Characteristics and risk factors for extrapancreatic infection in patients with moderate or severe acute pancreatitis

Tien, Ni; Wen, Yi; Zhao, Bing; Ning, Ning; Chen, Erzhen; Mao, Enqiang; Zhou, Weijun

doi:10.1016/j.heliyon.2023.e13131

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Extra-pancreatic infections were defined as the presence of infection in at least one site outside the pancreas, confirmed or ruled out through multiple cultures from different sites. Common sites of infection include the respiratory tract, bloodstream, abdominal cavity, biliary tract, urinary tract, and the presence of Clostridium difficile in feces [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of early antibiotic treatment strategy on prognosis of acute pancreatitis

Wen,

Xu,

Zhang

et al. 2023

BMC Gastroenterol

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Background Antibiotic use in the early stages of acute pancreatitis is controversial. The purpose of this study was to investigate the effect of early antibiotic application on the prognosis of acute pancreatitis (AP). Materials and methods Clinical data of patients with primary AP admitted to our emergency ward within 72 hours of onset were retrospectively collected from January 2016 to December 2020. We classified patients with acute pancreatitis according to etiology and disease severity, and compared the differences in hospital stay, laparotomy rate, and in-hospital mortality among AP patients who received different antibiotic treatment strategies within 72 hours of onset. Results A total of 1134 cases were included, with 681 (60.1%) receiving early antibiotic treatment and 453 (39.9%) not receiving it. There were no significant differences in baseline values and outcomes between the two groups. In subgroup analysis, patients with biliary severe acute pancreatitis (SAP) who received early antibiotics had lower rates of laparotomy and invasive mechanical ventilation, as well as shorter hospital stays compared to those who did not receive antibiotics. In logistic regression analysis, the early administration of carbapenem antibiotics in biliary SAP patients was associated with a lower in-hospital mortality rate. Early antibiotic use in biliary moderate-severe acute pancreatitis (MSAP) reduced hospital stays and in-hospital mortality. Quinolone combined with metronidazole treatment in biliary mild acute pancreatitis (MAP) shortened hospital stays. Early antibiotic use does not benefit patients with non-biliary AP. Conclusion Strategies for antibiotic use in the early stages of AP need to be stratified according to cause and disease severity.

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Section: Methodsmentioning

confidence: 99%

Effect of early antibiotic treatment strategy on prognosis of acute pancreatitis

Wen,

Xu,

Zhang

et al. 2023

BMC Gastroenterol

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Amphipathic Liponecrosis Impairs Bacterial Clearance and Causes Infection During Sterile Inflammation

Kostenko,

Khatua,

Trivedi

et al. 2023

Gastroenterology

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Association of Cardiovascular Disease and Pancreatitis: What Came First, the Chicken or the Egg?

Chen,

Moin,

Virk

et al. 2023

JCM

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(1) Background: Recent studies suggest an association between pancreatitis and cardiovascular disease. This article aims to review the available evidence linking cardiovascular disease with acute and chronic pancreatitis. (2) Methods: A comprehensive search was conducted on the PubMed/MEDLINE database from inception to April 2022 using Medical Subject Heading and keywords related to pancreatitis and cardiovascular disease. The search was limited to English-language literature involving human subjects, and various study types, including observational studies, case–control studies, cohort studies, and clinical trials, were screened for eligibility. Following data extraction, the authors conducted a narrative synthesis of the studies. (3) Results: Longitudinal studies indicate that a history of acute pancreatitis is associated with an increased risk of acute atherosclerotic cardiovascular disease and acute coronary syndrome. Elevated triglyceride levels (>2000 mg/dL) have a temporal relationship with acute pancreatitis. Cross-sectional studies have shown that acute pancreatitis is associated with cardiac injury during the acute phase. Based on longitudinal studies, chronic pancreatitis is associated with an increased risk of cerebrovascular diseases. However, data regarding the relationship between chronic pancreatitis and myocardial infarction are conflicting. (4) Conclusions: Based on the available evidence, having a history of acute pancreatitis appears to increase the risk of acute atherosclerotic cardiovascular disease. However, there is insufficient evidence to conclude whether chronic pancreatitis is associated with cardiovascular disease, and no definitive studies have yielded conflicting results.

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Characteristics and risk factors for extrapancreatic infection in patients with moderate or severe acute pancreatitis

Cited by 3 publications

References 28 publications

Effect of early antibiotic treatment strategy on prognosis of acute pancreatitis

Effect of early antibiotic treatment strategy on prognosis of acute pancreatitis

Amphipathic Liponecrosis Impairs Bacterial Clearance and Causes Infection During Sterile Inflammation

Association of Cardiovascular Disease and Pancreatitis: What Came First, the Chicken or the Egg?

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