Characteristics and Sensitization Risk Factors in Kidney Transplant Wait List Candidates: Panel Reactive Antibodies Status Is Crucial for Successful Kidney Allocation Systems in Turkey

Sahin, Gizem Kumru; Usta, Sura; Erdogmus, Siyar; Sendogan, Damla Ors; Kutlay, Sim; Ertürk, Şehsuvar; Keven, Kenan; Şengül, Şule

doi:10.6002/ect.2020.0304

Cited by 1 publication

(2 citation statements)

References 23 publications

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“…These anti‐donor HLA antibodies are produced when a potential transplant recipient is exposed to foreign antigens against HLA class I and II. This usually occurs in patients who have received a prior transplant, have previous pregnancies/miscarriages, have received multiple blood transfusions, and/or have had numerous infections, especially urinary tract infections Table 1 6 …”

Section: Definition Of Sensitizationmentioning

confidence: 99%

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Management of the sensitized pediatric renal transplant candidate

Puliyanda,

Jordan

2024

Pediatric Transplantation

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Kidney transplantation is the treatment of choice for patients with ESRD as it is associated with improved patient survival and better quality of life, especially in children. There are several barriers to a successful transplant including organ shortage, anatomic barriers, and immunologic barriers. One of the biggest immunologic barriers that precludes transplantation is sensitization, when patients have antibodies prior to transplantation, resulting in positive crossmatches with donor. 30%–40% of adult patients on the wait list are sensitized. There is a growing number of pediatric patients on the wait list who are sensitized. This poses a unique challenge to the pediatric transplant community. Therefore, attempts to perform desensitization to remove or suppress pathogenic HLA antibodies resulting in acceptable crossmatches, and ultimately a successful transplant, while reducing the risk of acute rejection, are much needed in these children. This review article aims to address the management of such patients both prior to transplantation, with strategies to overcome sensitization, and after transplantation with monitoring for allograft rejection and other complications.

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Section: Definition Of Sensitizationmentioning

confidence: 99%

“…This usually occurs in patients who have received a prior transplant, have previous pregnancies/miscarriages, have received multiple blood transfusions, and/or have had numerous infections, especially urinary tract infections Table 1. 6…”

Section: Definiti On Of S En S Itiz Ati Onmentioning

confidence: 99%

Management of the sensitized pediatric renal transplant candidate

Puliyanda,

Jordan

2024

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

Characteristics and Sensitization Risk Factors in Kidney Transplant Wait List Candidates: Panel Reactive Antibodies Status Is Crucial for Successful Kidney Allocation Systems in Turkey

Cited by 1 publication

References 23 publications

Management of the sensitized pediatric renal transplant candidate

Management of the sensitized pediatric renal transplant candidate

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