Characteristics and prognosis of primary thyroid non‐Hodgkin's lymphoma in Chinese patients

Abstract

Combined chemotherapy and radiotherapy may offer better outcome without the need for extensive resection, and surgery should be reserved to providing tissue for diagnosis. The patients with low-intermediate risk (IPI = 2) or stage IIE need be treated more aggressively.

T-cell Lymphoma of Thyroid Gland with Lennert Type of Morphology: A Case Report and Review of the Literature

“…Thyroid function tests and the clinical thyroid status of patients are found to be either euthyroid or hypothyroid goiter in all case reports [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Our patient was a case of sub-clinical goiter with a sudden onset of pressure symptoms.…”

“…B-cell lymphomas overwhelmingly outnumber their T-cell counterparts in thyroid gland, with only about twenty cases of TCL having been reported in the literature [2][3][4][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The first case of TCL of thyroid was reported in an English lady in 1977 [12].…”

“…Treatment options for B-cell NHL of thyroid are relatively well established while regimens for TCL of thyroid have not yet fully evolved and no survival statistics still exist for these cases, clearly owing to their rarity [2,3,14,16]. The patients have been treated by surgery, radiotherapy, chemotherapy, or various combinations thereof primarily based on clinical condition of the patient and the stage of disease [7,9].…”

“…Almost all primary thyroid lymphomas turn out to be a non-Hodgkin lymphoma (NHL) of B-cell origin of either marginal zone lymphoma of mucosa associated lymphoid tissue (MALT) or diffuse large B-cell lymphoma (DLBCL) type [2][3][4][5]. T-cell lymphoma (TCL) in the thyroid gland is distinctly rare with about 20 cases having been reported so far in the literature [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Age range of these cases was between 34 and 86 years with a male to female ratio of 1.15:1.…”

“…Most of the reported cases showed a low grade behavior on follow up unlike the aggressive behavior seen in conventional TCL [3,9]. Microscopic morphology, in these cases, is variable showing most commonly a small lymphocytic infiltrate invading the thyroid follicles, also forming lymphoepithelial bodies in some cases [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Immunohistochemistry (IHC) of tumors in these cases has often revealed a predominant T-cell population with positivity for CD2, CD3 & CD5, with one case also reporting loss for CD7 [6].…”