Characteristics and Predictors of Radiographic Local Failure in Patients With Spinal Metastases Treated With Palliative Conventional Radiation Therapy

Abstract

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Mature Local Control and Reirradiation Rates Comparing Spine Stereotactic Body Radiation Therapy With Conventional Palliative External Beam Radiation Therapy

“…For example, Chen et al evaluated 182 patients with spinal metastases after cEBRT treated with a median total dose of 30 Gy delivered in 10 fractions. 6 Local failure rates were 26.5%, 33.1%, and 36.5% at 6, 12, and 24 months, respectively. In another review of 603 patients treated with fractionation cEBRT regimens, ranging from 8 Gy in 1 fraction to 40 Gy in 20 fractions, local failure rates at 6, 12, and 24 months was 9%, 21%, and 31%, respectively.…”

Hypofractionated Radiation Therapy for Unresectable or Metastatic Sarcoma Lesions

“…For example, in a recently published study of nearly 300 patients treated with conventional palliative RT to the spine, only about 10 patients had sarcoma histology which precluded any histology-specific analysis. 42 In general, however, conventional palliative RT has resulted in local control rates around 50% to 70% among all malignancies, most of which are notably more responsive to RT than sarcomas. 43 , 44 , 45 The relative radio-resistance of sarcomas has been supported by preclinical and clinical data.…”

Spine Stereotactic Body Radiotherapy for Prostate Cancer Metastases and the Impact of Hormone Sensitivity Status on Local Control

“…The best data include a study in mixed histologies in 182 patients treated with cEBRT with a median OS of only 7.7 months, used a mix of computed tomography and MRI for radiographical follow-up, and reported 1-year and 2-year LC rates of 67% and 63%, respectively. 24 Another study in PCa-only spinal metastases with a median OS of 9 months in a variety of clinic scenarios (de novo and salvage cEBRT, postoperative, and HSPC and CRPC) reported a 1-year LC of 42%. 25 Overall, PCa metastases are well-controlled with SBRT, particularly when compared with cEBRT, although the relative impact of concurrent hormonal therapy is yet to be determined.…”