular carcinoma (HCC), which is the most frequent liver cancer in these patients. Major risk factors are male gender, viral infections, e.g., HBV and HCV, non-response to UDCA, and high alcohol intake, as well as some metabolic-associated factors. Overall, HCC development is significantly more frequent in patients with advanced histological stages, being related to liver cirrhosis. It seems to be of fundamental importance to unravel eventual dysfunctional molecular pathways in PBC patients that may be used as biomarkers for HCC development. In the near future, this will possibly take advantage of artificial intelligence-designed algorithms.

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Section: Risk Factors For Hcc In Pbc Patientsmentioning

confidence: 99%

Current Perspectives on the Molecular and Clinical Relationships between Primary Biliary Cholangitis and Hepatocellular Carcinoma

Floreani,

Gabbia,

De Martin

2024

IJMS

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Hepatocellular carcinoma in patients with autoimmune hepatitis

Pasta,

Pieri,

Plaz Torres

et al. 2024

Journal of Hepatology

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High neutrophil-lymphocyte ratio indicates a worse response to ursodeoxycholic acid in primary biliary cholangitis: a retrospective cohort study

Zhu,

Zheng,

et al. 2023

BMC Gastroenterol

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Background Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by inflammation of the interlobular bile ducts. Ursodeoxycholic acid (UDCA) is the only FDA approved first-line therapy for PBC, but up to 40% of patients with PBC have an incomplete response to UDCA. Neutrophil-to-lymphocyte (NLR) has been used to predict prognosis in various liver diseases. There is limited evidence on the treatment response to UDCA in PBC patients. Our study aimed to evaluate the relationship between NRL and the response to UDCA treatment in PBC patients. Methods A total of 257 primary biliary cholangitis (PBC) patients treated with UDCA (13–15 mg/kg/d) were enrolled in this retrospective study. The response to treatment was evaluated based on alkaline phosphatase levels ≤1.67 times the upper limit of the normal value after 12 months of UDCA treatment. Multivariable logistic regression analysis was performed to investigate the association between NLR at baseline and the response to 12 months of UDCA treatment after adjusting for important confounding variables. The stability of the results was evaluated by unadjusted and adjusted models. Results The results of multiple regression analysis showed that NLR at baseline was positively associated with the nonresponse to UDCA treatment after adjustments for potential confounders (age, sex, BMI, hypertension, arterial plaque, thyroid disease, jaundice, albumin, globulin, total bile acid, ALP, GGT, LDLC, total cholesterol, hemoglobin, and APTT) (OR = 1.370, 95% CI 1.066–1.761). These results reveal that NLR is an independent risk factor for UDCA treatment nonresponse. Conclusions Our results suggest that PBC patients with a high NLR had a worse response to UDCA therapy.

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Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma

Cited by 4 publications

References 36 publications

Current Perspectives on the Molecular and Clinical Relationships between Primary Biliary Cholangitis and Hepatocellular Carcinoma

Current Perspectives on the Molecular and Clinical Relationships between Primary Biliary Cholangitis and Hepatocellular Carcinoma

Hepatocellular carcinoma in patients with autoimmune hepatitis

High neutrophil-lymphocyte ratio indicates a worse response to ursodeoxycholic acid in primary biliary cholangitis: a retrospective cohort study

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